CAS: 317-20-4; 7-Fluoroindoline-2,3-Dione

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CAS号349-24-6 N-(2-Fluorophen... | CAS号348-54-9 邻氟苯胺 | CAS号98968-72-0 (2-氟苯基)氨基甲酸叔丁酯 | CAS号71294-06-9 7-Fluoro-3-(met... | CAS号932041-13-9 7-氟-1H-吲唑-3-甲酸甲酯 | CAS号959236-59-0 7-氟-1H-吲唑-3-甲酸 | CAS号825-22-9 2-氨基-3-氟苯甲酸 | CAS号71294-03-6 7-氟-2-吲哚酮 | CAS号1000339-91-2 2-溴-3-氟苯甲酰氯 | CAS号143884-84-8 7-氟-3-(肟基)吲哚啉-2-酮 | CAS号132715-69-6 2-溴-3-氟苯甲酸 | CAS号111721-75-6 2-溴-3-氟苯胺 | CAS号132715-70-9 2-bromo-3-fluor...

N-Boc-2-氟苯胺置于盐酸,叔丁基锂体系中,用 四氢呋喃 作为反应溶剂,化学反应 2.0H,反应生成 7-氟吲哚满二酮
参考文献:合成isatins的一般方法:从苯胺制备区域特异性功能化isatins
标题:合成isatins的一般方法:从苯胺制备区域特异性功能化isatins
摘要:已经开发出一种新方法,用于将取代的苯胺区域特异性地转化为靛红.该方法利用邻位锂化的,受保护的苯胺衍生物与草酸二乙酯的反应来提供α-酮酸酯.氨基部分的水解脱保护伴随有环化作用以提供伊斯丁.
DOI:10.1016/0040-4039(94)85299-5

专利信息

专利号:US-11999757-B2
优先权日:2017-11-01
标 题:Synthesis of boronate ester derivatives and uses thereof
发明人：BOYER SERGE HENRI; HECKER SCOTT J; VERZIJL GERARDUS K M; HERMSEN PETRUS J
权利人:MELINTA SUBSIDIARY CORP
摘要:Disclosed herein are methods for the preparation of boronate derivatives in the synthesis of antimicrobial compounds and uses thereof. Disclosed herein includes method of making a compound of Formula (B) by reducing the ketone group of the keto-ester compound of Formula (A), and the reduction can be performed using a Ruthenium based catalyst system or using an alcohol dehydrogenase bioreduction system.

专利号:US-7754895-B2
优先权日:2005-07-29
标 题:Process for the synthesis of progesterone receptor modulators
发明人：WU YANZHONG; WILK BOGDAN KAZIMIERZ; DING ZHIXIAN; SHI XINXU; WU CHARLES CHAO; RAVEENDRANATH PANOLIL; DURUTLIC HARIS
权利人:WYETH LLC
摘要:Processes for preparing oxindoles, which can be utilized in the preparation of a variety of useful compounds, and methods for minimizing or preventing N-alkylation of amide containing compounds, including oxindoles, are provided. Also provided is a compound of the following structure:

专利号:US-2024279248-A1
优先权日:2017-11-01
标题:Synthesis of boronate ester derivatives and uses thereof

专利号:US-8933248-B2
优先权日:2012-06-21
标 题:3-substituted-3-hydroxy oxindole derivatives and process for preparation thereof
发明人：RAO MANDAPATI MOHAN; PRATHIMA PARVATHANENI SAI
权利人:COUNCIL SCIENT IND RES
摘要:The present invention relates to expedient method for synthesis of 3-substituted-3-hydroxy-oxindole derivatives, which are useful as synthetic precursors to valuable pharmaceutical compounds. These are synthesized by reacting nitromethane with the corresponding isatins of formula (I). The reaction process of isatins was carried using water as a solvent at room temperature to form the corresponding 3-hydroxy-3-nitromethylindolin-2-ones of formula (II).

专利号:US-2007027327-A1
优先权日:2005-07-29
标题 :Process for the synthesis of progesterone receptor modulators

专利号:US-8987195-B2
优先权日:2012-08-08
标 题:HCV NS3 protease inhibitors
发明人：BARA THOMAS; BHAT SATHESH; BISWAS DIPSHIKHA; BROCKUNIER LINDA; BURNETT DUANE A; CHACKALAMANNIL SAMUEL; CHELLIAH MARIAPPAN V; CHEN AUSTIN; CLASBY MARTIN; COLANDREA VINCE J; GUO ZHUYAN; HAN YONGXIN; JAYNE CHARLES; JOSIEN HUBERT; MARCANTONIO KAREN; MIAO SHOUWU; NEELAMKAVIL SANTHOSH; PINTO PATRICK; RAJAGOPALAN MURALI; SHAH UNMESH; VELAZQUEZ FRANCISCO; VENKATRAMAN SRIKANTH; XIA YAN
权利人:MERCK SHARP & DOHME; MERCK CANADA INC
摘要:The present invention relates to hepatitis C virus (HCV) NS3 protease inhibitors containing a spirocyclic moeity, uses of such compounds, and synthesis of such compounds.