CAS: 923-27-3; D-Lysine

• 英文名称D-Lysine
• 中文名称D-赖氨酸
• IUPAC名称(2R)-2,6-diaminohexanoic acid
• 其它别名(R)-2,6-Diaminohexanoic acid
• CAS编号923-27-3
• MFCD编号:MFCD00008234
• EINECS号:213-091-9
• 分子式:C6H14N2O2
• 分子量:146.187
• 产品CID: 1961102
• 产品分类有机原料→生命科学→氨基酸及其衍生物→赖氨酸及其衍生物

• 相似结构搜索
• 产品信息参考;;;;
• InChIKey: KDXKERNSBIXSRK-RXMQYKEDSA-N
• InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/t5-/m1/s1…
• 计算化学: 氢键受体数3.0氢键供体数3.0可旋转键数5.0

相似化合物

物理性质

• 熔点218°C
• 沸点311.5°C at 760 mmHg
• 闪点142.2±25.1 °C
• 密度1.1±0.1 g/cm3
• pKa:2.49±0.24(预测)
• PSA:89.34
• LogP:-0.4727
• 折射率1.503
• 蒸汽压0.0±1.4 mmHg at 25°C
• 溶解性水: Soluble
• 敏感性常温常压下稳定 针状或片状结晶。溶于水、酸，微溶于乙醇、乙醚、氯仿。熔点224°C（分解）。比旋光度[α]D25 －25.9°（C=2，0.5mol/L盐酸中）、－13.5°（C=2，水中）。
• 外观形态类白色至浅米色固体
• 储存条件-20°C

MSDS等安全信息

• GHS符号GHS07
• 警示词Warning
• 危险描述H302-H315-H319-H335
• 防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
• UN编号NONH for all modes of transport
• WGK Germany3

上下游产品

合成工艺路线路线简述

• 合成目标产物 D-Lysine 主要起始原料 N6-Benzoyl-Dl-Lysine
• 1615215-44-5 = 923-27-3
  反应条件:1.1 Catalysts: Ammonium Hydroxide Solvents: Methanol,Water; Rt
  标题:Chemical Dynamic Kinetic Resolution And S/r Interconversion Of Unprotected α-Amino Acids
  作者:Takeda,Ryosuke; Kawamura,Akie; Kawashima,Aki; Sato,Tatsunori; Moriwaki,Hiroki; Et Al
  参考文献:Angewandte Chemie 日期:2014 卷标:53(45) 页码:12214-12217]
  
  = 923-27-3
  反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Water; 6 H,Rt
  标题:Selective Synthesis Applying Amino Acids With Basic Side Chains As Peptide Precursors
  作者:Kuhler,Jeanne L.; Brooks,Robey T.; Helms,Whitney K.; Hodge,Monica; Holly,Krystal D.; Et Al
  参考文献:African Journal Of Pure And Applied Chemistry 日期:2009 卷标:3(6) 页码:108-115]
  
  = 923-27-3
  反应条件:1.1 Reagents: Ammonia Catalysts: Copper,[tris(3,5-Dimethyl-1H-Pyrazolato-Kn1)Hydroborato(1-)-Kn2,Kn2′,Kn2′′]-,(2R)-2-[[[[3,5-Bis(Trifluoromethyl)Phenyl]Amino]Thioxomethyl]Amino]-3,3-Dimethyl... Solvents: Tert-Butyl Methyl Ether; 10 H,40 °C1.2 Reagents: Hydrochloric Acid Solvents: Tetrahydrofuran,Water; 16 H,Rt
  标题:Enantioselective Synthesis Of Amino Acids From Ammonia
  作者:Li,Mao-Lin; Pan,Jia-Bin; Zhou,Qi-Lin
  参考文献:Nature Catalysis 日期:2022 卷标:5(6) 页码:571-577]
  
  70-54-2 = 923-27-3
  反应条件:1.1 Solvents: Water; 72 H,30 °C1.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 2 - 31.3 Reagents: (+/-)-Propylene Oxide Solvents: Ethanol; 30 Min,Rt
  标题:Preparation Of D-Amino Acid Via Enzymic Resolution Of Dl-Amino Acid
  参考文献:China]
  
  29070-06-2 = 923-27-3 [标题:Reaction Conditions
  标题:D-α-Amino Acids
  参考文献:Federal Republic Of Germany]
  
  56-87-1 = 923-27-3
  反应条件:1.1 Reagents: Sodium Chloride Catalysts: Lysine Racemase Solvents: Water; Ph 7.0,37 °C
  标题:Gel Type Biocatalyst,Preparation Method,And Application In D-Lysine Production
  参考文献:China]
  
  56-87-1 = 923-27-3
  反应条件:1.1 Catalysts: Lysine Racemase; Rt
  标题:Functional Expression Of L-Lysine α-Oxidase From Scomber Japonicus In Escherichia Coli For One-Pot Synthesis Of L-Pipecolic Acid From Dl-Lysine
  作者:Tani,Yasushi; Miyake,Ryoma; Yukami,Ryoichi; Dekishima,Yasumasa; China,Hideyasu; Et Al
  参考文献:Applied Microbiology And Biotechnology 日期:2015 卷标:99(12) 页码:5045-5054]
  
  70671-54-4 = 923-27-3
  反应条件:1.1 18 - 20 H,42 °C1.2 Reagents: Trifluoroacetic Acid Solvents: Acetonitrile; 42 °C
  标题:Enantioselective Enzymatic Cleavage Of N-Benzyloxycarbonyl Groups
  作者:Patel,Ramesh N.; Nanduri,Venkata; Brzozowski,David; Mcnamee,Clyde; Banerjee,Amit
  参考文献:Advanced Synthesis & Catalysis 日期:2003 卷标:345 页码:830-834]
  
