CAS: 18355-80-1; 1-(2,3-Difluorophenyl)Ethanone

该化合物是一种含分子式C8H6F2O的氟芳香酮.该化合物是有机合成中有价值的中间体,特别是在制药,农用化学品和特殊化学品的制备方面.其二氟苯基混合物可增强活性和稳定性,使其适合在受控制条件下选择性地发挥功能.该氯酮组为进一步衍生提供了多种操作器,包括减排,核生殖添加或凝聚.高纯度能确保敏感反应的性能一致.其结构特征有助于提高药物开发应用的生物利用率和代谢稳定性.该化合物一般供应的清晰度为浅黄色液体或低熔化固体,并有严格的质量控制以满足研究和工业要求.

结构式图片

欧盟法规

ECHA物质C&L通报

上下游产品

1-(2,3-二氟苯基)乙醇 (+/-)-1-(2,3-Difluorophenyl)Ethanol 1228690-56-9

合成工艺路线路线简述

    苯乙酮 反应生成2,3-二氟苯乙酮
    参考文献:Sopher,David William;Meurs,Jan Hermen Hendrik
    标题:Sopher,David William;Meurs,Jan Hermen Hendrik

    海关参考信息

    专利信息


    专利号:US-6217901-B1
    优先权日:1999-05-25
    标题:Liposome-assisted synthesis of polymeric nanoparticles
    发明人:PERROTT MICHAEL G; BARRY STEPHEN E
    权利人:ALNIS LLC
    摘要:Synthetic polymer complements (SPCs) are provided, as well as methods for their synthesis and use. The SPCs range in size from about 20 to about 1000 nm. The SPCs have surfaces that are complementary to surface sites of target molecules, resulting in the ability of the SPCs to selectively bind to molecular targets. The molecular recognition capability of these particles enables their use in diagnostic, therapeutic, and separation applications. The SPC is formed by contacting a target template molecule with a set of building blocks solubilized in the interior of a liposome, which building blocks are then polymerized into a network to form the synthetic polymer complement in the interior of the liposome. The target templates are removed to produce complementary sites in a SPC that map the surface of the target, resulting in a water-soluble SPC nanoparticle of similar dimensions as the interior of the liposome that originally supported it and capable of molecular recognition.

    专利号:US-5605970-A
    优先权日:1996-03-20
    标 题 :Synthesis of high molecular weight anionic dispersion polymers
    发明人:SELVARAJAN RADHAKRISHNAN
    权利人:NALCO CHEMICAL CO
    摘要:A process for synthesizing high molecular weight anionic dispersion polymer is disclosed, the process comprising providing a mixture of water, acrylic acid and a stabilizer; cooling the mixture to a temperature of less than 35 DEG C.; lowering the pH of the mixture to less than 4.5; adding ethylhexyl acrylate to the mixture to form an aqueous solution; stirring the aqueous solution; purging the solution with nitrogen simultaneous with the step of stirring; heating the solution to about 48 DEG C.; adding initiator for from about 2 to about 3 hours; heating the solution to about 75 DEG C. for about 30 to about 60 minutes; and cooling and collecting the polymer.

    专利号:US-11116810-B2
    优先权日:2012-10-26
    标 题 :Methods for treatment of skin and skin appendages with a linseed extract as an active agent activating the synthesis of antimicrobial peptides
    发明人:BOTTO JEAN-MARIE; DOMLOGE NOUHA; PORTOLAN FREDERIQUE
    权利人:ISP INVESTMENTS INC; ISP INVESTMENTS LLC
    摘要:Methods for the treatment of irritations of the skin and skin appendages caused by microbial stresses are disclosed. The methods include providing a composition comprising a linseed extract, obtained from hydrolysis of linseed proteins, as an active antimicrobial agent in a physiologically acceptable medium, and topically applying the linseed extract onto the skin in need thereof. The methods may be useful in the cosmetic and pharmaceutical field and, more particularly, in the field of dermatology. Cosmetic methods for reinforcing the chemical barrier function of healthy and/or sensitive skin and skin appendages are also disclosed that include the same or similar composition and steps.

    专利号:US-7754455-B2
    优先权日:2004-03-19
    标题:Biocatalytic manufacturing of (meth) acrylylcholine or 2-(N, N-dimethylamino) ethyl (meth) acrylate
    发明人:HUGHES JONATHAN; SYMES KENNETH CHARLES
    权利人:CIBA SPEC CHEM WATER TREAT LTD
    摘要:A biocatalytic method for the synthesis of 2-(N,N-dimethyl amino)ethanol and/or choline esters of acrylic acid and/or methacrylic acid comprising reacting 2-(N,N-dimethylamino)ethanol and/or choline with acrylyl-CoA and/or methacrylyl-coA in the presence of a biocatalyst with choline acetyltransferase activity. The acrylyl-CoA and/or the methacrylyl CoA is formed by the reaction of acrylate and/or methacrylate with coenzyme A in the presence of ATP and a biocatalyst with S-acetyl coenzyme A synthetase activity.

    专利号:US-2016130208-A1
    优先权日:2013-06-11
    标题:Synthesis of alpha,beta-unsaturated carboxylic acid (meth)acrylates from olefins and co2
    发明人:SCHÄFFNER BENJAMIN; BLUG MATTHIAS; VOGT DIETER; HENDRIKSEN COEN; PIDKO EVGENY
    权利人:EVONIK DEGUSSA GMBH
    摘要:The invention relates to a method for producing α,β-unsaturated carboxylic acids or salts thereof, comprising a step in which a metallalactone is reacted in a solvent in the presence of a halide; to a composition that comprises α,β-unsaturated carboxylic acids or salts thereof and halide ions; and to the use of said composition for the production of superabsorbent materials or as a monomer composition for producing polymers.

    专利号:US-7524354-B2
    优先权日:2005-07-07
    标 题:Controlled synthesis of highly monodispersed gold nanoparticles
    发明人:ZHONG CHUAN-JIAN; NJOKI PETER N; LUO JIN
    权利人:UNIV NEW YORK STATE RES FOUND
    摘要:A method of synthesizing highly monodispersed Au nanoparticles having diameters in the range of 30-90 nm. Seed nanoparticles in a controlled concentration are combined with a precursor, also in a controlled concentration, a reducing and capping agent (e.g., sodium acrylate) in aqueous solution. Under controlled conditions of pH, temperature, and time, highly monodispersed nanoparticles having diameters in the range of 30-100 nm are produced. A relative size standard deviation of the size distribution of the resulting nanoparticles is as low as 2%.
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    合成参考文献


    摘要:Stoltz, B. M.; Wright, A. C.; Ebner, D. C.; Park, N., Science of Synthesis: Catalytic Oxidation in Organic Synthesis, (2017) 1, 580.
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