CAS: 6746-94-7; Cyclopropyl Acetylene

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CAS号765-43-5 环丙甲基酮 | CAS号14267-92-6 5-氯-1-戊炔 | CAS号21369-64-2 正己基锂 | CAS号1187885-13-7 (1-cyclopropylv... | CAS号58822-70-1 1,1-dichloro-2-... | CAS号40459-85-6 1,1-dichloroeth... | CAS号75522-03-1 Spiro[2.2]penta... | CAS号122244-78-4 1-(2,2-DIBROMOE... | CAS号24154-06-1 1-chlorovinylcy... | CAS号1123725-69-8 3-环丙基吡咯-2-甲酸乙酯 | CAS号436097-28-8 (3,3-二甲氧基-1-丙炔基)环丙烷 | CAS号21080-81-9 5-环丙基异噁唑-3-甲酸乙酯 | CAS号216006-64-3 magnesium,ethyn... | CAS号19714-73-9 1-环丙基-3-甲基苯 | CAS号6921-43-3 1-环丙基-4-甲基苯 | CAS号201218-09-9 lithium,ethynyl... | CAS号21024-57-7 methyl 3-cyclop... | CAS号214287-90-8 (4S)-4-(2-cyclo... | CAS号91-20-3 萘

环丙甲基酮置于aluminum Oxide,正丁基锂体系中,化学反应 7.0H,反应生成 环丙乙炔
参考文献:一种含炔基环丙化合物的制备方法
标题:一种含炔基环丙化合物的制备方法
摘要:本发明涉及有机合成领域,公开了一种含炔基环丙化合物的制备方法,以烯炔烃化合物ii为起始原料,在催化剂作用下,在溶剂中与重氮物iv混合反应,得到含有化合物iii的反应液;将所得反应液加入酸水或热水中洗涤,再加入无机碱或有机碱调节ph至8~14,制得炔基环丙化合物i.本发明方法具有以下有益效果:1)提高反应的收率;2)使用廉价易得的工业化原料;3),减少副产物,减少环境污染.

专利信息

专利号:US-2001044540-A1
优先权日:2000-03-23
标 题:Asymmetric synthesis of quinazolin-2-ones useful as HIV reverse transcriptase inhibitors
发明人：PARSONS RODNEY L; DOROW ROBERTA L; DAVULCU AKIN H; FORTUNAK JOSEPH M; HARRIS GREGORY D; KAUFFMAN GOSS S; NUGENT WILLIAM A; RADESCA LILIAN A
摘要:This invention relates generally to the asymmetric synthesis of quinazolin-2-ones that are useful as inhibitors of HIV reverse transcriptase. The synthesis is accomplished through the chiral ligand mediated addition of cyclopropylacetylide.

专利号:US-2025026768-A1
优先权日:2023-06-30
标题:Method for the synthesis of axially chiral organoboron compounds
发明人：PING YIFAN; CHE CHI-MING
权利人:LABORATORY FOR SYNTHETIC CHEMISTRY AND CHEMICAL BIOLOGY LTD
摘要:A highly efficient and atroposelective Rh-catalyzed [2+2+2] cycloaddition for the synthesis of axially chiral aryboron compounds is developed. The reactions of diynes and alkynylborons smoothly occur in an atom-economical manner, affording a variety of C—B atropisomers in excellent yields and enantioselectivities. The protocol features mild conditions, broad substrate scope, and good functional tolerance. The obtained C—B atropisomers show powerful synthetic applications in terms of producing novel chiral phosphine ligands.

专利号:US-6555686-B2
优先权日:2000-03-23
标题:Asymmetric synthesis of quinazolin-2-ones useful as HIV reverse transcriptase inhibitors
发明人：PARSONS RODNEY L; DOROW ROBERTA L; DAVULCU AKIN H; FORTUNAK JOSEPH M; HARRIS GREGORY D; KAUFFMAN GOSS S; NUGENT WILLIAM A; RADESCA LILIAN A
权利人:BRISTOL MYERS SQUIBB PHARMA
摘要:This invention relates generally to the asymmetric synthesis of quinazolin-2-ones that are useful as inhibitors of HIV reverse transcriptase. The synthesis is accomplished through the chiral ligand mediated addition of cyclopropylacetylide.

专利号:US-6028237-A
优先权日:1996-12-16
标题:Synthesis of cyclopropylacetylene
发明人：PARSONS JR RODNEY LAWRENCE
权利人:DU PONT PHARM CO
摘要:The present invention relates generally to novel methods for the synthesis of cyclopropylacetylene which is a reagent in the asymmetric synthesis of (S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one which is a useful human immunodeficiency virus (HIV) reverse transcriptase inhibitor.

专利号:US-7217851-B1
优先权日:2004-03-31
标 题:Synthesis of butadiynes
发明人：SURI SURESH C; TINNIRELLO MICHAEL G
权利人:US AIR FORCE
摘要:Provided is a method for the synthesis of 1,4-dicyclopropyl-1,3-butadiyne from CPA. Such butadiyne is prepared by oxidative coupling of cyclopropyl acetylene (CPA) using catalytic amounts each of copper (I)chloride and tetrametylethylenediamine (TMEDA) in isopropanol under aerobic conditions. The resulting butadiyne can serve as a fuel or a fuel additive for combustion in engines propelling motor vehicles, marine vessels, aircraft, rockets and other vehicles.

专利号:US-5698741-A
优先权日:1995-05-25
标题 :Asymmetric synthesis of (-)6-chloro-4-cyclopropyl-ethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one
发明人：THOMPSON ANDREW S; CORLEY EDWARD G; GRABOWSKI EDWARD J J; YASUDA NOBUYOSHI
权利人:MERCK & CO INC
摘要:An improved synthesis of a highly potent HIV reverse transcription inhibitor is disclosed, involving an acetylide and a trifluoromethyl ketone which produces a chiral product in the presence of a chiral amino alcohol.