CAS: 5332-25-2; 6-Bromoquinoline

相似化合物

69268-39-9 5332-24-1 927801-13-6

上下游产品

glycerol 4-bromo-aniline acrolein 6-bromo-1-methanesulfonyl-1,2-dihydro-quinoline quinoline 6-aminoquinoline 6-bromoquinoline-2-ol 6-bromoquinoline-N-oxide

1,2,3,4-四氢喹啉置于2,3-二氯-5,6-二氰基-1,4-苯醌体系中,化学反应生成 6-溴喹啉
参考文献:区域选择性溴化:溴化甲氧基喹啉的合成
标题:区域选择性溴化:溴化甲氧基喹啉的合成
摘要:简单的合成方法为有价值的多官能溴化methoxyquinolines合成所述10-13,20-21,和24-25.描述了三种区域选择性途径,以方便地在c-2,C-3和c-5位置上使用分子溴在温和的反应条件下通过连续的反应步骤制备溴化甲氧基喹啉.在溴化6-溴-8-甲氧基-1,2,3,4-四氢喹啉(8)的同时选择性地得到3,6-二溴-8-甲氧基喹啉(10)和3,5,6-三溴-8-甲氧基喹啉(8).11),6,8-二甲氧基-1,2,3,4-四氢喹啉(9)导致形成3-Bromo-6,8-Dimethoxyqinoline(12)和tribromide 13.另一方面,直接溴化6-甲氧基-17和6,8-二甲氧基喹啉(19)得到5-溴衍生物20和21.然而,反应3,6-二甲氧基喹啉(8)导致二溴化形成2,5-二溴喹啉(24).此过程选择性地导致喹啉环在c-2和c-5位置均被官能化.
DOI:10.1016/j.Tet.2017.07.044

专利信息

专利号:US-2008119515-A1
优先权日:2003-03-10
标题:Heterocyclic Kinase Inhibitors: Methods of Use and Synthesis
发明人：SIDDIQUI M ARSHAD; BELANGER DAVID B; DAI CHAOYANG; ZHAO LIANYUN
权利人:SIDDIQUI M ARSHAD; BELANGER DAVID B; DAI CHAOYANG; ZHAO LIANYUN
摘要:Inhibitors of kinases, compositions including the inhibitors, and methods of using the inhibitors and inhibitor compositions are described. The inhibitors and compositions including them are useful for treating disease or disease symptoms. The invention also provides for methods of making kinase inhibitor compounds, methods of inhibiting kinase activity, and methods for treating disease or disease symptom.

专利号:WO-2004080463-A1
优先权日:2003-03-10
标题 :Heterocyclic kinase inhibitors: methods of use and synthesis
发明人：SIDDIQUI M ARSHAD; BELANGER DAVID; DAI CHAOYANG; ZHAO LIANYUN
权利人:NEOGENESIS PHARMACEUTICALS INC; SIDDIQUI M ARSHAD; BELANGER DAVID; DAI CHAOYANG; ZHAO LIANYUN
摘要:Inhibitors of kinases, compositions including the inhibitors, and methods of using the inhibitors and inhibitor compositions are described. The inhibitors and compositions including them are useful for treating disease or disease symptoms. The invention also provides for methods of making kinase inhibitor compounds, methods of inhibiting kinase activity, and methods for treating disease or disease symptom.

专利号:CN-107162968-B
优先权日:2017-05-25
标 题 :A kind of method of visible light catalytic Tetrahydroquinolinesas oxidative dehydrogenation synthesis of quinoline class compound

专利号:CN-111039910-A
优先权日:2019-12-31
标题 :A kind of method and application of photo-initiated synthesis of 3-aryl flavonoids or coumarin compounds

专利号:CN-115433125-A
优先权日:2022-09-15
标题 :A new method for the synthesis of 2-tert-butoxyquinoline derivatives

专利号:CN-113322490-A
优先权日:2020-02-28
标题:In situ synthesis of copper nanowire array material, preparation method and application thereof