CAS: 926293-55-2; 6-Bromo-2-Methylnicotinaldehyde

该化合物是有机化合物,其特点是有环,这是一种由六人组成的芳香循环,含有一个氮原子;六点方位有溴原子,二点有甲基组,其独特的反应性和特性.三点有碳酸二甲酯功能组引入反应性甲酰胺杂交,使其在各种化学反应中有用,如核生殖添加和凝聚反应.该化合物一般是棕色液体或固体的黄色,视其纯度和形态而定.它溶于乙醇和二氯甲烷等有机溶剂,但水中的溶解性可能有限.由于其结构特征,6-Bromo-2-甲基丙烯酸-3-碳酸甲丙二丁胺可用作合成药物,农用化学剂和其他精美化学品的重要中间体.在处理这一化合物时,应采取安全防范措施,因为可能对健康造成危害,包括皮肤和眼睛产生刺激.

英文名称6-Bromo-2-Methylnicotinaldehyde
中文名称6-溴-2-甲基-吡啶-3-甲醛
IUPAC名称6-bromo-2-methylnicotinaldehyde
其它别名6-溴-2-甲基吡啶-3-甲醛; 6-Bromo-2-Methylpyridine-3-Carboxaldehyde
CAS编号926293-55-2
MFCD编号:MFCD13188654
EINECS号:840-289-8
分子式:C7H6BrNO
分子量:200.03
产品CID: 1965136
产品分类有机原料→分子砌块→芳杂环类化合物→吡啶类化合物

相似结构搜索
InChIKey: CUTAVXXGKKXAHQ-UHFFFAOYSA-N
InChI=1S/C7H6BrNO/c1-5-6(4-10)2-3-7(8)9-5/h2-4H,1H3…
计算化学: 氢键受体数2.0氢键供体数0.0可旋转键数1.0

相似化合物

1003711-39-4 1060805-97-1 1227562-32-4

MSDS等安全信息

GHS符号GHS07
危险类别特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2A
警示词Warning
危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

欧盟法规

C&L通报

上下游产品

CAS号39919-65-8 2,5-二溴-6-甲基吡啶 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号1060805-97-1 6-溴-2-甲基烟酸

合成工艺路线路线简述

39919-65-8 = 926293-55-2
反应条件:1.1 Reagents: Butyllithium Solvents: Diethyl Ether,Hexane; Rt -> -78 °C; -78 °C; 1 H,-78 °C1.2 1 H,-78 °C; -78 °C -> Rt; 1 H,Rt
标题:Substituted Imidazolidinones And Related Compounds As Chemokine Receptor Binding Compounds And Their Preparation,Pharmaceutical Compositions And Use In The Treatment Of Infection Of Target Cells By Human Immunodeficiency Virus
参考文献:World Intellectual Property Organization]

39919-65-8 = 926293-55-2
反应条件:1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran,Hexane; 20 Min,-78 °C1.2 30 Min,-78 °C
标题:Novel Triazole-Pyridine Substituted Pyrrolidinyl And Tetrahydro-2H-Pyranyl Acetic Acid Compounds As Lpa Antagonists
参考文献:World Intellectual Property Organization]

39919-65-8 = 926293-55-2
反应条件:1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran; 1 H,-78 °C1.2 Solvents: Dimethylformamide; -78 °C; 1 H,-78 °C; -78 °C -> 25 °C1.3 Reagents: Hydrochloric Acid Solvents: Water
标题:Preparation Of Pyridylpyridone Derivative Useful As Ret Kinase Inhibitor In The Treatment Of Ibs And Cancer
参考文献:World Intellectual Property Organization]

39919-65-8 = 926293-55-2
反应条件:1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran; -78 °C; 1 H,-78 °C1.2 1 H,-78 °C
标题:Preparation Of Hedgehog Antagonists Having Zinc Binding Moieties
参考文献:Australia]

39919-65-8 = 926293-55-2
反应条件:1.1 Reagents: Butyllithium Solvents: Diethyl Ether; 1 H,-78 °C1.2 1 H,-78 °C1.3 Reagents: Ammonium Chloride Solvents: Water; 1 H,15 °C
标题:Macrocyclic Azolopyridine Derivatives As Eed And Prc2 Modulators And Their Preparation
参考文献:World Intellectual Property Organization]

39919-65-8 = 926293-55-2
反应条件:1.1 Reagents: Butyllithium Solvents: Diethyl Ether,Hexane; -78 °C; 1 H,-78 °C1.2 1 H,Rt1.3 Reagents: Ammonium Chloride Solvents: Water
标题:Preparation Of N-(Pyridin-2-Yl)-4-(Benzimidazolyl)Pyrimidin-2-Amine Derivatives Useful As Cdk Kinase Inhibitors For The Treatment Of Proliferative Disease
参考文献:World Intellectual Property Organization]

39919-65-8 = 926293-55-2
反应条件:1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran; 1 H,-78 °C1.2 1 H,-78 °C; -78 °C -> Rt1.3 Reagents: Hydrochloric Acid Solvents: Water; Rt
标题:Preparation Of Quinoline Compounds As Ret Inhibitors
参考文献:World Intellectual Property Organization]

926293-55-2 = 926293-55-2 + 60032-57-7
反应条件:1.1 Reagents: Sodium Cyanoborohydride Solvents: Acetonitrile,Water; 16 H,Ph 5.8,30 °C1.2 Reagents: Ethanol1.3 Reagents: Molybdenum Hexacarbonyl,Cesium Hydroxide Catalysts: Palladate(1-),[2′-(Amino-Kn)[1,1′-Biphenyl]-2-Yl-Kc]Chloro[2′-(Dicyclohexylphos... Solvents: 1-Methoxy-2-Propanol,Water; 15 Min,80 °C
标题:Palladium-Catalyzed Hydroxycarbonylation Of (Hetero)Aryl Halides For Dna-Encoded Chemical Library Synthesis
作者:Li,Jian-Yuan; Miklossy,Gabriella; Modukuri,Ram K.; Bohren,Kurt M.; Yu,Zhifeng; Et Al
参考文献:Bioconjugate Chemistry 日期:2019 卷标:30(8) 页码:2209-2215

2,5-二溴-6-甲基吡啶,N,N-二甲基甲酰胺置于正丁基锂体系中,用四氢呋喃,正己烷作为反应溶剂,以50.2 %的收率获得产物6-溴-2-甲基烟醛
参考文献: Novel Triazole-Pyridine Substituted Pyrrolidinyl And Tetrahydro-2H-Pyranyl Acetic Acid Compounds As Lpa Antagonists[fr] Nouveaux Composés D'Acide Pyrrolidinyl Et Tétrahydro-2 H-Pyranyl Acétique à Substitution Par Triazole-Pyridine Utilisés En Tant Qu'Antagonistes De Lpa
标题: Novel Triazole-Pyridine Substituted Pyrrolidinyl And Tetrahydro-2H-Pyranyl Acetic Acid Compounds As Lpa Antagonists[fr] Nouveaux Composés D'Acide Pyrrolidinyl Et Tétrahydro-2 H-Pyranyl Acétique à Substitution Par Triazole-Pyridine Utilisés En Tant Qu'Antagonistes De Lpa
摘要:本申请涉及新型三唑-吡啶取代的吡咯烷基,四氢-2H-吡喃基,环己基和哌啶基乙酸化合物,其制备方法,包含它们的制药组合物,以及它们作为治疗与溶血磷脂酸受体(lpa)失调相关的疾病的药物的用途.