CAS: 144809-28-9; 5-(4-(2-(5-Ethylpyridin-2-yl)Ethoxy)Benzylidene)Thiazolidine-2,4-Dione

该化合物是一种与抗糖尿病药物Pioglitazone有关的结构性杂质,该化合物在药物质量控制方面具有重要作用,是杂质特征分析和分析方法鉴定的参考标准,其定义明确的化学结构确保在药物研制和制造过程中可靠地识别和量化.这种杂质对于评估Pioglitazone配方的纯度和稳定性,协助遵守管制标准至关重要.高纯度合成和严格定性使其适合用于HPLC,LC-MS和其他色谱技术,支持在药物应用中精确的杂质监测.

英文名称5-(4-(2-(5-Ethylpyridin-2-yl)Ethoxy)Benzylidene)Thiazolidine-2,4-Dione
中文名称5-(4-(2-(5-乙基吡啶-2-基)乙氧基)亚苄基)噻唑烷-2,4-二酮
IUPAC名称(E)-5-(4-(2-(5-ethylpyridin-2-yl)ethoxy)benzylidene)thiazolidine-2,4-dione
其它别名(E)-5-(4-(2-(5-Ethylpyridin-2-yl)Ethoxy)Benzylidene)Thiazolidine-2,4-Dione; 5-[4-[2-(5-Ethyl-Puridin-2-Yl-Ethoxy)Benzyldene]Thiazolidine-2,4-Dione; 5-{{4-[2-(5-Ethyl-2-Pyridinyl)Ethoxy]Phenyl}Methylene}-2,4-Thiazolidione; 5-[[4-[2-(5-Ethyl-2-Pyridinyl)Ethoxy]; 5-(4-(2-(5-Ethyl-2-Pyridinydethoxy)Benzylidene)-2,4-Thiazol; 5-{4-[2-(5-Ethyl-2-Pyridinyl)Ethoxyl]Benzyldene}-2,4-Thiazolidinedione; 5-{4-[2-(5-Ethyl-Pyridin-2-yl)-Ethoxy]-; 5-[[4-[2-(5-Ethyl-2-Pyridinyl)Ethoxy]Phenyl]-Methylene]-2,4-Thiazolidinedione (Pioglitazone Impurity)
CAS编号144809-28-9
MFCD编号:MFCD06411145
EINECS号:604-444-1
分子式:C19H18N2O3S
分子量:354.43
产品CID: 683152
产品分类有机原料→分子砌块→芳杂环类化合物→吡啶类化合物

相似结构搜索
InChIKey: YNTUJOCADSTMCL-GZTJUZNOSA-N
InChI=1S/C19H18N2O3S/c1-2-13-3-6-15(20-12-13)9-10-24-16-7-4-14(5-8-16)11-17-18(22)21-19(23)25-17/h3-8,11-12H,2,9-10H2,1H3,(H,21,22,23)/b17-1…
计算化学: 氢键受体数5.0氢键供体数1.0可旋转键数6.0

相似化合物

6320-51-0 136401-69-9 1099596-27-6

物理性质

熔点156-159 °C
沸点156-159 °C
密度1.3±0.1 g/cm3
pKa:7.26±0.20(预测)
PSA:68.29
LogP:3.5894
折射率1.653
溶解性Acetonitrile (Slightly), Chloroform (Slightly), DMSO (Slightly)
外观形态白色至淡黄色固体
储存条件密封干燥,2-8°C

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302-H315-H319-H335
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
安全声明H303+H313+H333

上下游产品

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合成工艺路线路线简述

合成目标产物 5-{4-[2-(5-Ethyl-2-Pyridinyl)Ethoxyl]Benzyldene}-2,4-Thiazolidinedione 主要起始原料 Piperidine And 2,4-Thiazolidinedione And 4-[2-(5-Ethyl-2-Pyridinyl)Ethoxy]Benzyaldehyde
(文献来源)合成步骤主要原料 Piperidine 和 2,4-Thiazolidinedione 和 4-[2-(5-Ethyl-2-Pyridinyl)Ethoxy]Benzyaldehyde

2-(5-Ethyl-1-Oxypyridin-2-yl)Ethanol置于哌啶,氯化亚砜,溶剂黄146,三乙胺,Sodium Hydroxide,锌体系中,用甲醇,二氯甲烷,氯仿,水,N,N-二甲基甲酰胺,甲苯用作溶剂,化学反应 33.75H,反应生成5-[[4-[2-(5-乙基-2-吡啶基)-乙氧基]苯基]亚甲基]-2,4-噻唑烷二酮
参考文献:Novel Process To Prepare Pioglitazone Via Several Novel Intermediates
标题:Novel Process To Prepare Pioglitazone Via Several Novel Intermediates
摘要:一种制备噻唑烷二酮类药物的新工艺,首选为吡格列酮.还描述了参与其合成的新中间体,以及用于它们的制备和在医药中的应用的工艺.