溴甲苯,Hexadecyltributylphosphonium Thiocyanate置于水体系中,用 氘代苯 用作溶剂,化学反应生成硫氰酸苄酯,十六烷基三丁基溴化磷 参考文献:Ohtani,Noritaka; Murakawa,Shigeki; Watanabe,Kohji,Journal Of The Chemical Society. Perkin Transactions 2 (2001),2000,# 9,P. 1851-1856 标题:Ohtani,Noritaka; Murakawa,Shigeki; Watanabe,Kohji,Journal Of The Chemical Society. Perkin Transactions 2 (2001),2000,# 9,P. 1851-1856
专利号:US-2023286918-A1 优先权日:2020-07-02 标 题:Manufacturing process for 3,5-dichloropicolinonitrile for synthesis of vadadustat 发明人:JURKAUSKAS VALDAS; JUNG YOUNG CHUN; KWON TAESOO; KANNAN ARUNACHALAM; GONDI VIJAYA BHASKER 权利人:AKEBIA THERAPEUTICS INC 摘要:Disclosed herein are methods and processes of preparing vadadustat or a pharmaceutically acceptable salts thereof, and intermediates (e.g., a compound of Formula (I), (I-F), (II), or (IV), or a pharmaceutically acceptable salts thereof) useful for the synthesis of vadadustat.
专利号:US-9085538-B2 优先权日:2010-07-26 标题:Process for the preparation of key intermediates for the synthesis of statins or pharmaceutically acceptable salts thereof 发明人:CASAR ZDENKO; STERK DAMJAN; JUKIC MARKO 权利人:CASAR ZDENKO; STERK DAMJAN; JUKIC MARKO; LEK PHARMACEUTICALS 摘要:The invention relates to commercially viable process for the synthesis of key intermediates for the preparation of statins, in particular Rosuvastatin and Pitavastatin or respective pharmaceutically acceptable salts thereof. A new simple and short synthetic route for key intermediates is presented which benefits from the use of cheap and readily available starting materials, by which the conventionally most frequently used DIBAL-H as reducing agent can be avoided.
专利号:EP-0020401-B1 优先权日:1978-09-21 标 题 :Improved process for the synthesis of 1,4-diaza-2-cycloalkanone and substituted derivatives thereof 摘要:Improved process for the synthesis of 1,4-diaza-2-cycloalkanones and substituted derivatives thereof involving solid-liquid phase transfer phenomenon. More specifically, the subject compounds are prepared by combining a substituted diamine and suitable coreactant in the presence of a phase transfer catalyst and caustic.
专利号:US-4246412-A 优先权日:1979-08-27 标 题:Synthesis of 2-keto-1,4-diazacycloalkanes with a soft ion catalyst 发明人:LAI JOHN T 权利人:GOODRICH CO B F 摘要:A phase transfer catalyzed 'soft ion synthesis' is disclosed in which the presence of a 'soft ion' generated in situ by a soft ion catalyst has a directive effect which favors the formation of a polysubstituted 2-keto-1,4-diazacycloalkane isomer having substituents on both N4-adjacent carbon atoms ('C atoms') of its diaza ring; this isomer is formed at the expense of isomers in which an N4-adjacent C atom is not substituted. Such an isomer which has substituents on each N4-adjacent C atom is generally more effective as a u-v light stabilizer than an isomer which has an unsubstituted N4-adjacent C atom, and therefore the former is more desirable. A liquid phase reaction of an acyclic 1,2-diamine with a monoketone or monoaldehyde in the presence of a phase transfer catalyst, a haloform and alkali is disclosed, in which reaction a soft ion catalyst which generates a soft ion selected from the group consisting of cyanide, iodide and thiocyanate, has a directive effect on the reaction so as to produce more isomer with substituents on each N4-adjacent C atom than would be formed, under identical conditions but without the presence of the soft ion. The directive effect of the soft ion appears to enhance any directive effect that a particular phase transfer catalyst may exhibit.
专利号:US-4367346-A 优先权日:1981-04-23 标 题 :Method for synthesis of long-chain alcohols 发明人:PARKER DANE K 权利人:GOODYEAR TIRE & RUBBER 摘要:This invention is concerned with the preparation of long-chain carboxylic acids and alcohols from cyclododecanone and acyl chlorides. More specifically, this invention relates to a process for the preparation of 1-triacontanol, CH 3 (CH 2 ) 28 CH 2 OH. Triacontanol acts as a growth stimulant on a wide range of plants to increase dry weight gains, water uptake, water use efficiency and protein synthesis in treated plants.
专利号:US-2024308959-A1 优先权日:2021-06-29 标 题:Processes for the preparation of (s)-2-(4-chloro-2-methoxyphenyl)-2-((3 -methoxy-5-(m ethylsulfonyl)phenyl)amino)-1 -(1h-indol-3-yl)ethenone derivatives 发明人:WU KAI; OOST RIK; SCHWEITZER-CHAPUT BERTRAND; ERIKSSON CARL ARNE MAGNUS; COESEMANS ERWIN 权利人:JANSSEN PHARMACEUTICALS INC 摘要:The present invention relates to novel chiral synthesis of mono- or di-substituted indole compounds of formula (I) n n n n n n n n n n n n wherein: n R 1 is H, R 2 is F and R 3 is H or CH 3 , n R 1 is H, CH 3 or F, R 2 is OCH 3 and R 3 is H and n R 1 is H, R 2 is OCH 3 and R 3 is CH 3 , n R 1 is CH 3 , R 2 is F and R 3 is H, n R 1 is CF 3 or OCF 3 , R 2 is H and R 3 is H, n R 1 is OCF 3 , R 2 is OCH 3 and R 3 is H and n R 1 is OCF 3 , R 2 is H and R 3 is CH 3 .
摘要:Wicha, J., Science of Synthesis, (2009) 48, 185. 参考文献:10.1016/j.bmcl.2004.03.096|10.1016/s0960-894x(04)00470-6 摘要:Hill TA, Odell LR, Quan A, Abagyan R, Ferguson G, Robinson PJ, McCluskey A. Long chain amines and long chain ammonium salts as novel inhibitors of dynamin GTPase activity. Bioorganic & Medicinal Chemistry Letters. 2004 Jun;14(12):3275–8. doi: 10.1016/j.bmcl.2004.03.096.