CAS: 3107-34-4; 2-(Trifluoromethyl)Phenylhydrazine Hydrochloride

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CAS号115171-06-7 di-tert-butyl 1... | CAS号395-47-1 (2-(trifluorome...

邻氨基三氟甲苯置于盐酸,Sodium Nitrite,Sodium Hydrogensulfite体系中,用 水 用作溶剂,化学反应 3.5H,反应生成2-(三氟甲基)苯肼盐酸盐
参考文献:Design,Synthesis And Pharmacological Evaluation Of 6,7-Disubstituted-4-Phenoxyquinoline Derivatives As Potential Antitumor Agents
标题:Design,Synthesis And Pharmacological Evaluation Of 6,7-Disubstituted-4-Phenoxyquinoline Derivatives As Potential Antitumor Agents
摘要:Two Series Of 6,7-Disubstituted-4-Phenoxyquinoline Derivatives Bearing 2,4-Imidazolinedione/pyrazolone Scaffold Were Designed,Synthesized And Evaluated For Their C-Met Kinase Inhibition And Cytotoxicity Against Ht-29,H460,A549,Mkn-45,And U87Mg Cancer Cell Lines In Vitro. The Pharmacological Data Indicated That Most Of The Tested Compounds Showed Moderate To Significant Cytotoxicity And High Selectivity Against Ht-29,H460 And A549 Cancer Cell Lines As Compared With Foretinib. The Sar Analyses Indicated That Compounds With Halogen Groups,Especially Trifluoromethyl Groups At 2-Position On The Phenyl Ring (Moiety B) Were More Effective. In This Study,A Promising Compound 17 (C-Met Ic50 = 2.20 Nm,A Multi-Target Tyrosine Kinase Inhibitor) Showed The Most Potent Antitumor Activities With Ic50 Values Of 0.14 Mu M,0.18 Mu M,0.09 Mu M,0.03 Mu M,And 1.06 Mu M Against Ht-29,H460,A549,Mkn-45,And U87Mg Cell Lines,Respectively. (C) 2014 Elsevier Inc. All Rights Reserved.
Doi:10.1016/j.Bioorg.2014.07.011

专利信息

专利号:US-11040938-B2
优先权日:2016-07-27
标 题 :Continuous flow process for the synthesis of phenylhydrazine salts and substituted phenylhydrazine salts
发明人：MA BING; PAN SHUAI
权利人:SHANGHAI HYBRID—CHEM TECH; SHANGHAI HYBRID CHEM TECH
摘要:The present invention provided a continuous flow process for the synthesis of phenylhydrazine salts and substituted phenylhydrazine salts. Diazotization, reduction, acidic hydrolysis and salifying with acids are innovatively integrated together. Using acidic liquids of aniline or substituted aniline, diazotization reagents, reductants and acids as raw materials, phenylhydrazine derivative salts is obtained through the synthesis process, which is a three-step continuous tandem reaction including diazotization, reduction, acidic hydrolysis and salifying. The described synthesis process is a kind of integrated solutions, which is carried out in an integrated reactor. The feed inlets of the integrated reactor are continuously filled with raw materials. In the integrated reactor, diazotization, reduction, acidic hydrolysis and salifying are carried out continuously and orderly, and phenylhydrazine salts or substituted phenylhydrazine salts is obtained in the outlet of the integrated reactor without interruption. The total reaction time is no more than 20 min.

专利号:US-2019152896-A1
优先权日:2016-07-27
标题 :Continuous Flow Process For the Synthesis of Phenylhydrazine Salts and Substituted Phenylhydrazine Salts

专利号:US-8030311-B2
优先权日:2005-04-14
标题:Phenylacetamides suitable as protein kinase inhibitors
发明人：BOLD GUIDO; FURET PASCAL; GUAGNANO VITO; MCCARTHY CLIVE; VAUPEL ANDREA
权利人:NOVARTIS AG
摘要:The invention relates to compounds of the formula (I) wherein the moieties R1, R2, R3, R9, R10 and Q and X, Y and Z are as defined in the specification, and salts thereof, as well as their use, methods of use for them and method of their synthesis, and the like. The compounds are protein kinase inhibitors and can, inter alia, be used in the treatment of various proliferative diseases.

专利号:CN-107663161-B
优先权日:2016-07-27
标题:A kind of continuous flow synthesis process of phenylhydrazine salt and substituted phenylhydrazine salt

专利号:CN-107663161-A
优先权日:2016-07-27
标 题 :A kind of continuous flow synthesis process of phenylhydrazine salt and substituted phenylhydrazine salt