CAS: 3162-96-7; (4Ar,6S,7R,8R,8As)-6-Methoxy-2-Phenylhexahydropyrano[3,2-D][1,3]Dioxine-7,8-Diol

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上下游产品

CAS号1125-88-8 苯甲醛二甲缩醛 | CAS号97-30-3 甲基葡萄糖苷 | CAS号100-52-7 苯甲醛 | CAS号617-86-7 三乙基硅烷 | CAS号148406-80-8 methyl (2S,4R)-... | CAS号64552-05-2 (2R,4aR,6S,7R,8... | CAS号7177-79-9 methyl 2,3-di-O... | CAS号774-48-1 苯甲醛二乙缩醛 | CAS号2641-79-4 甲基2,3,4,6-四-O-(... | CAS号67-56-1 甲醇 | CAS号106220-89-7 Methyl2,3-di-O-... | CAS号97-30-3 甲基葡萄糖苷 | CAS号4141-38-2 1,3-Dioxolane,2... | CAS号604-70-6 2,3,4,6-四-o-乙酰基... | CAS号81712-57-4 methyl 4,6-O-be... | CAS号983-79-9 Benzophenone, azine | CAS号28642-64-0 2-O-苄基-4,6-二-O-... | CAS号33535-04-5 METHYL-3-O-BENZ... | CAS号6748-85-2 Methyl-4,6-di-O...

A-无水葡萄糖酯置于d(+)-10-樟脑磺酸,乙酰氯体系中,用 乙腈 用作溶剂,化学反应 144.0H,反应生成甲基-4,6-O-亚苄基-α-D-吡喃葡糖苷
参考文献:D-和 L-葡萄糖多磷酸盐模拟 D-肌醇 1,4,5-三磷酸:Ins(1,4,5)P3 受体的新型合成激动剂和部分激动剂.
标题:D-和 L-葡萄糖多磷酸盐模拟 D-肌醇 1,4,5-三磷酸:Ins(1,4,5)P3 受体的新型合成激动剂和部分激动剂.
摘要:手性糖衍生物是 Ca2+ 动员细胞内信使 D-肌醇 1,4,5-三磷酸 [ins(1,4,5)P3] 的潜在环醇替代物.合成了来自 D-和 L-葡萄糖的六种新型多磷酸化类似物.研究了与 Ins(1,4,5)P3 受体 [ins(1,4,5)P3R] 的结合以及通过 1 型 Ins(1,4,5)P3Rs 从细胞内储存释放 Ca2+ 的能力.β-D-吡喃葡萄糖基 1,3,4-Tris-磷酸盐,具有与 Ins(1,4,5)P3 相似的磷酸盐区域化学和立体化学,α-D-吡喃葡萄糖基 1,3,4-Tris-磷酸盐是完全激动剂,在 Ca2+ 释放试验中与 Ins(1,4,5)P3 等效,分别比 Ins(1,4,5)P3 弱 23 倍,与 Ins(1,4,5)P3 相似,在结合测定中弱 15 倍.它们可以被视为腺磷蛋白 A 的截短类似物,并加深对这种 Ins(1,4,5)P3R 激动剂结构-活性关系的理
Doi:10.1021/acs.Jmedchem.0C00215

专利信息

专利号:US-9260371-B2
优先权日:2004-11-01
标题:Compositions and methods for modification of biomolecules
发明人：BERTOZZI CAROLYN RUTH; AGARD NICHOLAS J; PRESCHER JENNIFER A; BASKIN JEREMY MICHAEL; SLETTEN ELLEN MAY
权利人:UNIV CALIFORNIA
摘要:The present invention provides modified cycloalkyne compounds; and method of use of such compounds in modifying biomolecules. The present invention features a cycloaddition reaction that can be carried out under physiological conditions. In general, the invention involves reacting a modified cycloalkyne with an azide moiety on a target biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provide for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).

专利号:US-2018118884-A1
优先权日:2015-04-13
标 题 :Use of co2 for the synthesis of cyclic glycocarbonates and linear polyglycocarbonates by polycondensation from glycans

专利号:WO-2005012319-A1
优先权日:2003-07-31
标 题:Production of 2-18f-2-deoxy-d-glucose via solid-phase synthesis

专利号:EP-1648912-A1
优先权日:2003-07-31
标题:Production of 2-18f-2-deoxy-d-glucose via solid-phase synthesis