CAS: 122-11-2; 4-Amino-N-(2,6-Dimethoxypyrimidin-4-yl)Benzenesulfonamide

该化合物是一种主要用于兽用药物治疗牲畜和家禽细菌感染和盘尾菌的磺酰胺抗生素,其特点是它通过干扰对细菌细胞代谢至关重要的叶酸合成而抑制细菌生长的能力,这种化合物通常通过口服施用,并因其相对长的半衰期而闻名,可以产生持久的治疗效果;硫二甲二苯酚在水中溶解,在各种条件下具有中等稳定性,尽管在有强酸或碱的情况下可降解;其化学结构包括一个对抗菌活动至关重要的磺胺组;虽然对一系列病原体有效,但由于对抗生素抗药性和食物产品中潜在残留物的关切,对硫二甲二苯胺的使用加以管制.因此,在动物宰杀之前坚持停用一段时间对于确保食品安全至关重要.

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CAS号37063-70-0 N-(2,6-dimethox... | CAS号100-05-0 4-nitrobenzened... | CAS号98-74-8 4-硝基苯磺酰氯 | CAS号555-25-9 磺胺二甲氧嘧啶D4 N4-乙酸 | CAS号77767-96-5 (2,6-dimethoxyp... | CAS号3289-50-7 4-氨基-2,6-二甲氧基嘧啶 | CAS号121-60-8 对乙酰氨基苯磺酰氯

合成工艺路线路线简述

  • 合成目标产物 Sulfadimethoxine 主要起始原料 4-(Acetylamino)-N-(2,6-Dimethoxy-4-Pyrimidinyl)Benzenesulfonamide
  • (文献来源)合成步骤主要原料 4-(Acetylamino)-N-(2,6-Dimethoxy-4-Pyrimidinyl)Benzenesulfonamide
4-氨基-2,6-二甲氧基嘧啶置于吡啶,Sodium Hydroxide体系中,化学反应生成磺胺二甲氧嗪
参考文献:Neue Reaktionen Am Sulfanilamid Und Neue N1-Substituierte Sulfanilamide
标题:Neue Reaktionen Am Sulfanilamid Und Neue N1-Substituierte Sulfanilamide
摘要:
Doi:10.1007/bf00903598

海关参考信息

专利信息


专利号:US-10768157-B2
优先权日:2015-10-20
标 题:Materials and methods for the detection of trace amounts of substances in biological and environmental samples
发明人:KABIR ABUZAR; FURTON KENNETH G
权利人:KABIR ABUZAR; FURTON KENNETH G; THE FLORIDA INTERNATIONAL UNIV BOARD OF TRUSTEES
摘要:The subject invention provides chemical compositions and synthesis strategies to create molecularly imprinted polymers (MIPs) via sol-gel processes. In a specific embodiment, the subject invention utilizes a(n) organic, inorganic, or metallic template analyte to create a hybrid organic-inorganic or inorganic three-dimensional network possessing cavities complementary to the shape, size, and functional orientation of the template molecule or ions. The subject invention further pertains to the use of the novel MIPs as selective solid phase extraction (SPE) sorbents for pre-concentration and clean-up of trace substances in biological and environmental samples. Synthesis of other molecularly imprinted polymers with environmental, pharmaceutical, chemical, clinical, toxicological, and national security implications can be conducted in accordance with the teachings of the subject invention.

专利号:US-10899773-B2
优先权日:2014-12-19
标 题 :Total synthesis of trioxacarcin DC-45-A2 and preparation of trioxacarcin analogs
发明人:NICOLAOU KYRIACOS C; CAI QUAN
权利人:UNIV RICE WILLIAM M
摘要:In one aspect, the present invention provides novel derivatives of trioxacarin analogs of the formula (I) wherein the variables are as defined herein. The application also provides compositions, methods of treatment, and methods of synthesis thereof.

专利号:US-2016185745-A1
优先权日:2013-08-07
标题:Analogs of vinaxanthone and xanthofulvin, methods of synthesis, and methods of treatments thereof
发明人:SIEGEL DIONICIO; CHIN MATTHEW; ELIASEN ANDERS; AXELROD ABRAM
权利人:UNIV TEXAS
摘要:The present invention relates generally to methods of synthesis of vinaxanthone and xanthofulvin, novel analogs, and methods of use thereof.

专利号:WO-2024130393-A1
优先权日:2022-12-21
标 题 :Nanoparticle and method of synthesis thereof
发明人:MOSKOVCHENKO SVITLANA
权利人:MOSKOVCHENKO SVITLANA
摘要:The present technology relates to nanoparticles, compositions comprising said nanoparticles, and methods of synthesis of said nanoparticles; wherein the nanoparticles comprise a metal nanoparticle core, a first coating of amphiphilic molecules, and a second coating of essential oil, essential oil primary constituent, or both, which combine the antimicrobial properties of metal nanoparticles, amphiphilic molecules, and essential oil or essential oil primary constituents.

专利号:US-9772338-B2
优先权日:2015-10-20
标题 :Materials and methods for the detection of trace amounts of substances in biological and environmental samples
发明人:KABIR ABUZAR; FURTON KENNETH G
权利人:KABIR ABUZAR; FURTON KENNETH G; UNIV FLORIDA INT
摘要:The subject invention provides chemical compositions and synthesis strategies to create molecularly imprinted polymers (MIPs) via sol-gel processes. In a specific embodiment, the subject invention utilizes a(n) organic, inorganic, or metallic template analyte to create a hybrid organic-inorganic or inorganic three-dimensional network possessing cavities complementary to the shape, size, and functional orientation of the template molecule or ions. The subject invention further pertains to the use of the novel MIPs as selective solid phase extraction (SPE) sorbents for pre-concentration and clean-up of trace substances in biological and environmental samples. Synthesis of other molecularly imprinted polymers with environmental, pharmaceutical, chemical, clinical, toxicological, and national security implications can be conducted in accordance with the teachings of the subject invention.

专利号:US-10443047-B2
优先权日:2014-05-01
标题 :Increasing cellular lipid production by increasing the activity of diacylglycerol acyltransferase and decreasing the activity of triacylglycerol lipase
发明人:TSAKRAKLIDES VASILIKI; BREVNOVA ELENA E
权利人:NOVOGY INC
摘要:Disclosed are methods and compositions for increasing the triacylglycerol content of a cell by up-regulating diacylglycerol acyltransferase and down-regulating triacylglycerol lipase. In some embodiments, a DGA1 protein is expressed and a native TGL3 gene is knocked out, thereby increasing the synthesis of triacylglycerol and decreasing its consumption, respectively.
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1: Apley MD. Clinical evidence for individual animal therapy for papillomatous digital dermatitis (hairy heel wart) and infectious bovine pododermatitis (foot rot). Vet Clin North Am Food Anim Pract. 2015 Mar;31(1):81-95, vi. doi: 10.1016/j.cvfa.2014.11.009. Review. doi: 10.1111/j.1365-3164.2012.01050.x. Epub 2012 Jun 27. Review. Review. Review. Review. Review. Review. Review. Polish. Review. German. Review. Review. German. Review. Review. Russian. Review. Review. Review. German. Review. Review. Review. Review.

合成参考文献


摘要:Chemotherapy, 14(37), 1969 []
摘要:Gigiena i Sanitariya. For English translation, see HYSAAV., 40(9)(115), 1975
摘要:S72 | NTUPHTW | Pharmaceutically Active Substances from National Taiwan University | DOI:10.5281/zenodo.3955664
摘要:
摘要:HANSCH,C ET AL. (1995)
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