CAS: 1675-66-7; N1,N9-Bis(2-Hydroxyethyl)Nonanediamide

该化合物是一种属于类胺的化学化合物,主要因其抗炎和止痛特性而得到承认,因此对药物应用感兴趣;该物质具有调节疼痛和炎症的能力,这是其与各种生物途径相互作用的结果;对氨酸盐进行的研究往往针对其在...

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ethanolamine acrylic acid azelaic acid

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    C.I.酸性橙108,丙烯酸 以78%的收率获得阿地米屈
    参考文献:Use Of N-Acyl Derivatives Of Aminoalcohols In The Manufacture Of A
    标题:Use Of N-Acyl Derivatives Of Aminoalcohols In The Manufacture Of A
    摘要:使用n-酰基氨基醇与一元和二元羧酸的衍生物来预防和治疗与兴奋性氨基酸引起的过度和持续兴奋相关的疾病.

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    专利信息


    专利号:US-9522192-B2
    优先权日:2012-12-13
    标 题:Polyethylene glycol derivatives of palmitoylethanolamide and analogous acylethanolamides
    发明人:CALIGNANO ANTONIO; D'AGOSTINO GIUSEPPE; LANERI SONIA; MELI ROSARIA; OSTACOLO CARMINE; RUSSO ROBERTO; SACCHI ANTONIA; TRONINO DIANA; DELLA VALLE FRANCESCO; DELLA VALLE MARIA FEDERICA; MARCOLONGO GABRIELE
    权利人:EPITECH GROUP SRL
    摘要:The synthesis of a series of Polyethylene glycol conjugates (esters and carbonates) of PEA and its analogous acylethanolamides, have higher water solubility and good hydrophilic/lipophilic balance, resulting in (i) improved accumulation in tissues (particularly skin and mucosae), (ii) prolonged release, and (iii) increased bioavailability. Improvement of PEA and analogous acylethanolamides levels in the tissues—particularly in the skin and mucosae—and their prolonged release is due to the improved bioavailability of related conjugates. Conjugates are able to extend the time frame in which PEA and analogous acylethanolamides exert their pharmacological effects.

    专利号:US-2014315720-A1
    优先权日:2012-10-24
    标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
    发明人:FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
    权利人:CELANESE ACETATE LLC
    摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.
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    主要参考文献


    1: Guida F, Rocco M, Luongo L, Persiani P, Vulpiani MC, Nusca SM, Maione S, Coluzzi F. Targeting Neuroinflammation in Osteoarthritis with Intra-Articular Adelmidrol. Biomolecules. 2022 Oct 11;12(10):1453. doi: 10.3390/biom12101453.
    2: Nageeb MM, Khatab MI, Abdel-Sameea AA, Teleb NA. Adelmidrol protects against non-alcoholic steatohepatitis in mice. Naunyn Schmiedebergs Arch Pharmacol. 2020 May;393(5):777-784. doi: 10.1007/s00210-019-01785-1. Epub 2019 Dec 18. 12(5):457. doi: 10.3390/metabo12050457.
    4: Fusco R, Cordaro M, Genovese T, Impellizzeri D, Siracusa R, Gugliandolo E, Peritore AF, D'Amico R, Crupi R, Cuzzocrea S, Di Paola R. Adelmidrol: A New Promising Antioxidant and Anti-Inflammatory Therapeutic Tool in Pulmonary Fibrosis. Antioxidants (Basel). 2020 Jul 9;9(7):601. doi: 10.3390/antiox9070601.

    合成参考文献


    参考文献:10.1007/978-981-99-1659-7_9
    摘要:Wyndaele JJ. Pathology-Pathophysiology: Ultrastructure of the Neurogenic Bladder. 2023. In: Handbook of Neurourology.
    参考文献:10.1007/978-3-031-67821-9_9
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