CAS: 68282-49-5; 2-Butyl-1H-Imidazole-5-Carboxaldehyde

相似化合物

88634-80-4 83857-96-9 68283-19-2

上下游产品

CAS号68283-19-2 2-丁基-4-羟甲基咪唑 | CAS号83857-96-9 2-正丁基-5-氯-4-甲酰基咪唑 | CAS号7440-69-9 铋 | CAS号7440-44-0 活性炭 | CAS号108-10-1 甲基异丁基甲酮 | CAS号7440-06-4 铂 | CAS号50790-93-7 2-正丁基咪唑 | CAS号110-59-8 戊腈 | CAS号83857-96-9 2-正丁基-5-氯-4-甲酰基咪唑 | CAS号139742-78-2 5-bromo-2-butyl... | CAS号133040-03-6 4-[((2-丁基-5-甲酰基...

咪唑醛置于palladium 10% On Activated Carbon 氢气,三乙胺,盐酸,Sodium Carbonate体系中,用 甲醇,水 作为反应溶剂,20.0~30.0 °C,490.34 Kpa 条件下,反应 10.0H,以74%的收率获得产物2-丁基-1H-咪唑-4-甲醛
参考文献:Preparation Of 2-Substituted 4-Chloro-5-Formylimidazole And 5-Formylimidazole
标题:Preparation Of 2-Substituted 4-Chloro-5-Formylimidazole And 5-Formylimidazole
摘要:该发明涉及一种2-取代-5-甲酰基咪唑的制备过程,其中方便地避免了在技术中已知的2-取代-4-羟甲基咪唑的中间高压合成,并且获得了更高的产率.相反,建议通过一锅法合成涉及2-取代-4-氯-5-甲酰基咪唑来制备这种2-取代-5-甲酰基咪唑,从而利用额外的去卤化步骤.此外,发现在制备过程中使用三氟甲磺酸盐催化剂可以显著提高2-取代-4-氯-5-甲酰基咪唑本身的产率和纯度.

专利信息

专利号:EP-1871745-B1
优先权日:2005-04-15
标 题:Preparation of 2-substituted 4-chloro-5-formylimidazoles by vilsmeier reaction of the condensation product of glycine and an imido ester with a formamide in the presence of a triflate (trifluormethanesulphonate) catalyst
发明人：RAJNIKANT VYAS JANMEJAY; SATYA VARMA NIDADAVOLU VENKATA; PRAKASH SINGH ANAND
权利人:DISHMAN PHARMACEUTICALS AND CH
摘要:The invention relates to a preparation process for 2-substituted 5-formylimidazoles, wherein the intermediate high-pressurized synthesis of an 2-substituted 4-hydroxymethylimidazole as known in the art is conveniently avoided, and wherein much higher yields are obtained. Instead, it is proposed to prepare such 2-substituted 5-formylimidazoles via a one-pot synthesis involving 2-substituted 4-chloro-5-formylimidazole, thereby employing an additional hydrodehalogenation step. Moreover, it is found that the yield and purity of 2-substituted 4-chloro-5-formylimidazole itself can be significantly improved using a triflate catalyst in the preparation process.

专利号:CN-1684955-A
优先权日:2002-08-02
标 题:Dehydrophenylahistine and analogs thereof and synthesis of dehydrophenylahistine and analogs thereof

专利号:US-6339157-B1
优先权日:1998-08-06
标题:Synthesis of carboxamides from the catalyzed reaction of aldehydes and amines
发明人：BEI XIAOHONG; GURAM ANIL
权利人:SYMYX TECHNOLOGIES INC
摘要:Aldehydes are catalytically combined with amines to form carboxamides in one step using an oxidant and a metal-ligand complex or metal/ligand composition.

专利号:CN-101633655-B
优先权日:2002-08-02
标题 :Dehydrophenylahistine and its analogues and synthesis of dehydrophenylahistine and its analogues

专利号:CN-101633655-A
优先权日:2002-08-02
标 题 :Dehydrophenylahistine and its analogues and synthesis of dehydrophenylahistine and its analogues

专利号:CN-1934101-B
优先权日:2004-02-04
标题 :Dehydrophenylahistine and analogs thereof and synthesis of dehydrophenylahistine and analogs thereof