CAS: 31954-27-5; Boc-Gly-Ome

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1212-53-9 5680-79-5 2645-02-5

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CAS号24424-99-5 二碳酸二叔丁酯 | CAS号616-34-2 甘胺酸甲酯 | CAS号5680-79-5 甘氨酸甲酯盐酸盐 | CAS号1212-53-9 CBZ-甘氨酸甲酯 | CAS号1070-19-5 Carbonazidic ac... | CAS号4530-20-5 B°C-甘氨酸 | CAS号74-88-4 碘甲烷 | CAS号57218-61-8 allyl methyl ma... | CAS号75-65-0 叔丁醇 | CAS号67-56-1 甲醇 | CAS号35150-09-5 B°C-甘氨酰胺 | CAS号42492-57-9 N-B°C-N-甲基甘氨酸甲酯 | CAS号4530-20-5 B°C-甘氨酸 | CAS号183059-24-7 2-羟基-2-甲基丙基氨基甲酸叔丁酯 | CAS号89711-08-0 N-B°C-2-氨基乙醛 | CAS号26690-80-2 N-(叔丁氧羰基)乙醇胺 | CAS号5680-79-5 甘氨酸甲酯盐酸盐 | CAS号114703-81-0 (2-吗啉-4-基-2-氧代乙... | CAS号6926-09-6 B°C-甘氨酸酰肼 | CAS号13734-36-6 B°C-肌氨酸

Tert-Butyl (1-(Dimethyl(Phenyl)Silyl)-3-Methylbut-2-En-1-yl)Carbamate置于rhodium,Chlorobis(Triphenylphosphine)-,氧气,臭氧,Cesium Fluoride体系中,用 甲醇,二氯甲烷,N,N-二甲基甲酰胺,乙腈 作为反应溶剂,-78.0~100.0 °C,506.66 Kpa 条件下,反应 5.67H,反应生成 Boc-甘氨酸甲酯
参考文献:使用具有si-b键的双金属试剂从co 2一锅法合成α-氨基酸
标题:使用具有si-b键的双金属试剂从co 2一锅法合成α-氨基酸
摘要:在1.1当量的phme 2 Si-Bpin,5当量的csf和20摩尔%的tsoh.H2O存在下,N-Boc-亚胺的前体可以转化为相应的α-芳基或α-烯基甘氨酸一次操作即可在气态co 2下以中等至高收率得到各种衍生物.由此获得的α-异丁烯基甘氨酸可以在短时间内进一步衍生为各种类型的α-氨基酸,包括n-Boc-亮氨酸,丝氨酸和甘氨酸衍生物.
DOI:10.1021/ol302952R

专利信息

专利号:EP-1641729-B1
优先权日:2003-07-09
标题:Use of functionalized onium salts as a soluble support for organic synthesis
发明人：VAULTIER MICHEL; GMOUH SAID; HASSINE FATIMA
权利人:CENTRE NAT RECH SCIENT; UNIV RENNES
摘要:The invention relates to the use of a onium salt functionalized by at least one organic function, as a soluble support, in the presence of at least one organic solvent, for organic synthesis of a molecule, in a homogenous phase, by at least one transformation of said organic function. The onium salt enables the synthesized molecule to be released. The onium salt is present in liquid or solid form at room temperature and corresponds to formula A₁⁺, X₁^-, wherein A₁⁺ represents a cation and X₁^- represents an anion.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-7947722-B2
优先权日:2006-07-28
标 题:Imidazolidinone derivative, method of producing the same and method of producing optically active amino acid
发明人：SAKA YASUHIRO; FUJII AKIO; OKURO KAZUMI; MITSUDA MASARU
权利人:KANEKA CORP
摘要:The objective of the present invention is to provide an optically active imidazolidinone derivative widely usable for synthesizing an optically active amino acid, a method of easily producing the derivative, and a method of easily producing an optically active amino acid by using the derivative. The objective can be achieved by producing an optically active amino acid using a novel optically active imidazolidinone derivative represented by a general formula (3) and the like. According to the method of the present invention, an optically active imidazolidinone derivative can be obtained by preferential crystallization from a mixture of isomers of the imidazolidinone derivative. Therefore, an optically active amino acid can be easily and stereoselectively produced without cumbersome procedures required for the conventional methods, such as resolution of diastereomers, synthesis from an optically active amino acid and resolution of isomers by silica gel column chromatography.

专利号:US-2007043234-A1
优先权日:2003-07-09
标 题 :Use of functionalized onium salts as a soluble support for organic synthesis