3-乙酰基苯甲醛置于potassium Permanganate体系中,用 水,乙腈 作为反应溶剂,化学反应生成 3-乙酰基苯甲酸 参考文献:Electrophilicity And Nucleophilicity Of Commonly Used Aldehydes 标题:Electrophilicity And Nucleophilicity Of Commonly Used Aldehydes 摘要:目前用于确定醛类电亲和性(E)和核亲和性(N)的方法包括对kmno4氧化和nabh4还原醛类的动力学研究.对kmno4促进的醛氧化反应的过渡态分析表明,其与实验结果具有非常好的相关性.通过两种反应的实验活化参数验证了实验方法的有效性.通过理论与实验关系的进一步证明,该方法为各种醛类提供了便捷获取e和n值的途径,并能直观评估醛类在不同反应中的化学反应性. DOI:10.1039/c4Ob00555D
专利号:US-7737287-B2 优先权日:2002-03-28 标 题 :Anomeric derivatives of monosaccharides 发明人:MEUTERMANS WIM; WEST MICHAEL LEO; GIANG THANH LE; ADAMSON GEORGE; SCHAFER KARL; ABBENANTE GIOVANNI 权利人:ALCHEMIA LTD 摘要:This invention relates to combinatorial libraries of potentially biologically active mainly monosaccharide compounds and to methods of preparing same. These compounds are variously functionalized, with a view to varying lipid solubility, size, function and other properties, with the particular aim of discovering a drug or drug-like compound, or compounds with useful properties. The invention provides intermediates, processes and synthetic strategies for the solution or solid phase synthesis of monosaccharides, variously functionalized about the sugar ring, including the addition of aromaticity and charge, and the placement of amino acid and peptide side chain units of isosteres thereof.
专利号:WO-9426779-A1 优先权日:1993-05-13 标 题 :PROCESSES AND INTERMEDIATE COMPOUNDS USEFUL FOR THE PREPARATION OF PLATELET GLYCOPROTEIN IIb/IIIa INHIBITORS 发明人:MADUSKUIE THOMAS PETER JR 权利人:DU PONT MERCK PHARMA 摘要:This invention provides processes and intermediates for the synthesis of platelet glycoprotein IIb/IIIa inhibitors of formula (I).
专利号:US-5521179-A 优先权日:1991-04-18 标题 :Heterocyclic amides 发明人:BERNSTEIN PETER R; SHAW ANDREW; THOMAS ROYSTON M; WARNER PETER; WOLANIN DONALD J 权利人:ZENECA LTD 摘要:The present invention relates to certain novel heterocyclic amides which are 1-pyridylacetamide compounds of formula I, set out herein, which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these heterocyclic amides, processes for preparing the heterocyclic amides, pharmaceutical compositions containing such heterocyclic amides and methods for their use.
专利号:CN-105503565-A 优先权日:2016-01-04 标题 :A kind of one-pot synthesis method of m-acetylbenzoic acid
专利号:CN-111254457-A 优先权日:2020-03-31 标 题:Electrochemical synthesis method of aromatic carboxylic acid and alkyl carboxylic acid
专利号:CN-107709319-A 优先权日:2015-03-25 标 题:Synthesis process of substituted pyridopyrimidine compounds
[参考文献]: Yanong D Wang, Et Al. Synthesis, Sar Study And Biological Evaluation Of Novel Pyrazolo[1,5-A]Pyrimidin-7-Yl Phenyl Amides As Anti-Proliferative Agents. Bioorg Med Chem. 2009 Mar 1;17(5):2091-100.
合成参考文献
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