CAS: 620-20-2; 3-Chlorobenzylchloride

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CAS号873-63-2 3-氯苄醇 | CAS号108-41-8 间氯甲苯 | CAS号56-23-5 四氯化碳 | CAS号123150-61-8 hepta-1,2,4-tri... | CAS号7791-25-5 磺酰氯 | CAS号591-17-3 3-溴甲苯 | CAS号94-36-0 过氧化苯甲酰 | CAS号65108-07-8 (3-chlorophenyl... | CAS号191402-57-0 1-(1-chloro-2,2... | CAS号107285-30-3 3-[2-(3-CHLORO-... | CAS号106670-33-1 2-[(3-chloroben... | CAS号31251-41-9 8-氯-5,6-二氢-11H-... | CAS号31255-57-9 3-[2-(3-氯苯基)乙基]... | CAS号38092-89-6 甲基氯雷他定 | CAS号39191-07-6 3-氯-N-甲基苄胺 | CAS号51421-12-6 (3-氯苄基)-肼 | CAS号19962-20-0 1-chloro-3-(phe... | CAS号62706-92-7 2-[(3-chlorophe... | CAS号255861-49-5 3-[2-(3-chlorop...

3-氯甲苯置于n-羟基邻苯二甲酰亚胺,四溴化碳,三氯异氰尿酸,Copper(II) Acetate Monohydrate体系中,用 二氯甲烷 作为反应溶剂,化学反应 40.0H,以55%的收率获得产物间氯氯苄
参考文献:使用三氯异氰尿酸的轻度脂族和苯甲烃ch键式氯化反应
标题:使用三氯异氰尿酸的轻度脂族和苯甲烃ch键式氯化反应
摘要:我们介绍了使用n-羟基邻苯二甲酰亚胺(nhpi)作为自由基引发剂和可商购的三氯异氰尿酸(tcca)作为氯源,在25-30oc下仅1当量的底物对脂族和苄基烃的受控单氯化反应.催化量的cbr 4由于形成链状.cbr 3而大大减少了反应时间部首.苯甲酰ch氯化可为带有吸电子(50-85%)或弱供电子基团(31-73%)的芳烃提供中等至非常好的收率.环状脂族底物收率低(24-38%).产物可以克量级合成,然后通过蒸馏简单纯化.我们报告了3-甲基苯甲酸酯的第一次直接侧链氯化,得到3-(氯甲基)苯甲酸甲酯,这是合成血管扩张剂taprostene的重要组成部分.
DOI:10.1021/acs.Joc.6B02829

专利信息

专利号:US-5068360-A
优先权日:1990-01-25
标题 :Preparation of 2-(2'-thienyl)ethylamine derivatives and synthesis of thieno(3,2-C)pyridine derivatives therefrom
发明人：DEHOFF BRADLEY S
权利人:SYNTEX INC
摘要:An improved process for the synthesis of 2-(2'-thienyl)ethylamine from suitably functionalized derivatives of 2-(2'-thienyl)ethanol employing ammonia gas in the presence of a metal salt or liquid ammonia and alkyl ketone as a solvent. The 2-(2'-thienyl)ethylamine produced by this process is advantageously converted to ticlopidine.

专利号:US-5191090-A
优先权日:1990-01-25
标题:Preparation of 2-(2'-thienyl)ethylamine derivatives and synthesis of thieno[3,2-c]pyridine derivatives therefrom
发明人：DEHOFF BRADLEY S
权利人:SYNTEX INC
摘要:An improved process for the synthesis of 2-(2'-thienyl)ethylamine from suitably functionalized derivatives of 2-(2'-thienyl)ethanol employing ammonia gas in the presence of a metal salt or liquid ammonia and alkyl ketone as a solvent. The 2-(2'-thienyl)ethylamine produced by this process is advantageously converted to ticlopidine.

专利号:US-6608202-B1
优先权日:2001-08-21
标题:Process of synthesis of a tricyclic ketone intermediate
发明人：DORAN HENRY J; O'NEILL PAT M; WILLIAMS ROBERT P
权利人:SCHERING CORP
摘要:In one embodiment, the present invention describes the synthesis of a compound of Formula III, wherein X is halogen,and intermediates therefor from easily available starting materials by a simple route.

专利号:US-4997945-A
优先权日:1990-01-25
标 题:Carbamate salts of 2-(2'-thienyl)alkylamines
发明人：KHATRI HIRALAL N
权利人:SYNTEX INC
摘要:The carbamate salt of 2-(2'-thienyl)-alkylamines and particularly the ethylamine and its method of synthesis are disclosed. The carbamate salt of 2-(2'-thienyl)ethylamine is a stable, easily transportable crystalline material that can be converted to 2-(2'-thienyl)ethylamine, a useful intermediate in the synthesis of 5[(2-chlorophenyl)methyl]-4,5,6,7-tetrahydrothieno-[3,2-c]pyridine hydrochloride, also known as ticlopidine hydrochloride. The synthesis is carried out by reacting an amine of formula (I): (I) with CO2 in a hydrocarbon solvent to obtain the carbamate salt of formula II: II

专利号:US-7189864-B2
优先权日:1990-11-19
标 题:Method of preparing intermediates useful in synthesis of retroviral protease inhibitors
发明人：NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P
权利人:SEARLE & CO
摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.

专利号:US-6022996-A
优先权日:1990-11-19
标 题 :Method for making intermediates useful in synthesis of retroviral protease inhibitors
发明人：NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P
权利人:SEARLE & CO
摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.