CAS: 301673-14-3; Tert-Butyl 4-Iodopiperidine-1-Carboxylate

相似化合物

885275-00-3 1353979-67-5 75844-69-8

上下游产品

CAS号109384-19-2 N-B°C-4-羟基哌啶 | CAS号288-32-4 咪唑 | CAS号84358-13-4 1-B°C-4-哌啶甲酸 | CAS号5382-16-1 4-羟基哌啶 | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号1086398-00-6 1-B°C-4-(3-FLUO... | CAS号206446-49-3 3',4',5',6'-四氢-... | CAS号828243-30-7 1-B°C-4-(3-羧基-苯基)-哌啶 | CAS号123387-49-5 4-苯基-1-哌啶羧酸叔丁酯 | CAS号170838-26-3 1-B°C-4-(2-羧基苯基)哌啶 | CAS号170011-56-0 4-(4-硝基苯基)哌啶-1-羧酸叔丁酯 | CAS号149353-75-3 1-B°C-4-(4'-羧基苯基)哌啶 | CAS号193217-39-9 4-苯甲酰哌啶-1-羧酸叔丁酯 | CAS号162997-34-4 4-(哌啶-4-基)苯甲腈盐酸盐 | CAS号1160592-00-6 4-丁基哌啶-1-羧酸叔丁酯

1-Boc-4-哌啶甲酸置于1,3-二碘-5,5-二甲基海因体系中,用 1,2-二氯乙烷 作为反应溶剂,化学反应 2.0H,以80%的收率获得产物n-Boc-4-碘哌啶
参考文献:具有可生物降解副产物的无金属高效,通用和简便的碘脱羧方法
标题:具有可生物降解副产物的无金属高效,通用和简便的碘脱羧方法
摘要:据报道,在不使用重金属或强氧化剂的情况下,将脂肪族和芳香族羧酸一般转化为有机碘化物的新颖,有效和鲁棒的方法的开发.在辐照条件下,可商购获得的n-碘酰胺既用于引发反应,又用于卤素的捐赠.产品的分离非常简单,主要副产物作为水溶性生物可降解材料被去除.
DOI:10.1002/adsc.201100145

专利信息

专利号:US-10226449-B2
优先权日:2013-12-20
标 题:Heterocyclic modulators of lipid synthesis and combinations thereof
发明人：HEUER TIMOTHY SEAN; OSLOB JOHAN D; MCDOWELL ROBERT S; JOHNSON RUSSELL; YANG HANBIAO; EVANCHIK MARC; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W; DUKE GREGORY; OHOL-GUPTA YAMINI; O'FARRELL MARIE
权利人:3 V BIOSCIENCES INC
摘要:Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by dysregulation of a fatty acid synthase pathway by the administration of such compounds and combinations of such compounds and other therapeutic agents.

专利号:US-9428502-B2
优先权日:2012-07-03
标题:Heterocyclic modulators of lipid synthesis
发明人：OSLOB JOHAN D; MCDOWELL ROBERT S; JOHNSON RUSSELL; YANG HANBIAO; EVANCHIK MARC; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W; WAGMAN ALLAN S
权利人:3-V BIOSCIENCES INC
摘要:Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by disregulation of a fatty acid synthase pathway by the administration of such compounds.

专利号:WO-2023086799-A1
优先权日:2021-11-09
标 题:Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists
发明人：HOUZE JONATHAN B; PANDYA BHAUMIK; KAPLAN ALAN P
权利人:VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 ('TREM2'). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

专利号:WO-2010096722-A1
优先权日:2009-02-20
标 题 :3-oxo-2, 3-dihydro- [1,2, 4] triazolo [4, 3-a]pyridines as soluble epoxide hydrolase (seh) inhibitors
发明人：FENG JUN; KEUNG WALTER; NOTZ WOLFGANG REINHARD LUDWIG
权利人:TAKEDA PHARMACEUTICAL; FENG JUN; KEUNG WALTER; NOTZ WOLFGANG REINHARD LUDWIG
摘要:Claimed are intermediates in the synthesis of N-Arylmethyl-3-Oxo-2,3-dihydro- [1,2,4]triazolo[4,3-a]pyridine-6-carboxamides as well as a process (A) to arrive at 3-Oxo-2, 3-dihydro-[1,2,4]triazolo[4,3-a]pyridine-6-carboxylic acid. The triazolo[4,3-a]pyridine-6-carboxamides of formula (I) are used as soluble epoxide hydrolase inhibitors (sEH) having therapeutic effect in pathologic conditions such as hypertension, stroke, inflammatory processes, diabetes and a variety of cardiovascular diseases.

专利号:US-9708336-B2
优先权日:2014-01-22
标题 :Metallo-beta-lactamase inhibitors
发明人：MANDAL MIHIR; TANG HAIFENG; XIAO LI; SU JING; LI GUOQING; YANG SHU-WEI; PAN WEIDONG; TANG HAIQUN; DEJESUS REYNALDA; HICKS JACQUELINE; LOMBARDO MATTHEW; CHU HONG; HAGMANN WILLIAM; PASTERNAK ALEX; GU XIN; JIANG JINLONG; DONG SHUZHI; DING FA-XIANG; LONDON CLARE; BISWAS DIPSHIKHA; YOUNG KATHERINE; HUNTER DAVID N; ZHAO ZHIQIANG; YANG DEXI
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.

专利号:CN-116332711-A
优先权日:2023-03-29
标题:Application of a Bilateral Disulfide Reagent in Step-by-Step Synthesis of Unsymmetrical Disulfides