CAS: 110-06-5; 1,2-Di-Tert-Butyldisulfane

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CAS号75-66-1 叔丁基硫醇 | CAS号507-19-7 溴代叔丁烷 | CAS号1950-69-2 4-甲基苯磺酰溴 | CAS号507-20-0 氯代叔丁烷 | CAS号107-47-1 叔丁基硫醚 | CAS号1253941-93-3 (R)-1-phenylpro... | CAS号68048-41-9 tert-Butyl thio... | CAS号89861-46-1 [benzenecarbono... | CAS号106130-36-3 2-(tert-butyldi... | CAS号20129-23-1 (butyldisulfany... | CAS号7269-35-4 硫代苯甲酸 S-丁酯 | CAS号882-33-7 二苯二硫醚 | CAS号10544-50-0 1,2,3,4,5,6,7,8... | CAS号25592-09-0 3,5-dimethyl-1,... | CAS号558-17-8 2-碘-2-甲基丙烷 | CAS号17381-62-3 3,5-diphenyl-1,... | CAS号13845-20-0 3,5-diiodo-1,2,... | CAS号762-84-5 N-叔丁基乙酰胺 | CAS号5943-35-1 Di-tert-butyl t...

Di-Tert-Butyl Sulfite置于sodium Disulfide体系中,化学反应 1.0H,以86%的收率获得叔丁基二硫
参考文献:一种叔丁基二硫醚的制备方法
标题:一种叔丁基二硫醚的制备方法
摘要:本发明公开了一种叔丁基二硫醚的制备方法,所述制备方法包括以下工序:先以亚硫酸二叔丁酯,与二硫化二钠溶液反应,后经纯化得到产品.本发明采用亚硫酸二叔丁酯为原料,对比现有路线一般采用叔丁基硫醇或叔丁基氯为原料,具有创新优势,而且制备亚硫酸二叔丁酯的方法和原料都是价格便宜容易采购,且气味较小容易控制,整个反应条件温和,后处理操作简单,只需使用常规设备即可进行生产,解决了现有方法存在生产气味大环境难治理,生产成本高,不适用于工业化生产的问题.

专利信息

专利号:WO-2025044766-A1
优先权日:2023-08-31
标题:Use of silicon dioxide microspheres in synthesis of ultra-long oligonucleotide and method for synthesizing ultra-long oligonucleotide
发明人：SHI YONGYONG; ZHANG MANCANG; WANG LIBING; GAO PANPAN; FANG JUN
权利人:UNIV SHANGHAI JIAOTONG; SHANGHAI DYNEGENE TECH CO LTD
摘要:The present invention relates to the technical field of oligonucleotide synthesis. Disclosed are the use of silicon dioxide microspheres in the synthesis of an ultra-long oligonucleotide and a method for synthesizing an ultra-long oligonucleotide, wherein the silicon dioxide microspheres have a specific surface area of less than 1 m2/g, and preferably, the silicon dioxide microspheres have modification groups on the surface. The method for synthesizing an ultra-long oligonucleotide comprises: performing a coupling reaction on a nucleoside phosphoramidite synthesis unit using the silicon dioxide microspheres having modification groups on the surface as carriers under coupling reaction conditions. The prepared carriers can be used to prepare an ultra-long oligonucleotide.

专利号:US-7781488-B2
优先权日:2002-06-10
标 题:Post-cleavage sulfur deprotection for convergent protein synthesis by chemical ligation
发明人：BOTTI PAOLO; VILLAIN MATTEO; MANGANIELLO SONIA; GAERTNER HUBERT
权利人:AMYLIN PHARMACEUTICALS INC
摘要:The present invention provides a method and compositions for synthesizing an oligopeptide or polypeptide by convergent assembly of a plurality of pairs of oligopeptides in chemical ligation reactions. An important aspect of the present invention is an oligopeptide having a C-terminal disulfide-protected carboxythioester group that can be deprotected to spontaneously generate a free C-terminal thioester moiety. This allows a single precursor to participate in a succession of chemical ligation reactions, thereby making the convergent synthesis approach possible. The present invention is useful in methods for chemical synthesis of oligopeptides, polypeptides and proteins, and improves the efficiency of native chemical ligation reactions, particularly where four or more peptide fragments are used to assemble an oligopeptide, polypeptide or protein product.

专利号:US-12337036-B2
优先权日:2018-01-01
标题:Compounds and methods for trans-membrane delivery of molecules
发明人：ZIV ILAN; GRIMBERG HAGIT; DUBROVSKY JOSEPH
权利人:APOSENSE LTD
摘要:The Invention provides a novel delivery system for delivery of drugs across biological membranes. It provides novel chemical conjugates that comprise said delivery system, methods for synthesis of said compounds, and methods for utilization of said delivery system, among others, for delivery of genetic drugs into tissues and cells, in vitro, ex vivo, and in vivo, for the treatment of various medical disorders.

专利号:US-8012448-B2
优先权日:2009-07-13
标题 :Synthesis of metal chalcogenide nanocrystals using organodichalcogenide reagents
发明人：BRUTCHEY RICHARD L; FRANZMAN MATTHEW A; WEBBER DAVID H
权利人:UNIV SOUTHERN CALIFORNIA
摘要:A method of synthesizing metal chalcogenide nanocrystals involving the steps of combining an organodichalcogenide, a metal salt and a ligand compound to form a mixture; degassing the mixture to remove air and water from the mixture; heating the mixture at a temperature below the decomposition temperature of the organodichalcogenide for a period of time sufficient to form a metal chalcogenide nanocrystal.

专利号:US-6573387-B1
优先权日:1997-03-21
标 题 :Synthesis of α,β-substituted amino amides, esters, and acids
发明人：SHARPLESS K BARRY; RUBIN A ERIK
权利人:SCRIPPS RESEARCH INST
摘要:α,β-Unsaturated amides and esters are converted to α,β-substituted amino amides, esters, and acids. An α,βunsaturated amide or ester is first converted to an α,β-hydroxysulfonamide or hydroxycarbamate amide or ester using an osmium-catalyzed aminohydroxylation. The α,β-hydroxysulfonamide or hydroxycarbamate amides or esters is then cyclodehydrated to produce a α,β-N-sulfonyl- or the α,β-N-carbamoylaziridine amide or ester. The ring of aziridine intermediate is then nucleophilically opened in a regioselective manner with a variety of nucleophiles to give the $g(α,β-substituted amino- amides or esters. Preferred nucleophiles include sulfur, oxygen, carbon, and nitrogen nucleophiles.

专利号:US-9090629-B2
优先权日:2010-11-03
标题:Cytotoxic agents comprising new ansamitocin derivatives
发明人：CHARI RAVI V J; WIDDISON WAYNE C; WILHELM SHARON D
权利人:CHARI RAVI V J; WIDDISON WAYNE C; WILHELM SHARON D; IMMUNOGEN INC
摘要:New ansamitocin derivatives bearing a linking group are disclosed. Also disclosed are methods for the synthesis of these new ansamitocin derivatives and methods for their linkage to cell-binding agents. The ansamitocin derivative-cell-binding agent conjugates are useful as therapeutic agents, which are delivered specifically to target cells and are cytotoxic. These conjugates display vastly improved therapeutic efficacy in animal tumor models compared to the previously described agents.