CAS: 927-67-3; 1-Propylthiourea

该化合物是一种有机化合物,其分子式为C4H10N2S,主要以其作为硫尿素衍生物的作用而得到承认,它具有明显的含硫有机基质,经常用于化学合成和协调化学,因为它能够形成稳定的金属离子复合体.Propylthiourea还被用于研究应用,特别是用于有关酶抑制和硫醇再活性的研究,其结构特征,包括丙基类和硫尿素细胞,有助于其在极地溶剂中的溶解性,以及核生殖器替代反应中的再活性.该化合物由于潜在的毒性而得到谨慎处理,通常储存在受控制的条件下,以确保稳定性.

结构式图片

相似化合物

26536-60-7 109-46-6 625-53-6

欧盟法规

ECHA物质ECHA物质C&L通报REACH预注册

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CAS号628-30-8 异硫氰酸丙酯 | CAS号29337-33-5 N-(n-propyl)-N'... | CAS号107-10-8 丙胺 | CAS号625-57-0 O-乙基硫代氨基甲酸酯

合成工艺路线路线简述

  • 合成目标产物 N-Propylthiourea 主要起始原料 Propyl Isothiocyanate
  • (文献来源)合成步骤主要原料 Propyl Isothiocyanate
异氰酸丙酯置于氨体系中,用 乙醇 作为反应溶剂,化学反应 0.17H,反应生成 正丙基硫脲
参考文献:Fatimi; Lagorce; Chabernaud,Bollettino Chimico Farmaceutico,1994,Vol. 133,# 3,P. 151-155
标题:Fatimi; Lagorce; Chabernaud,Bollettino Chimico Farmaceutico,1994,Vol. 133,# 3,P. 151-155

海关参考信息

专利信息


专利号:US-4627968-A
优先权日:1984-09-10
标 题 :Synthesis of crystalline aluminosilicate with alkylurea or alkylthiourea
发明人:KAI TADASHI
权利人:ASAHI CHEMICAL IND
摘要:In the synthesis of a crystalline aluminosilicate by heating an aqueous mixture containing a silica source, an alumina source and an alkali metal source, at least one compound selected from lower alkylureas and lower alkylthioureas is permitted to co-exist with the mixture.

专利号:US-2008004415-A1
优先权日:2004-05-03
标题 :Non-linear optically active molecules, their synthesis, and use
发明人:MCGINNISS VINCENT D; RISSER STEVEN M; DROTLEFF ELIZABETH; JIANG EDWARD; SPAHR KEVIN B
权利人:OPTIMER PHOTONICS INC
摘要:In one aspect, the present invention provides a hyperpolarizable organic chromophore. The chromophore is a nonlinear optically active compound that includes a Ï€-donor conjugated to a Ï€-acceptor through a Ï€-electron conjugated bridge. In other aspects of the invention, donor structures and acceptor structures are provided. In another aspect of the invention, a chromophore-containing polymer is provided. In one embodiment, the chromophore is physically incorporated into the polymer to provide a composite. In another embodiment, the chromophore is covalently bonded to the polymer, either as a side chain polymer or through crosslinking into the polymer. In other aspects, the present invention also provides a method for making the chromophore, a method for making the chromophore-containing polymer, and methods for using the chromophore and chromophore-containing polymer.

专利号:US-4656291-A
优先权日:1985-03-15
标 题 :Process for producing amidine sulfonic acids
发明人:MARYANOFF CYNTHIA A; PLAMPIN JAMES N; STANZIONE ROBIN C
权利人:MCNEILAB INC
摘要:An efficient synthesis of quanidines, e.g. of the formula (III), by oxidizing a thiourea, e.g. of the following formula (II): with H2O2 and a molybdenum catalyst to yield an aminoiminomethane sulfonic acid which can then be reacted with an amine followed by optional transamination steps.

专利号:US-4781866-A
优先权日:1985-03-15
标题 :Process for producing amidine sulfonic acid intermediates for guanidines
发明人:MARYANOFF CYNTHIA A; PLAMPIN JAMES N; STANZIONE ROBIN C
权利人:MCNEILAB INC
摘要:An efficient synthesis of quanidines, e.g. of the formula (III), by oxidizing a thiourea, e.g. of the following formula (II): with H2O2 and a molybdenum catalyst to yield an aminoiminomethane sulfonic acid which can then be reacted with an amine followed by optional transamination steps.

专利号:US-2012059163-A1
优先权日:2005-04-28
标题 :Non-linear opticaly active molecules, their synthesis, and use
发明人:MCGINNISS VINCENT D; RISSER STEVEN M; DROTLEFF ELIZABETH; JIANG EDWARD; SPAHR KEVIN B
权利人:MCGINNISS VINCENT D; RISSER STEVEN M; DROTLEFF ELIZABETH; JIANG EDWARD; SPAHR KEVIN B; OPTIMER PHOTONICS INC
摘要:In one aspect, the present invention provides a hyperpolarizable organic chromophore. The chromophore is a nonlinear optically active compound that includes a Ï€-donor conjugated to a Ï€-acceptor through a Ï€-electron conjugated bridge. In other aspects of the invention, donor structures and acceptor structures are provided. In another aspect of the invention, a chromophore-containing polymer is provided. In one embodiment, the chromophore is physically incorporated into the polymer to provide a composite. In another embodiment, the chromophore is covalently bonded to the polymer, either as a side chain polymer or through crosslinking into the polymer. In other aspects, the present invention also provides a method for making the chromophore, a method for making the chromophore-containing polymer, and methods for using the chromophore and chromophore-containing polymer.

专利号:US-4851094-A
优先权日:1985-03-15
标 题:Process for producing amidine sulfonic acid intermediates for guanidines
发明人:MARYANOFF CYNTHIA A; PLAMPIN JAMES N; STANZIONE ROBIN C
权利人:MCNEILAB INC
摘要:An efficient synthesis of quanidines, e.g. of the formula (III), by oxidizing a thiourea, e.g. of the following formula (II): (III) (II) with H2O2 and a molybdenum catalyst to yield an aminoiminomethane sulfonic acid which can then be reacted with an amine followed by optional transamination steps.
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合成参考文献


摘要:Podlech, J., Science of Synthesis Knowledge Updates, (2019) 1, 400.
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