CAS: 24103-75-1; 4-Methoxy-2-Methylpyridine

相似化合物

1211533-95-7 18615-86-6 36057-44-0

上下游产品

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2-甲基吡啶氧化物置于硫酸,Potassium Tert-Butylate,硝酸,铁粉,溶剂黄146体系中,化学反应 20.0H,反应生成4-甲氧基-2-甲基吡啶
参考文献: Antibiotic Compounds[fr] Composés Antibiotiques
标题: Antibiotic Compounds[fr] Composés Antibiotiques
摘要:本发明涉及公式(i)的抗生素化合物,含有这些化合物的组合物,以及使用这些化合物治疗细菌性疾病和感染的方法.这些化合物在治疗革兰氏阳性和/或革兰氏阴性细菌引起的感染和疾病方面具有应用,特别是在治疗由淋病奈瑟菌引起的感染和疾病方面.

专利信息

专利号:US-5591867-A
优先权日:1992-12-04
标 题 :Synthesis of kainic acid
发明人：MONN JAMES A
权利人:LILLY CO ELI
摘要:This invention provides a process for preparing kainic acid and provides intermediates in the synthesis thereof.

专利号:US-4526974-A
优先权日:1982-03-25
标 题 :Synthesis of 2-pyridylalkylamines
发明人：ADGER BRIAN M; MASTROCOLA ANTONIETTA R
权利人:SMITH KLINE FRENCH LAB
摘要:The invention provides a process for preparing 2-pyridylalkylamines by reacting an alkali metal derivative of a 2-methylpyridine with a haloalkylamine. The compounds are useful as intermediates in the preparation of compounds having histamine H 1 - and H 2 -antagonist activity.

专利号:WO-2023091726-A1
优先权日:2021-11-18
标题:Inhibitors of cyclin‑dependent kinase 12 (cdk12)
发明人：BENOIT GUILLAUME; CARULLI JOHN; CHEN FEI; CHUAQUI CLAUDIO; CIBLAT STEPHANE; COOPER ELLIOT; DAGENAIS ROBIN; HU SHANHU; KABRO ANZHELIKA; LAPLACA DEREK; MARINEAU JASON; MOEBIUS DAVID; MOON DIANE; SOLODININ ANDREI; WHITMORE KENNETH
权利人:SYROS PHARMACEUTICALS INC
摘要:The present invention provides chemical compounds that inhibit one or more families of kinases (e.g., serine/threonine kinases, including one or more of the families of CDK proteins, and in particular, CDK12). More specifically, the present invention provides CDK12 inhibitors, of formula (I), pharmaceutically acceptable salts and isotopically labeled derivatives thereof, pharmaceutical compositions containing the compounds/inhibitors, and methods of their synthesis and use in treating proliferative diseases (e.g., a bladder cancer, a breast cancer, Ewing's sarcoma, a gastric cancer, a gastrointestinal cancer, a hematologic cancer, a lung cancer (e.g., small cell lung cancer (SCLC)), an ovarian cancer (e.g., a high grade serous ovarian cancer), a pancreatic cancer (e.g., pancreatic ductal adenocarcinoma (PDAC)), a brain cancer (e.g., glioblastoma), or a prostate cancer), alone or in combination with a second therapeutic agent. The proliferative disease can be a cancer, benign neoplasm, or pathologic angiogenesis, and any of the therapeutic methods or uses described herein can include a step of diagnosing the patient's disease. In other embodiments of the invention, the compositions described herein (e.g., the compounds, pharmaceutical compositions, and kits containing them) are used for the treatment of myotonic dystrophy (type 1 or type 2).

专利号:US-9683015-B2
优先权日:2012-01-03
标 题 :Peptide C alpha-amides, methods for preparing same and uses thereof as precursors of peptide C alpha-thioesters for protein synthesis
发明人：AUCAGNE VINCENT; DELMAS AGNÈS; ADIHOU HÉLÈNE
权利人:CENTRE NAT DE LA RECH SCIENTIFIQUE-CNRS
摘要:The subject matter of the present invention is peptide C α -amides which are precursors of peptide C α -thioesters, characterized in that they comprise the radical of general formula (I) in which X, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , n and A are as defined in Claim 1 . The subject matter of the present invention is also the use of these peptide C α -amides for obtaining peptide C α -thioesters. The subject matter of the present invention is also the use of these peptide C α -amides for obtaining peptides or proteins, in particular of therapeutic interest, by direct use as a crypto-thioester partner in NCL reactions.

专利号:EP-0600741-A1
优先权日:1992-12-04
标题:Synthesis of kainic acid

专利号:US-5352799-A
优先权日:1992-12-04
标 题:Intermediate compounds useful in the synthesis of kainic acid