专利号:US-10253153-B2 优先权日:2015-04-24 标题 :Linker and support for solid phase synthesis of nucleic acid, and production method of nucleic acid using said support 发明人:MAETA ERI; MORI KENJIRO; HORIE SHOHEI; ITO TAKAHIKO; SAITO SHOICHIRO; NAGAO RYUHEI 权利人:NITTO DENKO CORP 摘要:The present invention provides a linker for solid phase synthesis of nucleic acid, which consists of a compound represented by the formula (I) or the formula (II), a support for solid phase synthesis of nucleic acid, which has a structure represented by the formula (III), and a production method of a nucleic acid, which uses the support: n nwherein each symbol is as defined in the SPECIFICATION.
专利号:US-8729277-B2 优先权日:2009-04-06 标 题:Processes for the synthesis of gamma nitrocarbonyl and gamma dicarbonyl compounds and their pyrrole derivatives 发明人:YANG HU; BARALT EDUARDO J 权利人:YANG HU; BARALT EDUARDO J; CHEVRON PHILLIPS CHEMICAL CO 摘要:The present invention discloses processes for producing γ-nitrocarbonyl and γ-dicarbonyl compounds, which can be precursors in the synthesis of pyrrole compounds. A process for producing pyrroles such as 2,5-dimethylpyrrole, and structurally similar pyrrole compounds, is also disclosed.
专利号:US-4894385-A 优先权日:1985-01-16 标 题:Imidazole derivatives as inhibitors of TXA2 synthesis 发明人:KAWAMOTO ISAO; ENDO ROKURO; MATSUDA KEIICHI; USHIYAMA SHIGERU; OSHIMA TAKESHI 权利人:SANKYO CO 摘要:Compounds of formula (I): ##STR1## (wherein n is 0, 1 or 2 and R 1 , R 2 , R 4 , R 5 , R 6 , X, Y and Z are a variety of groups and atoms) have the ability to inhibit the synthesis of thromboxane A 2 and hence are useful in the treatment or prophylaxis of thrombotic conditions.
专利号:US-7078574-B2 优先权日:2001-04-21 标题 :Method for the intrinsically safe handling of 3-chloropropyne 发明人:STAMM ARMIN; KNEUPER HEINZ-JOSEF; RITTINGER STEFAN; DRANSFELD PETER; SCHILDBERG HANS-PETER; HEILIG MANFRED; WEBER THEODOR 权利人:BASF AG 摘要:A method is provided for the intrinsically safe handling of 3-chloropropyne in the presence of a diluent with a boiling point ranging from −50° C. (223 K) to 200° C. (473 K) under atmospheric pressure, wherein the concentration of 3-chloropropyne in the liquid phase and in the gas phase is kept below the concentrations capable of deflagration by means of the type and amount of the diluent, the temperature and the total system pressure, together with the use of a 3-chloropropyne prepared, stored or transported in this way in the synthesis of dyestuffs, pharmaceutical and agricultural active ingredients, electroplating auxiliaries, disinfectants, steroids and growth hormones.
专利号:US-7320993-B1 优先权日:1997-12-17 标题 :Aryl-substituted pyridylalkane, alkene, and alkine carboxamides useful as cytostatic useful as cytostatic and immuosuppressive agents 发明人:BIEDERMANN ELFI; HASMANN MAX; LOESER ROLAND; RATTEL BENNO; REITER FRIEDEMANN; SCHEIN BARBARA; SEIBEL KLAUS; VOGT KLAUS; WOSIKOWSKI KATJA; SCHEMAINDA ISABEL 权利人:ASTELLAS DEUTSCHLAND GMBH 摘要:The invention relates to new pyridylalkane, alkene, and alkine acid amides substituted with an aryl and/or heteroaryl residue according to the general formula (I), with a saturated or one or several-fold unsaturated hydrocarbon residue in the carboxylic acid group, methods for the synthesis of these compounds, medicaments containing these and their production as well as their therapeutic use, especially as cytostatic agents and immunosuppressive agents, for example in the treatment or prevention of various types of tumors and control of immune reactions such as autoimmune diseases.
专利号:US-7375058-B2 优先权日:2001-09-14 标 题:Herbicidal mixtures based on 3-phenyluracils 发明人:ZAGAR CYRILL; SIEVERNICH BERND; QUAKENBUSH LAURA; EVANS RICHARD R; LANDES MAX; NEWSOM LARRY J; ORTLIP CHARLES L; WITSCHEL MATTHIAS; LANDES ANDREAS 权利人:BASF AG 摘要:Herbidically active compositions, comprising: A) at least one phenyluracil compound of the formula (I); in which the variables R 1 -R 7 are as defined in the claims, and/or at least one of its agriculturally acceptable salts; and at least one further active compound, selected from B) herbicides of classes b1) to b15): b1) lipid biosynthesis inhibitors; b2) acetolactate synthase inhibitors (ALS inhibitors); b3) photosynthesis inhibitors; b4) protoporphyrinogen-IX oxidase inhibitors; b5) bleacher herbicides; b6) enolpyruvyl shikimate 3-phosphate synthase inhibitors (EPSP inhibitors); b7) glutamine synthetase inhibitors; b8) 7,8-dihydropteroate synthase inhibitors (DHP inhibitors); b9) mitose inhibitors; b10) inhibitors of the synthesis of very long chain fatty acids (VLCFA inhibitors); b11) cellulose biosynthesis inhibitors; b12) decoupler herbicides; b13) auxin herbicides; b14) auxin transport inhibitors; b15) other herbicides selected from the group consisting of benzoylprop, flamprop, flamprop-M, bromobutide, chlorflurenol, cinmethylin, methyldymron, etobenzanid, fosamine, metam, pyributicarb, oxaziclomefone, dazomet, triaziflam and methyl bromide; and safeners selected from: benoxacor, cloquintocet, cyometrinil, dichlormid, dicyclonon, dietholate, fenchlorazole, fenclorim, flurazole, fluxofenim, furilazole, isoxadifen, mefenpyr, mephenate, naplithalic anhydride, 2,2,5-trimethyl-3-(dichloroacetyl)-1,3-oxazolidine, 4-(dichloroacetyl)-1-oxa-4-azaspiro[4.5]decane and oxabetrinil, the agriculturally acceptable salts of the active compounds B and C and the agriculturally acceptable derivatives of the active compounds B and C, provided they have a carboxyl group
[参考文献]: F B Hopkins, Et Al. Chemical Analysis Of Bleach And Hydroxide-Based Solutions After Decontamination Of The Chemical Warfare Agent O-Ethyl S-2-Diisopropylaminoethyl Methylphosphonothiolate (Vx). Anal Bioanal Chem. 2014 Aug;406(21):5111-9.
合成参考文献
摘要:Bertus, P.; Boeda, F.; Pearson-Long, M. S. M., Science of Synthesis Knowledge Updates, (2012) 1, 24. 摘要:Podlech, J., Science of Synthesis Knowledge Updates, (2018) 4, 187. 摘要:Podlech, J., Science of Synthesis Knowledge Updates, (2018) 4, 136. 摘要:Khandelia, T.; Ghosh, S.; Patel, B. K., Science of Synthesis: Cross-Dehydrogenative Coupling, (2023) nan, 177.