CAS: 60965-26-6; 2-Bromo-1-(2,4-Dimethoxyphenyl)Ethanone

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CAS号829-20-9 2,4-二甲氧基苯乙酮 | CAS号598-21-0 溴乙酰溴 | CAS号151-10-0 间苯二甲醚 | CAS号590-17-0 溴乙腈 | CAS号23111-45-7 4-(2,4-二甲氧基苯基)-... | CAS号829-20-9 2,4-二甲氧基苯乙酮 | CAS号823829-25-0 1-(2,4-dimethox... | CAS号823829-27-2 1-(2,4-dimethox... | CAS号92754-07-9 6-(2,4-dimethox... | CAS号92754-34-2 6-(2,4-dimethox... | CAS号93276-54-1 2-(2,4-dimethox... | CAS号4783-90-8 2-氯-1-(2,4-二甲氧基苯基)乙酮

2,4-二甲氧基苯乙酮置于copper(Ll) Bromide体系中,用 氯仿,乙酸乙酯 作为反应溶剂,化学反应 10.0H,以80%的收率获得产物2-溴-2,4-二甲氧基苯乙酮
参考文献:打开或关闭锁当反应性是生物活性的关键时
标题:打开或关闭锁当反应性是生物活性的关键时
摘要:硫醇介导的过程在诱导或抑制炎症蛋白中起关键作用.调整亲电试剂的反应性可以提高仅处理某些表面半胱氨酸的选择性.14个带有不同α-X取代基的2',3,4,4'-四甲氧基查con(x = H,F,Cl,Br,I,Cn,Me,P-No 2-C 6 H 4,Ph,P-Ome ‐c 6 H 4,No 2,Cf 3,Cooet,Cooh)合成,其中包含潜在的亲电性α,β-不饱和羰基单元.硫代-迈克尔加半胱胺中它们作为亲电子试剂的反应性评估显示,反应性变化超过六个数量级.此外,还证明了它们的反应性与对炎症蛋白血红素加氧酶-1(ho-1)和诱导型一氧化氮合酶(inos)的影响之间存在明显的相关性.作为生物最活跃化合物,α-Cf 3-Chalcone被显示抑制no反应生成raw264.7小鼠巨噬细胞在纳摩尔范围内.
DOI:10.1002/chem.201302117

专利信息

专利号:US-7566697-B2
优先权日:2002-06-10
标题 :Carboxy protection strategies for acidic C-terminal amino acids in chemical ligation of oligopeptides
发明人：BOTTI PAOLO; VILLAIN MATTEO; MANGANIELLO SONIA; GAERTNER HUBERT
权利人:AMYLIN PHARMACEUTICALS INC
摘要:The present invention provides methods of assembling oligopeptides or polypeptides in a native chemical ligation reaction that eliminates the formation of unwanted side products resulting from the presence of an unprotected acidic C-terminal oligopeptide thioester. An important aspect of the present invention is providing side chain protected acidic C-terminal oligopeptide thioesters. The present invention is useful in methods for chemical synthesis of oligopeptides, polypeptides and proteins and improves the efficiency of native chemical ligation reactions, particularly where aspartyl or glutamyl peptide fragments are used to assemble an oligopeptide, polypeptide or protein product.