CAS: 31938-07-5; 3-Bromobenzyl Cyanide

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CAS号60312-83-6 2-(3-溴苯基)乙酰胺 | CAS号328002-25-1 3-(3-bromo-phen... | CAS号151-50-8 氰化钾 | CAS号143433-71-0 sodium,(6R,7R)-... | CAS号185200-33-3 2-(3-溴-4-硝基苯基)乙酸甲酯 | CAS号29786-38-7 1-(3-溴苯基)环丁烷-1-甲腈 | CAS号297745-45-0 2-(3-bromopheny... | CAS号245439-36-5 4-(3-溴苯基)恶烷-4-腈 | CAS号1878-67-7 3-溴苯乙酸 | CAS号21906-32-1 3-溴苯丙酮 | CAS号28229-69-8 3-溴苯乙醇 | CAS号58971-11-2 间溴苯乙胺 | CAS号124840-61-5 2-(5-溴-2-硝基苯基)乙酸

2-(3-溴苯基)乙酰胺置于三乙胺,三氟乙酸酐体系中,用 1,4-二氧六环 用作溶剂,化学反应 12.0H,反应生成3-溴氰苄
参考文献:5-Lipoxygenase Inhibitors
标题:5-Lipoxygenase Inhibitors
摘要:本发明涉及5-脂氧酶抑制剂.本文所披露的化合物可用于治疗支气管哮喘,慢性阻塞性肺疾病,关节炎,1型糖尿病,多发性硬化症,移植排斥,银屑病,炎症性肠病,溃疡性结肠炎,痤疮,动脉粥样硬化,癌症,瘙痒,荨麻疹,特应性皮炎,过敏性鼻炎和其他炎症性和自身免疫性疾病的治疗.本文还提供了所披露化合物的制备方法,含有所披露化合物的制药组合物以及它们作为5-脂氧酶抑制剂的用途.

专利信息

专利号:US-10899695-B2
优先权日:2017-02-06
标 题 :Process for the synthesis of 1-aryl-1-trifluoromethylcyclopropanes
发明人：MCLAREN LEE; TO DANIEL; TOVELL DAVID; ABELE STEFAN
权利人:IDORSIA PHARMACEUTICALS LTD
摘要:The present invention relates to a process for the manufacturing of 1-aryl-1-trifluoromethylcyclopropanes, which serve as intermediates for the manufacturing of calcium T channel blockers of the general formula (A) n nwhich are described in WO 2015/186056.

专利号:RU-2181722-C2
优先权日:1998-12-22
标 题 :Method of synthesis and intermediate compounds for synthesis of 5-lipoxygenase inhibitors

专利号:US-2019375702-A1
优先权日:2017-02-06
标 题 :A novel process for the synthesis of 1-aryl-1-trifluoromethylcyclopropanes

专利号:US-4369322-A
优先权日:1978-12-15
标 题 :Process for the production of substituted acetonitriles
发明人：SCHALKE PETER; KLEEMANN AXEL
权利人:DEGUSSA
摘要:The known synthesis for the production of aromatic substituted acetonitriles by reaction of aromatic substances with cyanogen chloride in the gas phase is improved by feeding the starting materials in gaseous form and separated from each other into the reactor. The process can be used to synthesize in general aromatic and especially hetero-aromatic substituted acetonitrile.

专利号:WO-2018141961-A1
优先权日:2017-02-06
标题:A novel process for the synthesis of 1-aryl-1-trifluoromethylcyclopropanes

专利号:EP-3577099-B1
优先权日:2017-02-06
标 题 :A novel process for the synthesis of 1-aryl-1-trifluoromethylcyclopropanes