2,3,4,5-四氯-6-(三氯甲基)吡啶 反应生成4-氨基-3,5,6-三氯吡啶羧酸 参考文献:Van,De,Moesdijk,C. G. M.,Chem. And Ind.,1986,N 4,129-134 标题:Van,De,Moesdijk,C. G. M.,Chem. And Ind.,1986,N 4,129-134
专利号:WO-2024012791-A1 优先权日:2022-07-11 标题 :Electrochemical synthesis of pyrazolines and pyrazoles 发明人:BÄR ROBIN MAXIMILIAN; FORD MARK JAMES; KALDAS SHERIF JAMES; WALDVOGEL SIEGFRIED; HOFMANN SILJA; LINDEN MARTIN 权利人:BAYER AG 摘要:The present invention relates to an electrochemical process for the synthesis of pyrazolines and pyrazoles of formula (I). The process can be especially used for the synthesis of the herbicide safener mefenpyr-diethyl.
专利号:US-11046978-B2 优先权日:2016-03-16 标 题:Synthesis of isoprenoids and derivatives 发明人:GONZALEZ RAMON; CLOMBURG JAMES M; CHEONG SEOKJUNG 权利人:UNIV RICE WILLIAM M 摘要:This disclosure generally relates to the use of enzyme combinations or recombinant microbes comprising same to make isoprenoid precursors, isoprenoids and derivatives thereof including prenylated aromatic compounds. Novel metabolic pathways exploiting Claisen, aldol, and acyioin condensations are used instead of the natural mevalonate (MVA) pathway or 1-deoxy-d-xylulose 5-phosphate (DXP) pathways for generating isoprenoid precursors such as isopentenyl pyrophosphate (IPP), dimethylallyl pyrophosphate (DMAPP), and geranyl pyrophosphate (GPP). These pathways have the potential for better carbon and or energy efficiency than native pathways. Both decarboxylative and non-carboxylative condensations are utilized, enabling product synthesis from a number of different starting compounds. These condensation reactions serve as a platform for the synthesis of isoprenoid precursors when utilized in combination with a variety of metabolic pathways and enzymes for carbon rearrangement and the addition/removal of functional groups. Isoprenoid alcohols are key intermediary products for the production of isoprenoid precursors in these novel synthetic metabolic pathways.
专利号:US-7429658-B2 优先权日:2003-09-11 标题 :Synthesis of protected pyrrolobenzodiazepines 发明人:HOWARD PHILIP; MASTERSON LUKE 权利人:SPIROGEN LTD 摘要:A method of synthesis of a N-10 protected PBD compound of formula (I): n nvia an intermediate of formula (II) or formula (V):
专利号:US-4727146-A 优先权日:1980-07-03 标题 :Synthesis of chiral 1-benzyl-1,2,3,4-tetra-hydroisoquinolines by asymmetric reduction 发明人:RICE KENNER C 权利人:US HEALTH 摘要:In a short total synthesis of morphinan compounds, derivatives of 1-benzyl-1,2,3,4-tetrahydroisoquinoline are produced. Certain of these compounds, although highly aromatic and functionalized, can be optically resolved. The optically active enantiomers can serve as important intermediates for both natural and unnatural opioids. As a special function of this invention, certain of the derivatives, namely 4'-6' and 7'-9', may be hydrogenated to 1'-3' derivative by asymmetric reduction either of the catalytic or chemical type.
专利号:US-5248815-A 优先权日:1991-12-27 标 题 :Stereo-selective synthesis of 2-aryl-propionic acids of high optical purity by using chiral oxazolines 发明人:PARADIES HENRICH H 权利人:PARADIES HENRICH H 摘要:The present invention relates to a stereospecific chemical synthesis of optically pure enantiomers of 2-aryl-alkanoic acids, especially those of the biologically active (S)-aryl-propionic acids, in good chemical yields, useful for preparing large quantities thereof, and having a high optical purity.
专利号:US-11780952-B2 优先权日:2016-08-08 标题:Process for the synthesis of silylated polyurethanes and silylated polyurethane composition 发明人:LAFERTE OLIVIER 权利人:BOSTIK SA 摘要:The present invention provides a process for the synthesis of silylated polyurethanes, comprising three sequential steps, a step (i) of preparing NCO-terminated polyurethane, a step (ii) of partial grafting of the NCO functions with silane functions and a step (iii) of total grafting of the residual NCO functions with functions that react with the NCO functions by means of polyfunctional compounds. The present invention also provides a silylated polyurethane composition that can be obtained by means of the process according to the invention, an adhesive composition comprising said silylated polyurethane composition and a self-adhesive item obtained from the adhesive composition according to the invention.
1: Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides (Tenth Biennial Update), Board on the Health of Select Populations, Institute of Medicine, National Academies of Sciences, Engineering, and Medicine. Veterans and Agent Orange: Update 2014. Washington (DC): National Academies Press (US); 2016 Mar 29. doi: 10.1007/s00425-016-2512-8. Epub 2016 Apr 8. Review. Review. Review. Review. Review.
合成参考文献
摘要:World Review of Pest Control., 9(119), 1970 摘要:Neary DG et al; Environ Toxicol Chem 12: 585-92 (1993) 摘要:U.S. Environmental Protection Agency/Office of Prevention, Pesticides, and Toxic Substances. Reigart, J.R., Roberts, J.R. Recognition and Management of Pesticide Poisonings. 5th ed. 1999. EPA Document No. EPA 735-R-98-003, and available in electronic format at: 摘要:USEPA/Office of Water; Federal-State Toxicology and Risk Analysis Committee (FSTRAC). Summary of State and Federal Drinking Water Standards and Guidelines (11/93) To Present 摘要:USDA/ForestService; Pesticide Background Statements p.23 (1984) Agr Hdbk 633