CAS: 223251-25-0; 1-(2-(4-(Chloromethyl)Phenoxy)Ethyl)Azepane Hydrochloride

上下游产品

CAS号223251-16-9 (4-(2-(氮杂环庚烷-1-... | CAS号328933-65-9 4-(2-氮杂环庚烷-1-基乙... | CAS号623-05-2 对羟基苯甲醇 | CAS号26487-67-2 N-(2-氯乙基)六亚甲基亚胺盐酸盐 | CAS号2205-31-4 N-(2-氯乙基)六亚甲二胺 | CAS号198481-32-2 1-[[4-[2-(氮杂环庚烷... | CAS号198480-21-6 1-[4-(2-(氮杂环庚烷-...

对羟基苯甲醇置于氯化亚砜,Potassium Carbonate,Caesium Carbonate体系中,用 四氢呋喃,乙腈 用作溶剂,化学反应 30.0H,反应生成1-(2-(4-(氯甲基)苯氧基)乙基)氮杂烷盐酸盐
参考文献:通过三氮烯定向的c-h环合成一般有效地合成吲哚
标题:通过三氮烯定向的c-h环合成一般有效地合成吲哚
摘要:用标题方法制备未保护的吲哚,该方法广泛用于炔烃.对芳基-烷基和烷基-烷基二取代的乙炔具有出色的区域选择性.该反应具有不寻常的1,2铑迁移和环收缩触发的nn键断裂.它可以将反应产物快速转化为几种功能分子.
Doi:10.1002/anie.201301742

专利信息

专利号:US-10844047-B2
优先权日:2018-06-21
标题:Process for the preparation of bazedoxifene
发明人：FERRARI MASSIMO; ZANI DANIELE DE; VEZZOSI STEFANO; BELOTTI PAOLO
权利人:ERREGIERRE SPA
摘要:The invention relates to a process for preparation of the compound 3-methyl-5-benzyloxy-2-(4-benzyloxyphenyl)-1H-indole 5, an intermediate for the synthesis of bazedoxifene and bazedoxifene acetate.

专利号:EP-1025077-B1
优先权日:1997-10-15
标题 :Novel aryloxy-alkyl-dialkylamines
发明人：RAVEENDRANATH PANOLIL; ZELDIS JOSEPH; VID GALINA; POTOSKI JOHN RICHARD; REN JIANXIN
权利人:WYETH CORP
摘要:The present invention provides compounds useful in the synthesis of biologically active compounds, and processes for their production, the compounds having formula (I) wherein: R?1 and R2¿ are, independently, selected from H; C¿1?-C12 alkyl or C1-C6 perfluorinated alkyl; X represents a leaving group; A is O or S; m is an integer from 1 to 3, preferably 2; R?3, R4, R5, and R6¿ are independently selected from H, halogen, -NO¿2?, alkyl, alkoxy, C1-C6 perfluorinated alkyl, OH or the C1-C4 esters or alkyl ethers thereof, -CN, -O-R?1¿, -O-Ar, -S-R1, -S-Ar, -SO-R1, -SO-Ar, -SO¿2?-R?1, -SO¿2-Ar, -CO-R1, -CO-Ar, -CO¿2-R?1, or -CO¿2?-Ar; and Y is selected from a) the moiety (i) wherein R7 and R8 are independently selected from the group of H, C1-C6 alkyl, or phenyl; or b) an optionally substituted five-, six- or seven-membered saturated, unsaturated or partially unsaturated heterocycle or bicyclic heterocycle containing up to two heteroatoms selected from the group consisting of -O-, -NH-, -N(C1C4 alkyl)-, -N=, and -S(O)n-.

专利号:US-6268504-B1
优先权日:1997-10-15
标题 :Aryloxy-alkyl-dialkylamines
发明人：RAVEENDRANATH PANOLIL; ZELDIS JOSEPH; VID GALINA; POTOSKI JOHN R; REN JIANXIN; IERA SILVIO
权利人:AMERICAN HOME PROD
摘要:The present invention provides compounds useful in the synthesis of biologically active compounds, and processes for their production, the compounds having the formula:wherein: R1 and R2 are, independently, selected from H; C1-C12 alkyl or C1-C6 perfluorinated alkyl; X represents a leaving group; A is O or S; m is an integer from 1 to 3, preferably 2; R3, R4, R5, and R6 are independently selected from H, halogen, -NO2, alkyl, alkoxy, C1-C6 perfluorinated alkyl, OH or the C1-C4 esters or alkyl ethers thereof, -CN, -O-R1, -O-Ar, -S-R1, -S-Ar, -SO-R1, -SO-Ar, -SO2-R1, -SO2-Ar, -CO-R1, -CO-Ar, -CO2-R1, or -CO2-Ar; and Y is selected from a) the moiety:wherein R7 and R8 are independently selected from the group of H, C1-C6 alkyl, or phenyl; or b) an optionally substituted five-, six- or seven-membered saturated, unsaturated or partially unsaturated heterocycle or bicyclic heterocycle containing up to two heteroatoms selected from the group consisting of -O-, -NH-, -N(C1C4 alkyl)-, -N=, and -S(O)n-.