CAS: 3378-82-3; 1-Bromo-2-Naphthaldehyde

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2-甲基萘置于盐酸,N-溴代丁二酰亚胺(Nbs),N4(Ch2)6,溴,溶剂黄146,过氧化苯甲酰体系中,用 二硫化碳,四氯化碳 用作溶剂,化学反应 3.0H,反应生成1-溴-2-萘甲醛
参考文献:一种新颖的包合物设计:通过联萘铰链和附加的配位基团选择性地包含不带电的分子.1,1'-联萘-2,2'-二羧酸主体/羟基客体包裹体的x射线晶体结构和结合模式
标题:一种新颖的包合物设计:通过联萘铰链和附加的配位基团选择性地包含不带电的分子.1,1'-联萘-2,2'-二羧酸主体/羟基客体包裹体的x射线晶体结构和结合模式
摘要:Etude De Cinq Clathrates Du Compose Du Titre (1) Avec Des Alcools Differents: 1.2 Meoh (P2 1 /n,Z=4),1.2 Etoh (C2/c,Z=4),1.2 (Proh-2) (C2/ C,Z=4),1.(Ruoh-2) (P2 1 /n,Z=4),1.乙二醇(P2 1 /n,Z=4).关系
Doi:10.1021/ja00323A039

专利信息

专利号:US-2024325572-A1
优先权日:2021-07-15
标 题 :N-heterocyclyl substituted 2-cyano-3-(naphthalen-2-yl)acrylamide derivatives as fluorophors for detection of amyloid and amyloid-like proteins for diagnosis of neurodegenerative disorders
发明人：SARRAF STELLA T
权利人:AMYDIS INC
摘要:Provided herein is the design and synthesis of novel molecular rotor fluorophores of formula I useful for detection of amyloid or amyloid like proteins. The fluorophores are designed to exhibit enhanced fluorescence emission upon associating with amyloid or amyloid like proteins as compared to unbound compound. Also disclosed herein are the compounds for use in methods for diagnosis and treatment of diseases associated with an amyloid or amyloid like proteins, such as e.g. Alzheimer's disease or traumatic brain injury (TBI), Parkinson's disease, vascular dementia, amyotrophic lateral sclerosis, Down syndrome, traumatic brain injury, chronic traumatic encephalopathy, schizophrenia or depression. Exemplary compounds are e.g. N-heterocyclyl substituted 2-cyano-3-(naphthalen-2-yl)acrylamide derivatives, such as e.g. (E)-2-cyano-N-(2-(2-hydroxy)ethoxy)ethyl)-3-(6-(pyrrolidin-1-yl)naphthalen-2-yl) acrylamide (example 1): Experimental data on in-vitro binding studies with amyloid beta is provided.

专利号:US-7696386-B2
优先权日:2006-09-29
标 题:Method of producing diol, polydiol, secondary alcohol or diketone compound
发明人：HOSONO HIDEO; BUCHAMMAGARI HARITHA; TODA YOSHITAKE; HIRANO MASAHIRO; OSAKADA KOHTARO; TAKEUCHI DAISUKE
权利人:JAPAN SCIENCE & TECH AGENCY
摘要:The invention is a process of using, as a reducing agent, a 12CaO.7Al 2 O 3 electride containing electrons in a number of 10 19 or more and 2.3×10 21 cm −3 or less in its cages to subject a carbonyl compound to reductive coupling in a solvent, thereby synthesizing a diol or polydiol. The invention is also a process of reducing a ketone compound in a solvent, thereby synthesizing a secondary alcohol or diketone compound. According to the process of the invention, it is possible to synthesize a diol or polydiol, or a secondary alcohol or diketone compound through simple operations in a short period without using an expensive and harmful metal hydride or metal salt nor limiting the atmosphere for the synthesis to an inert gas atmosphere as in conventional processes.

专利号:CN-106542971-B
优先权日:2015-09-17
标题:A kind of synthesis technology of the bromo- beta naphthal of 6-

专利号:CN-106111190-A
优先权日:2016-06-20
标 题 :A kind of chiral biaryl skeleton pyridoxamine catalyst and its synthesis method and application

专利号:CN-108947948-A
优先权日:2018-06-12
标 题 :A kind of N-aryl naphthofuran ketimine compound and its synthesis method