(-)-Vibo-栎醇置于三氟甲磺酸三甲基硅酯体系中,化学反应 19.0H,反应生成 1,2,4-苯三酚醋酸酯 参考文献:Transformation Of Quercitols Into 4-Methylenecyclohex-5-Ene-1,2,3-Triol Derivatives,Precursors For The Chemical Chaperones N-octyl-4-Epi-β-Valienamine (Noev) And N-octyl-β-Valienamine (Nov) 标题:Transformation Of Quercitols Into 4-Methylenecyclohex-5-Ene-1,2,3-Triol Derivatives,Precursors For The Chemical Chaperones N-octyl-4-Epi-β-Valienamine (Noev) And N-octyl-β-Valienamine (Nov) 摘要:(+)-原儿茶糖苷醇(1)和(-)-威博儿茶糖苷醇(2),这两种糖苷均可以通过肌醇的生物转化简便制备,成功转化为了相应的4-甲基环己-5-烯-1,2,3-三醇衍生物.研究证明,这些化合物在保留其构型的情况下,适合作为具有生物活性的氨基糖(如强效化学伴侣药物候选物n-辛基-4-表-β-戊吡胺醇(3)和n-辛基-β-戊吡胺醇(4))的前体. (以上译文仅供参考,英文原文版权为2011 Elsevier Ltd.所有,保留所有权利.) DOI:10.1016/j.Bmcl.2011.09.067
专利号:US-12247239-B2 优先权日:2019-06-21 标题:Chemo-enzymatic process for the preparation of homopropargylic alcohol 发明人:CHANDRASEKHAR SRIVARI; GHOSH SUBHASH; KRISHNA AVULA SHIVA; REDDY CHADA RAJI; SUDHAKAR GANGARAJULA; THENKRISHNAN KUMARAGURU; PABBARAJA SRIHARI; MAINKAR PRATHAMA SATYENDRA; NASAM RAJESH 权利人:COUNCIL SCIENT IND RES; COUNCIL SCIENT IND RES 摘要:The present invention relates to an enzymatic process for preparation of optically pure enantiomers of homopropargylic alcohol compounds of formula I, which are useful intermediates for the synthesis of Halichondrin B and analogs. wherein, P is H or an alcohol protecting group, n is an integer ranging from 0-12.
专利号:WO-0056911-A1 优先权日:1999-03-23 标题 :Synthesis of 1,2,3,4-tetrahydroxybenzenes and 1,2,3-trihydroxybenzenes using myo-inositol-1-phosphate synthase and myo-inositol 2-dehydrogenase
专利号:US-9963476-B2 优先权日:2015-02-19 标题 :Antioxidant compound having anti atherosclerotic effect and preparation thereof 发明人:SRIGIRIDHAR KOTAMRAJU; SANTOSH KARNEWAR; BABU VASAMSETTI SATHISH; KUMAR TOGAPUR PAVAN; Reddy Basi Venkata Subba; Kumar Jerald Mahesh 权利人:COUNCIL SCIENT IND RES 摘要:The present invention relates to an antioxidant compound having anti atherosclerotic effect and preparation thereof. The present invention more particularly relates to the synthesis of TPP+ coupled esculetin (mitochondria-targeted esculetin [Mito-Esc]) followed by the biological evaluation of Mito-Esc for its ability to attenuate Angiotensin-II-induced atherosclerosis in apolipoproteinE knockout (ApoE −/− mice along with the endothelial cell age-delaying effects of Mito-Esc.
专利号:CA-2640585-A1 优先权日:2003-02-05 标题 :Synthesis of 2-butyl-3-(2'-(1-trityl-1h-tetrazol-5-yl)biphenyl-4-yl)-1,3-diazaspirol{4,4}-non-ene-4-one
专利号:CA-2366222-A1 优先权日:1999-03-23 标 题:Synthesis of 1,2,3,4-tetrahydroxybenzenes and 1,2,3-trihydroxybenzenes using myo-inositol-1-phosphate synthase and myo-inositol 2-dehydrogenase
专利号:US-6287798-B1 优先权日:1996-05-01 标题 :Esculetin derivatives 发明人:JAMES ARTHUR; ARMSTRONG LYLE 权利人:IDG UK LTD 摘要:The invention concerns novel 6- or 7-substituted derivatives of esculetin (6,7-dihydroxy-2H-1-benzopyran-2-one), their synthesis, and their application as substrates for the detection of micro-organisms in samples where a derivative is enzymatically cleaved to release a colored or fluorogenic marker which has a low tendency to diffuse through agar or other aqueous environments.
[参考文献]: Nataly D Pokhilo, Et Al. Synthesis Of Echinamines A And B, The First Aminated Hydroxynaphthazarins Produced By The Sea Urchin Scaphechinus Mirabilis And Its Analogues. J Nat Prod. 2006 Aug;69(8):1125-9.
合成参考文献
摘要:S13 | EUCOSMETICS | Combined Inventory of Ingredients Employed in Cosmetic Products (2000) and Revised Inventory (2006) | DOI:10.5281/zenodo.2624118 参考文献:10.1038/nchem.1506 摘要:Over B, Wetzel S, Grütter C, Nakai Y, Renner S, Rauh D, Waldmann H. Natural-product-derived fragments for fragment-based ligand discovery. Nat Chem. 2013 Jan;5(1):21–8. doi: 10.1038/nchem.1506. 参考文献:10.1021/np0502185 摘要:Pokhilo ND, Shuvalova MI, Lebedko MV, Sopelnyak GI, Yakubovskaya AY, Mischenko NP, Fedoreyev SA, Anufriev VP. Synthesis of Echinamines A and B, the First Aminated Hydroxynaphthazarins Produced by the Sea Urchin Scaphechinus mirabilis and Its Analogues. J. Nat. Prod. 2006 Jul 19;69(8):1125–9. doi: 10.1021/np0502185.