  70-54-2 = 923-27-3 [标题:Reaction Conditions
  标题:General Evaluation And Application To Trace Analysis Of A Chiral Column For Ligand-Exchange Chromatography
  作者:Kiniwa,Hideaki; Baba,Yuka; Ishida,Tomoko; Katoh,Hiromasa
  参考文献:Journal Of Chromatography 日期:1989 卷标:461 页码:397-405]
  
  29070-06-2 = 923-27-3 [标题:Reaction Conditions
  标题:Enzymic Production Of D-Amino Acids From 5-Substituted Hydantoins. Part Ii. Optimal Conditions For The Enzymic Production Of D-Amino Acids From The Corresponding 5-Substituted Hydantoins
  作者:Yokozeki,Kenzo; Nakamori,Shigeru; Yamanaka,Shigeru; Eguchi,Chikahiko; Mitsugi,Koji; Et Al
  参考文献:Agricultural And Biological Chemistry 日期:1987 卷标:51(3) 页码:715-19]
  
  70-54-2 = 923-27-3
  反应条件:1.1 Reagents: (αs)-α-Methylbenzenemethanesulfonic Acid,α-Methyl-4-Nitrobenzenemethanesulfonic Acid Solvents: Methanol,Water; 5 H,Reflux; Reflux -> 75 °C1.2 Reagents: Sodium Hydroxide Solvents: Methanol,Water; Ph 9.74; 1 H
  标题:Process For Preparation Of Optically Active Amino Acids
  参考文献:China]
  
  657-27-2 = 923-27-3
  反应条件:1.1 105 H,135 °C
  标题:Greener Approach To Leather Tanning Process: D-Lysine Aldehyde As Novel Tanning Agent For Chrome-Free Tanning
  作者:Krishnamoorthy,Ganesan; Sadulla,Sayeed; Sehgal,Praveen Kumar; Mandal,Asit Baran
  参考文献:Journal Of Cleaner Production 日期:2013 卷标:42 页码:277-286]
  
  70-53-1 = 923-27-3
  反应条件:1.1 Solvents: Water
  标题:Preparation Of Dl-Lysine Linear Dimer For Quality Control Of Aspirin-Dl-Lysine
  参考文献:China]
  
  70-54-2 = 923-27-3
  反应条件:1.1 Reagents: Phenylacetyl Chloride,Sodium Hydroxide Solvents: Water; Ph 8 - 10,10 °C; 2 H,10 °C; 6 H,Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 1 - 21.3 Reagents: Sodium Hydroxide,Penicillin Amidase Solvents: Water; 12 H,30 °C1.4 Reagents: Hydrochloric Acid Solvents: Water; Ph 1 - 2; 5 H,120 °C1.5 Reagents: Ammonia Solvents: Water; Overnight,Ph 5.74,4 °C
  标题:Method For Preparing D-Amino Acid With Immobilized Penicillin Acylase As Catalyst
  参考文献:China]
  
  56-87-1 = 923-27-3
  反应条件:1.1 Reagents: Triethylamine Catalysts: 3-Hydroxy-2-Methyl-5-[(Octyloxy)Methyl]-4-Pyridinecarboxaldehyde Solvents: Water; 18 H,20 - 25 °C
  标题:Preparation Of Racemic α-Amino Acid Standards For Accurate Mass Spectrometric Analysis Via Racemization Catalyzed By A Hydrophobic Pyridoxal Derivative
  作者:Harada,Masashi; Shimbo,Kazutaka; Karakawa,Sachise
  参考文献:Talanta 日期:2021 卷标:234]
  
  70-54-2 = 923-27-3
  反应条件:1.1 Catalysts: Zinc Nitrate (Complexes With Acrylic Acid-Styrene-Me Methacrylate Copolymer),Acrylic Acid-Methyl Methacrylate-Styrene Copolymer (Complexes With Zinc Nitrate) Solvents: Water; 12 H,Rt
  标题:Chiral Organic Metal Skeleton Hollow Nanosphere And Preparation Method Thereof
  参考文献:China]
  
  87-69-4 + 923-27-3 = 923-27-3
  反应条件:1.1 Reagents: Calcium Hydroxide Solvents: Water; Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 5.5 - 6
  标题:Process For Preparation Of D-Lysine Hydrochloride
  参考文献:China]
  
  923-27-3 + 35963-20-3 = 923-27-3
  反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Water; Ph 0.5 - 1.5
  标题:Process For Preparation Of D-Lysine Hydrochloride
  参考文献:China]
  
  1155-64-2 = 923-27-3
  反应条件:1.1 Reagents: Trifluoroacetic Acid Solvents: Acetonitrile; 18 - 20 H,42 °C
  标题:Enzymic Deprotection Of Amines And Hydroxides
  参考文献:World Intellectual Property Organization]
  
  10606-14-1 = 923-27-3
  反应条件:1.1 Reagents: Nadh,D-Alanine,D-Lactic Acid Catalysts: D-Amino Acid Aminotransferase Solvents: Water; Ph 8.3,37 °C
  标题:Preparation Of Enantiomerically Pure D-Amino Acids By Fermentative With Transgenic Cells
  参考文献:United States

海关参考信息

• 2905121000-正丙醇
  2905130000-正丁醇
  2912110000-甲醛
  2912120000-乙醛
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• ➥ 象形图和危险代码
• ➥ 防范代码详解
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