CAS: 136590-83-5; 3,5-Dichloroisonicotinaldehyde

相似化合物

13958-93-5 153463-65-1 72990-37-5

上下游产品

3,5-dichloropyridine formic acid ethyl ester N,N-dimethyl-formamide Methyl formate 3,5-dichloropyridine-4-carbonitrile 3-chloro-5-cyclohexylsulfanyl-pyridine-4-carbaldehyde m-tolylsulfanyl-pyridine-4-carbaldehyde3-chloro-5-m-tolylsulfanyl-pyridine-4-carbaldehyde 3-(biphenyl-4-ylsulfanyl)-5-chloro-pyridine-4-carbaldehyde

3,5-二氯吡啶置于盐酸,水体系中,化学反应 2.17H,反应生成3,5-二氯吡啶-4-甲醛
参考文献:通过二氨甲基化直接合成卤代吡啶醛
标题:通过二氨甲基化直接合成卤代吡啶醛
摘要:具有两个或多个卤素原子的吡啶通过在 γ 或 β 位插入酸性最强的 C-H 键与甲硅烷基甲脒反应,得到相应的缩醛胺.它们水解产生醛.该反应通过甲硅烷基甲脒的强碱碳形式从吡啶中夺氢,然后在甲脒阳离子和吡啶阴离子之间形成cc键.
Doi:10.1002/chem.202301675

专利信息

专利号:US-12358903-B2
优先权日:2016-06-13
标题 :FXR (NR1H4) modulating compounds
发明人：BLOMGREN PETER A; CURRIE KEVIN S; FARAND JULIE; GEGE CHRISTIAN; KROPF JEFFREY E; XU JIANJUN
权利人:GILEAD SCIENCES INC
摘要:The present disclosure relates generally to compounds which bind to the NR1H4 receptor (FXR) and act as agonists of FXR. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds.

专利号:US-8952042-B2
优先权日:2009-08-19
标 题 :FXR (NR1H4) binding and activity modulating compounds
发明人：KREMOSER CLAUS; ABEL ULRICH; STEENECK CHRISTOPH; KINZEL OLAF
权利人:KREMOSER CLAUS; ABEL ULRICH; STEENECK CHRISTOPH; KINZEL OLAF; PHENEX PHARMACEUTICALS AG
摘要:The present invention relates to compounds of formula (1): n nwhere R, A, Q and Z are defined herein, or an enantiomer, diastereomer, tautomer, solvate, prodrug or pharmaceutical acceptable salt thereof. These compounds bind to the NR1H4 receptor (FXR) and act as agonists of the NR1H4 receptor (FXR). The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds, and to a process for the synthesis of said compounds.

专利号:US-8378104-B2
优先权日:2010-02-11
标 题 :7-aminofuropyridine derivatives
发明人：HORNBERGER KEITH R; BERGER DAN M; CHEN XIN; CREW ANDREW P; DONG HANQING; KLEINBERG ANDREW; LI AN-HU; MA LIFU; MULVIHILL MARK J; PANICKER BIJOY; SIU KAM W; STEINIG ARNO G; TARRANT JAMES G; WANG JING; WENG QINGHUA; SANGEM RAJARAM; GUPTA RAMESH C
权利人:OSI PHARMACEUTICALS LLC; HORNBERGER KEITH R; BERGER DAN M; CHEN XIN; CREW ANDREW P; DONG HANQING; KLEINBERG ANDREW; LI AN-HU; MA LIFU; MULVIHILL MARK J; PANICKER BIJOY; SIU KAM W; STEINIG ARNO G; TARRANT JAMES G; WANG JING; WENG QINGHUA; SANGEM RAJARAM; GUPTA RAMESH C
摘要:Compounds of Formula 1, as shown below and defined herein: n n n n n n n n n n n n pharmaceutically acceptable salts thereof, synthesis, intermediates, formulations, and methods of disease treatment therewith, including treatment of cancers, such as tumors driven at least in part by TAK1 or for which an appropriate TAK1 inhibitor is effective. This Abstract is not limiting of the invention.