CAS: 7693-45-0; 4-Chlorophenyl Carbonochloridate

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CAS号106-48-9 对氯苯酚 | CAS号603-35-0 三苯基膦 | CAS号75-44-5 光气 | CAS号32315-10-9 三光气 | CAS号1193-00-6 对氯苯酚钠 | CAS号60-80-0 安替比林 | CAS号31558-52-8 Carbonic acid,4... | CAS号2005-08-5 苯甲酸4-氯苯酯 | CAS号16323-15-2 Carbamic acid, ... | CAS号13649-22-4 (4-chlorophenyl... | CAS号72305-96-5 (4-chlorophenyl... | CAS号74270-33-0 (4-chlorophenox... | CAS号83877-30-9 (4-chlorophenox... | CAS号22719-87-5 Carbonic acid,4...

对氯苯酚置于sodium Hydride体系中,用 乙醚,甲苯,苯 作为反应溶剂,化学反应 2.5H,反应生成 4-氯苯基氯甲酸酯
参考文献:Al Sabbagh,Mohamed Mowafak; Calmon,Michelle; Calmon,Jean-Pierre,Bulletin De La Societe Chimique De France,1983,Vol. 2,# 3-4,P. 73-77
标题:Al Sabbagh,Mohamed Mowafak; Calmon,Michelle; Calmon,Jean-Pierre,Bulletin De La Societe Chimique De France,1983,Vol. 2,# 3-4,P. 73-77

专利信息

专利号:US-8309706-B2
优先权日:1998-08-03
标 题 :Methods of synthesizing oligonucleotides using carbonate protecting groups and alpha-effect nucleophile deprotection
发明人：DELLINGER DOUGLAS J; CARUTHERS MARVIN H; BETLEY JASON R
权利人:DELLINGER DOUGLAS J; CARUTHERS MARVIN H; BETLEY JASON R; AGILENT TECHNOLOGIES INC
摘要:The invention provides methods for synthesizing oligonucleotides using nucleoside monomers having carbonate protected hydroxyl groups that are deprotected with α-effect nucleophiles. The α-effect nucleophile irreversibly cleave the carbonate protecting groups while simultaneously oxidizing the internucleotide phosphite triester linkage to a phosphodiester linkage. The procedure may be carried out in aqueous solution at neutral to mildly basic pH. The method eliminates the need for separate deprotection and oxidation steps, and, since the use of acid to remove protecting groups is unnecessary, acid-induced depurination is avoided. Fluorescent or other readily detectable carbonate protecting groups can be used, enabling monitoring of individual reaction steps during oligonucleotide synthesis. The invention is particularly useful in the highly parallel, microscale synthesis of oligonucleotides.

专利号:US-7417139-B2
优先权日:2003-08-30
标 题 :Method for polynucleotide synthesis
发明人：DELLINGER DOUGLAS J; SIERZCHALA AGNIESZKA B; CARUTHERS MARVIN H; DELLINGER GERALDINE F
权利人:AGILENT TECHNOLOGIES INC
摘要:Methods of forming an internucleotide bond are disclosed. Such methods find use in synthesis of polynucleotides. The method involves contacting a functionalized support with a precursor having an exocyclic amine triaryl methyl protecting group under conditions and for a time sufficient to result in internucleotide bond formation. The functionalized support includes a solid support, a triaryl methyl linker group, and a nucleoside moiety having a reactive site hydroxyl, the nucleoside moiety attached to the solid support via the triaryl methyl linker group. In particular embodiments, the precursor has the structure: n nwherein:n O and H represent oxygen and hydrogen, respectively R1 is hydrido, hydroxyl, protected hydroxyl, lower alkyl, modified lower alkyl, or alkoxy, one of R2 or R3 is a hydroxyl protecting group; and the other of R2 or R3 is a reactive group capable of reacting with the reactive site hydroxyl, Base is a heterocyclic base having an exocyclic amine group, and Tram is the exocyclic amine triaryl methyl protecting group.

专利号:US-10947231-B2
优先权日:2009-05-27
标题:Processes for the preparation of substituted tetrahydro beta-carbolines
发明人：HWANG PETER SEONGWOO; MOON YOUNG-CHOON; TAMIL ARASU; QI HONGYAN; ALMSTEAD NEIL
权利人:PTC THERAPEUTICS INC
摘要:Provided herein are improved processes for the synthesis of substituted tetrahydro beta-carboline derivatives. In particular, provided herein are improved processes useful for the preparation of (S)-4-chlorophenyl 6-chloro-1-(4-methoxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate. Formula (I):

专利号:WO-9700244-A1
优先权日:1995-06-19
标题 :Process for parallel synthesis of a non-peptide library
发明人：FRITZ JAMES E; KALDOR STEPHEN W
权利人:LILLY CO ELI; FRITZ JAMES E; KALDOR STEPHEN W
摘要:A process for the sequential preparation of a library of compounds having pharmaceutical usage. The process involves the sequential mixing of solution phase reagents, followed by scavenging of excess unreacted reagents with solid phase scavenging agents. The process is highly iterative and applicable for producing various ureas, thiureas, amides, carbonates and tertiary amines.

专利号:US-7385050-B2
优先权日:2003-08-30
标题 :Cleavable linker for polynucleotide synthesis
发明人：DELLINGER DOUGLAS J; DELLINGER GERALDINE F; CARUTHERS MARVIN H
权利人:AGILENT TECHNOLOGIES INC
摘要:Functionalized supports for polynucleotide synthesis are disclosed. The supports have linker moieties that are stable to conditions used in polynucleotide synthesis, but may be cleaved to release synthesized polynucleotides from the support. Methods of making the functionalized supports and methods of using are also disclosed. In particular embodiments of methods of making the functionalized supports, a solid support, on which an available reactive group is bound, is contacted with a reagent having the structure (I)n nPhos-Cgp-Trl-Cgp′Nucl   (I)n nwherein the groups are defined as follows:n Phos is a reactive phosphorus group capable of specifically reacting with an available reactive group on the support, Trl is a triaryl methyl linker group having three aryl groups, each bound to a central methyl carbon, at least one of said three aryl groups having one or more substituents, Cgp is a linking group linking the reactive phosphorus group and the triaryl methyl linker group, or is a bond linking the reactive phosphorus group and the triaryl methyl linker group, Nucl is a nucleoside moiety, wherein the nucleoside moiety is optionally part of a polynucleotide moiety, and Cgp′ is a linking group linking the nucleoside moiety and the triaryl methyl linker group, or is a bond linking the nucleoside moiety and the triaryl methyl linker group.n nIn typical embodiments, the solid support is contacted with the reagent having the structure (I) under conditions and for a time sufficient to result in a functionalized support having a nucleoside moiety bound to the solid support via a triaryl methyl linker group.

专利号:US-6222030-B1
优先权日:1998-08-03
标题:Solid phase synthesis of oligonucleotides using carbonate protecting groups and alpha-effect nucleophile deprotection