CAS: 16063-80-2; 4,4,4,4',4',4'-Hexafluoro-Dl-Valine

相似化合物

1214705-90-4 1098184-03-2 107496-46-8

上下游产品

CAS号107496-45-7 DL-hexafluorova... | CAS号78185-92-9 2-氨基-4,4,4-三氟-3... | CAS号107496-44-6 benzyl β,β-bis(... | CAS号1513-60-6 4,4,4-三氟-3-三氟甲基丁酸乙酯 | CAS号78164-91-7 DL-hexafluorova... | CAS号759-25-1 Hexafluorisopro... | CAS号2711-61-7 2-Amino-2-hexaf... | CAS号1763-28-6 4,4,4-三氟-3-(三氟甲基)巴豆酸

4,4,4-三氟-3-三氟甲基丁酸乙酯置于盐酸,氨体系中,用 乙醚 用作溶剂,化学反应 10.67H,反应生成4,4,4,4',4',4'-六氟-Dl-缬氨酸
参考文献:含氟肽的合成.含有六氟缬氨酸的血管紧张素ii的类似物.
标题:含氟肽的合成.含有六氟缬氨酸的血管紧张素ii的类似物.
摘要:已经制备了γ,γ,γ,γ,六氟缬氨酸及其衍生物,并通过片段缩合和固相肽合成将其掺入血管紧张素ii中.六氟缬氨酸衍生物显示出对各种酶消化的一般抵抗力,并且在羧基活化后具有广泛消旋的趋势.当在大鼠子宫上测定血管紧张素ii类似物时,[hfv5] Aii具有133%的活性,[d-Hfv5] Aii没有活性,[ac-Asn1,Dl-Hfv8] Aii在体外是一种有效的血管紧张素ii抑制剂.体内.
Doi:10.1021/jm00141A005

专利信息

专利号:US-9206222-B2
优先权日:2009-06-29
标题:Solid phase peptide synthesis of peptide alcohols
发明人：CAUSSIL-AMBLARD MURIEL; MARTINEZ JEAN; TAILHADES JULIEN
权利人:CAUSSIL-AMBLARD MURIEL; MARTINEZ JEAN; TAILHADES JULIEN; CENTRE NAT RECH SCIENT
摘要:The present invention relates to the synthesis of depsipeptides on solid phase support. Said depsipeptides are then implicated in a solution phase O—N acyl shift enabling to obtain the corresponding peptide alcohols.

专利号:US-7371867-B2
优先权日:2001-02-27
标题 :Non-racemic trifluoroleucine, and methods of making and using
发明人：FICHERA ALFIO; BILGICER ZIHNI; KUMAR KRISHNA; XING XUECHAO
权利人:TUFTS COLLEGE
摘要:One aspect of the invention relates to hexafluoroleucine and congeners thereof, and methods of making the compounds. Another aspect of the invention relates to the synthesis of protein cores comprising hexafluoroleucine and congeners thereof. Certain peptides comprising hexafluoroleucine and congeners thereof have been characterized using comparative biophysical studies. In general, the fluorinated peptides show higher thermal stability and enhanced resistance to chemical denaturation. Further, mixed hydrocarbon-fluorocarbon cores self-sort into homogeneous bundles, suggesting new avenues for the design and manipulation of protein-protein interfaces.

专利号:US-8546533-B2
优先权日:2008-08-29
标 题:Pipecolic linker and its use for chemistry on solid support
发明人：MARTINEZ JEAN; ZAJDEL PAWEL; PAWLOWSKI MACIEJ; SUBRA GILLES
权利人:MARTINEZ JEAN; ZAJDEL PAWEL; PAWLOWSKI MACIEJ; SUBRA GILLES; CENTRE NAT RECH SCIENT; UNIV MONTPELLIER 1; UNIV JAGELLONE; UNIV MONTPELLIER II
摘要:The present invention relates to a pipecolic linker and its use as a solid-phase linker in organic synthesis. Said pipecolic solid-phase linker may be used for coupling functional groups chosen between primary amines, secondary amines, aromatic amines, alcohols, phenols and thiols. In particular, said pipecolic solid-phase linker may be used for peptide or pseudopeptide synthesis, such as the reverse N to C peptide synthesis or the retro-inverso peptide synthesis, or for the synthesis of small organic molecules.

专利号:WO-2011000848-A1
优先权日:2009-06-29
标题 :Solid phase peptide synthesis of peptide alcohols

专利号:US-11759496-B2
优先权日:2016-05-10
标题:Compounds and pharmaceutical use thereof in the treatment of cancer
发明人：SUSIN SANTOS A; KAROYAN PHILIPPE; MERLE-BERAL HÉLÈNE
权利人:KAROYAN PHILIPPE
摘要:The present invention relates to a compound or a pharmaceutical salt thereof comprising a hexapeptide sequence of formula (I), its method of synthesis and its use in anticancer therapy. The invention also relates to a pharmaceutical composition for use in the treatment of cancer comprising at least one soluble peptide according to the invention or at least one acid nucleic according to the invention or at least one expression vector according to the invention, or at least one host cell according to the invention and a pharmaceutically acceptable carrier.

专利号:US-2012108748-A1
优先权日:2009-06-29
标 题:Solid phase peptide synthesis of peptide alcohols