CAS: 7365-44-8; N-Tris(Hydroxymethyl)Methyl-2-Aminoethanesulfonic Acid

上下游产品

1-Bromo-2-chloroethane 2-amino-2-hydroxymethyl-1,3-propanediol

1-溴-2-氯乙烷,三羟甲基氨基甲烷置于sodium Hydroxide,铜,Sodium Sulfite体系中,用 水 作为反应溶剂,化学反应 20.0H,以87%的收率获得产物2-[[三(羟甲基)甲基]氨基]乙磺酸
参考文献:一种2-[[三(羟甲基)甲基]氨基]乙磺酸的制 备方法
标题:一种2-[[三(羟甲基)甲基]氨基]乙磺酸的制 备方法
摘要:本发明公开了一种2‑[[三(羟甲基)甲基]氨基]乙磺酸的制备方法,包括如下步骤:将三羟基甲基氨基甲烷与1,2‑二卤代乙烷溶于溶剂中,在搅拌下,加热升温至回流反应,控制溶液的ph值>=7.0,得到第一中间反应液;将亚硫酸钠加入第一中间反应液中,在催化剂的作用下,加热升温至回流反应,得到第二中间反应液;将第二中间反应液经过降温,过滤后,然后加入阳离子交换树脂,进行吸附,再经过脱溶剂,结晶处理后,得到2‑[[三(羟甲基)甲基]氨基]乙磺酸.本发明采用两步一锅法合成,其反应的收率高,后处理工艺简便,产品纯度好,同时克服了使用2‑卤代乙磺酸所带来的低收率或者三废的问题.

专利信息

专利号:US-10501782-B1
优先权日:2014-09-05
标题:Cell-free synthesis of DNA by strand displacement
发明人：PORTER NEIL; ROTHWELL PAUL; EXTANCE JONATHAN
权利人:TOUCHLIGHT IP LTD
摘要:The present invention relates to an improved process for synthesis of DNA, RNA, proteins and like molecules, in particular cell-free enzymatic synthesis of DNA, preferably in large scale. The present invention relates to the synthesis of DNA using strand-displacement replication and the addition of nucleotides to the reaction mixture is controlled, thus controlling yield. The reaction mixture contains a starting amount of nucleotides, polymerase and DNA template, to which further nucleotides are supplied in a controlled manner.

专利号:WO-2022256490-A9
优先权日:2021-06-03
标题:Improved synthesis of phosphoramidates for the treatment of hepatitis b virus
发明人：LOCKWOOD MARK
权利人:ANTIOS THERAPEUTICS INC
摘要:The synthesis of phosphoramidate prodrugs useful in the treatment of viral infections is disclosed. Specifically, an improved synthesis of phosphoramidate nucleotides useful in the treatment of Hepatitis B virus is disclosed.

专利号:US-2024092821-A1
优先权日:2020-03-31
标题:Synthesis of oligonucleotides and related compounds
发明人：ZHONG MINGHONG; JIN YI; GALA DINESH; PRHAVC MARIJA
权利人:JANSSEN BIOPHARMA INC
摘要:Methods of synthesizing oligonucleotides via new intermediates on a cleavable support having an azidomethyl moiety are disclosed. The method comprises multiple reaction cycles, each of which comprises sequential coupling a nucleoside or oligonucleotide subunit on a cleavable support having an azidomethyl moiety and a nucleoside phosphoramidite or an oligonucleotide phosphoramidite, capping, oxidation/thiolation and deblocking; followed by orthogonal cleavage of the azidomethyl support while keeping all other protecting groups intact. The method can be used in combination with a support moiety for either solid phase or liquid phase oligo synthesis. The soluble support facilitates homogeneous reactions and efficient separations by simple precipitation. The methods also provide novel intermediates useful in the synthesis of oligonucleotide conjugates.

专利号:US-11447454-B2
优先权日:2015-08-07
标题:Synthesis of benzodiazepine derivatives
发明人：BOYCE MALCOLM JAMES; THOMSEN LIV; GILBERT DONALD ALAN; WOOD DAVID
权利人:TRIO MEDICINES LTD
摘要:The invention relates to processes for the synthesis of benzodiazepine derivatives of Formula I:

专利号:US-8420848-B2
优先权日:2009-01-09
标题:Process for the synthesis of beta glycerol phosphate
发明人：KULKARNI YASHWANT
权利人:KULKARNI YASHWANT; SIGMA ALDRICH CO LLC
摘要:The present invention provides methods for the preparation of beta glycerol phosphate and its salts. In particular, the invention provides efficient methods for the synthesis of beta glycerol phosphate of high purity.

专利号:US-7255989-B1
优先权日:1999-11-29
标 题:Method for obtaining nucleic acids from an environment sample, resulting nucleic acids and use in synthesis of novel compounds
发明人：JEANNIN PASCALE; PERNODET JEAN-LUC; GUERINEAU MICHEL; SIMONET PASCAL; COURTOIS SOPHIE; CAPPELLANO CAMELA; FRANCOU FRANCOIS; RAYNAL ALAIN; BALL MARIA; SEZONOV GUENNADI; TUPHILE KARINE; FROSTEGARD ASA
权利人:AVENTIS PHARMA SA
摘要:The invention concerns a method for preparing nucleic acids from an environment sample, more particularly a method for obtaining a library of nucleic acids from a sample. The invention also concerns nucleic acids of nucleic acid libraries obtained by said method their use in the synthesis of novel compounds, in particular novel compounds of therapeutic interest. The invent further concerns novel means used in the method for obtaining said nucleic acids, such as novel vectors and novel processes for preparing such vectors or recombinant host cells containing said nucleic acid. Finally, the invention concerns methods for detecting a nucleic acid of interest within a library of nucleic acids resulting from said method, and nucleic acids detected by said method and polypeptides encoded by said nucleic acids.