CAS: 1798-06-7; 2-(4-Iodophenyl)Acetic Acid

上下游产品

CAS号103-82-2 苯乙酸 | CAS号1197-55-3 对氨基苯乙酸 | CAS号51628-12-7 4-碘苯乙腈 | CAS号63349-52-0 2-(4-碘苯基)乙酸甲酯 | CAS号16004-15-2 对碘溴苄 | CAS号104-03-0 对硝基苯乙酸 | CAS号7664-93-9 硫酸 | CAS号7553-56-2 碘 | CAS号64-19-7 冰醋酸 | CAS号7697-37-2 硝酸 | CAS号62037-86-9 p-Trifluormethy... | CAS号32857-62-8 4-(三氟甲基)苯乙酸 | CAS号192804-72-1 methyl 2-[4-(4-... | CAS号21906-36-5 1-(4-碘苯基)丙-2-酮 | CAS号364794-81-0 4-(4-(4,4,5,5-四... | CAS号52914-23-5 4-碘苯乙醇 | CAS号350-62-9 (1,1-difluoro-2... | CAS号164931-20-8 methyl 2-[4-(4-... | CAS号163070-73-3 2-[2-(4-iodophe... | CAS号239783-48-3 6-碘-2-四氢萘酮

苯乙酸置于碘,硝酸,溶剂黄146体系中,化学反应生成4-碘苯乙酸
参考文献:Datta; Chatterjee,Journal Of The American Chemical Society,1919,Vol. 41,P. 295
标题:Datta; Chatterjee,Journal Of The American Chemical Society,1919,Vol. 41,P. 295

专利信息

专利号:US-7329515-B2
优先权日:2003-04-21
标题 :Solid support for the synthesis of 3′-amino oligonucleotides
发明人：LEUCK MICHAEL; WOLTER ANDREAS
权利人:SIGMA ALDRICH CO
摘要:The present invention discloses novel methods and solid supports for the synthesis of 3′-amino oligonucleotides. The novel supports are based on an unsubstituted or ring-substituted hydroxymethylbenzoyl linker element wherein the hydroxymethyl group is esterified to a solid phase bound carboxylic acid and the carbonyl group is linked to an amino alcohol as an amide. Oligonucleotides are conveniently synthesized on the novel supports with no modifications in the standard phosphoramidite synthesis scheme. The ester function of the support is cleaved under the alkaline deprotection conditions for oligonucleotides to provide a free hydroxymethyl group that aids in the release of the 3′-amino oligonucleotide products with a free amino group through neighbor group participation. The free amino group of the oligonucleotides is available for further conjugation reactions to haptens, reporter groups, surfaces or other small molecules or biomolecules. The methods provided are particularly mild, do not require any modifications in standard protocols for the synthesis and deprotection of oligonucleotides, provide the 3′-amino oligonucleotides free of side products and do not introduce chiral centers to the oligonucleotides.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:WO-2014138989-A1
优先权日:2013-03-15
标 题 :Method and intermediates for the synthesis of hydroxamic acid compounds
发明人：VAISBURG ARKADII; RAEPPEL FRANCK; ROY SIMON; ZHOU NANCY Z
权利人:METHYLGENE INC
摘要:Methods are disclosed for making a compound of formula and intermediates therefor, where R is aryl or heteroaryl, and L is C3_8alkylene, wherein each of R, L, and the illustrated phenyl group are independently optionally substituted with one or more substituents selected from the group consisting of C].6alkyl, Ci.6alkoxy, CF3, CHF2, CH2F, fluoro, and cyano, which methods can avoid the use of iodo-phenyl esters, or aryl alkynes, or both, or, in which synthetic methods at least one of the intermediates is a solid at room temperature that does not require purification by chromatography.

专利号:WO-2023137518-A1
优先权日:2022-01-21
标题 :Platinum complexes
发明人：ALDRICH-WRIGHT JANICE; GORDON CHRISTOPHER; DEO KRISHANT M; KHOURY ALEEN; MCGHIE BRONDWYN; APUTEN ANGELICO; PLATTEN-MENTI MARIA; RASHID FATIN; JURISINEC ASHLEY; SOLIMAN SARAH
权利人:WESTERN SYDNEY UNIV
摘要:The present disclosure relates to platinum complexes, and in particular platinum(II) and platinum(IV) complexes. The present disclosure also relates to synthesis of the platinum complexes, and to intermediates for the synthesis of the platinum complexes. The present disclosure also relates to methods and use of the platinum complexes for treating cancer.

专利号:US-2013261317-A1
优先权日:2010-09-27
标题 :Methods for preparing synthetic bile acids and compositions comprising the same
发明人：MORIARTY ROBERT M; RAO PHOTON
权利人:MORIARTY ROBERT M; RAO PHOTON; KYTHERA BIOPHARMACEUTICALS INC
摘要:This invention relates generally to methods for preparing certain bile acids from non-mammalian sourced starting materials as well as to synthetic bile acids and compositions comprising such acids wherein the acids are characterized by a different C 14 population than naturally occurring bile acids as well as being free from any mammalian pathogens. This invention is also directed to the synthesis of intermediates useful in the synthesis of such bile acids. Accordingly, the C ring of the steroidal scaffold is oxidized to provide a synthetic route and intermediates to DCA. This invention also provides synthetic methods for preparing deoxycholic acid or a salt thereof starting from aromatic steroids such as estrogen, equilenin, and derivatives thereof. This invention is also directed to intermediates such as 12-oxo or delta-9,11-ene steroids as well as novel processes for their preparation. In preferred embodiments, bile acids are provided herein which have substituents on the B-ring and/or D-ring side chain and optionally on the hydroxy group of the A-ring.

专利号:US-2004220397-A1
优先权日:2003-04-21
标题:Solid support for the synthesis of 3'-amino oligonucleotides