CAS: 19788-37-5; 4-(Chloromethyl)-3,5-Dimethylisoxazole

相似化合物

31301-45-8 40500-39-8 104988-43-4

上下游产品

CAS号300-87-8 3,5-二甲基异唑 | CAS号50-00-0 甲醛 | CAS号19788-36-4 3,5-二甲基-4-羟甲基异噁唑 | CAS号28241-32-9 (3,5-dimethyl-1... | CAS号28458-37-9 4-[2-(3,4-dihyd... | CAS号131052-47-6 (3,5-二甲基异恶唑-4-基)甲胺 | CAS号19788-36-4 3,5-二甲基-4-羟甲基异噁唑 | CAS号2510-36-3 3,5-二甲基异噁唑-4-羧酸 | CAS号10557-82-1 3,4,5-trimethyl... | CAS号85679-16-9 3-Penten-2-one,... | CAS号75632-85-8 4-[2-(3,5-dimet... | CAS号75632-86-9 3,5-dimethyl-4-... | CAS号39962-28-2 2-[(3,5-dimethy...

3,5-二甲基异唑置于盐酸,氯化亚砜体系中,用 二氯甲烷 用作溶剂,化学反应 1.5H,反应生成4-氯甲基-3,5-二甲基异噁唑
参考文献:巯基甲基异恶唑衍生的新型三唑抗真菌剂
标题:巯基甲基异恶唑衍生的新型三唑抗真菌剂
摘要:衍生自具有一般结构2(2,4-二卤代苯基)-3-((x-异恶唑基)甲硫基)-(1,2,4-三唑-1-基)-2-丙醇的巯基甲基异恶唑的几种新型三唑抗真菌剂以及一些衍生的亚砜和砜已经合成并测试了抗真菌活性.这些化合物中的一些对酵母和皮肤真菌显示出非常好的活性.
Doi:10.1002/jhet.5570290631

专利信息

专利号:US-4080334-A
优先权日:1968-11-22
标题:Intermediates in the total synthesis employing substituted isoxazole derivatives
发明人：SAUCY GABRIEL; SCOTT JOHN WILLIAM
权利人:HOFFMANN LA ROCHE
摘要:The intermediates and processes of this invention provide a new synthetic route for the preparation of pharmaceutically valuable 19-norsteroids. Further, the intermediates and processes of the invention provide a route for the preparation of pharmaceutically valuable estrones. The present invention provides a facile total synthesis of 19β-alkyl-C/D-trans-steroidal materials. This desirable result is obtained via a unique asymmetric induction followed by subsequent stereo-specific reaction steps. As a precursor to the steroidal Ring A, a 3,5-disubstituted-4-isoxazolylmethylene group is employed in this synthesis.

专利号:US-3985771-A
优先权日:1968-11-22
标题:Total steroid synthesis employing substituted isoxazole derivatives
发明人：SAUCY GABRIEL; SCOTT JOHN WILLIAM
权利人:HOFFMANN LA ROCHE
摘要:The novel intermediates and processes of this invention provide a new synthetic route for the preparation of pharmaceutically valuable 19-nor-steroids. Further, the intermediates and processes of the invention provide a novel route for the preparation of pharmaceutically valuable estrones. The present invention provides a facile total synthesis of 13β-alkyl-C/D-trans-steroidal materials. This desirable result is obtained via a unique asymmetric induction followed by subsequent stereo-specific reaction steps. As a precursor to the steroidal Ring A, a 3,5-disubstituted-4-isoxazolylmethylene group is employed in this synthesis.

专利号:US-4044004-A
优先权日:1968-11-22
标题 :Total steroid synthesis employing substituted isoxazole derivatives
发明人：SAUCY GABRIEL; SCOTT JOHN WILLIAM
权利人:HOFFMANN LA ROCHE
摘要:The novel intermediates and processes of this invention provide a new synthetic route for the preparation of pharmaceutically valuable 19-norsteroids. Further, the intermediates and processes of the invention provide a novel route for the preparation of pharmaceutically valuable estrones. The present invention provides a facile total synthesis of 19β-alkyl-C/D-trans-steroidal materials. This desirable result is obtained via a unique asymmetric induction followed by subsequent stereospecific reaction steps. As a precursor to the steroidal Ring A, a 3,5-disubstituted-4-isoxazolylmethylene group is employed in this synthesis.

专利号:US-9936723-B2
优先权日:2014-02-12
标题 :Process for the synthesis of substituted 1-benzyl-3-(1-(isoxazol-4-ylmethyl)-1h-pyrazol-4-yl)imidazolidine-2,4-diones
发明人：FOTSING JOSEPH R
权利人:SENOMYX INC
摘要:The present invention relates to processes and intermediates for the preparation of compounds of formula (I): n nor a salt or oxide thereof, wherein Alk, M1, M2, R1, R2, R3, R4, R5, R6, R7, and n are as described herein. The present invention also relates to compounds of formula (I) and composition comprising a compound of formula (I). Also disclosed is a method of altering or improving the taste of a composition that includes adding to the composition at least one compound of formula (I), in an amount effective to obtain a modified composition having altered or improved taste relative to an otherwise identical composition lacking said compound.

专利号:US-3984427-A
优先权日:1968-11-22
标 题:Preparation of vinyl lactones and corresponding Mannich bases
发明人：SAUCY GABRIEL
权利人:HOFFMANN LA ROCHE
摘要:Vinyl ketones and Mannich-bases obtained therefrom are useful as intermediates in the total synthesis of steroids having valuable pharmacological properties. These compounds are prepared by the low temperature reaction of a vinyl Grignard e.g., vinyl magnesium chloride with substituted γ, δ or ε lactones followed, if desired, by reaction of the vinyl ketone obtained with a primary or secondary amine. Particular compounds prepared by this procedure include 2-(2-substituted aminoethyl)-6-substituted-2-hydroxy-tetrahydropyrans and the tautomers thereof.

专利号:US-3838163-A
优先权日:1968-11-22
标题 :Substituted isoxazole derivatives as steroid intermediates
发明人：SAUCY G; SCOTT J
权利人:HOFFMANN LA ROCHE
摘要:THE NOVEL INTERMEDICATES AND PROCESSES OF THIS INVENTION PROVIDES A NEW SYNTHETIC ROUTE FOR THE PREPARATION OF PHARMACEUTICALLY VALUABLE19-NOR-STEROIDS. FURTHER, THE INTERMEDICATES AND PROCESSES OF THE INVENTION PROVIDE A NOVEL ROUTE FOR THE PREPARATION OF PHARMACEUTICALLY VALUABLE ESTRONES. THE PRESENT INVENTION PROVIDES A FACILE TOTAL SYNTHESIS OF 13B-ALKYL-C D-TRANS-STEROIDAL MATERIALS. THE DESIRABLE RESULT IS OBTAINED VIA A UNIQUE ASYMMETRIC INDUCTION FOLLOWED BY SUBSEQUENT STEREO-SPECIFIC REACTION STEPS. AS APRECURSOR TO THE SUBSEQUENT STEREOIDAL RING A, A 3,5-DISUBSTI 4-ISOXAZOLYLMETHYLENE GROUO IS EMPLOYED IN THIS SYNTHESIS.