CAS: 480-63-7; 2,4,6-Trimethylbenzoic Acid

上下游产品

CAS号487-68-3 2,4,6-三甲基苯甲醛 | CAS号1667-01-2 2',4',6'-三甲基苯乙酮 | CAS号124-38-9 二氧化碳 | CAS号214360-78-8 2.4.6-三甲基苯硼酸新戊二醇酯 | CAS号108-67-8 均三甲苯 | CAS号2282-84-0 2,4,6-三甲基苯甲酸甲酯 | CAS号64-18-6 甲酸 | CAS号2633-66-1 2-均三甲苯基溴化镁 | CAS号4028-63-1 2,4,6-三甲基碘苯 | CAS号4170-90-5 2,4,6-三甲基苄醇 | CAS号106567-41-3 2,4,6-trimethyl... | CAS号527-53-7 1,2,3,5-四甲基苯 | CAS号4170-90-5 2,4,6-三甲基苄醇 | CAS号938-18-1 2,4,6-三甲基苯甲酰氯 | CAS号487-68-3 2,4,6-三甲基苯甲醛 | CAS号3459-92-5 碳酸二苄酯 | CAS号5745-51-7 (2,4,6-trimethy... | CAS号101-99-5 苯基尿烷 | CAS号108-67-8 均三甲苯 | CAS号54401-64-8 5,7-dimethyl-3H...

2,4,6-三甲基苯甲酸甲酯置于me2Alteme体系中,用 甲苯 作为反应溶剂,化学反应 6.0H,以91%的收率获得产物2,4,6-三甲基苯甲酸
参考文献:二甲基铝酸二甲酯铝,一种通过新机制在异常温和条件下裂解受阻甲酯的新试剂
标题:二甲基铝酸二甲酯铝,一种通过新机制在异常温和条件下裂解受阻甲酯的新试剂
摘要:已开发出一种高效有效的新型试剂(me 2 Alteme)2,用于在23oc的甲苯溶液中将甲酯转化为相应的羧酸.
DOI:10.1016/j.Tetlet.2005.05.003

专利信息

专利号:US-11548898-B2
优先权日:2017-07-06
标题 :Synthesis of halichondrins
发明人：KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI
权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD
摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).

专利号:US-5856465-A
优先权日:1996-05-24
标 题:Compositions and methods for the synthesis of chirally pure organophosphorus nucleoside derivatives
发明人：STEC WOJCIECH JACEK; WOZNIAK LUCYNA
权利人:POLSKA AKAD NAUK CENTRUM
摘要:Methods for the stereospecific synthesis of chirally pure organophosphorus dinucleotide derivatives and nucleoside monomer synthons used in their synthesis are provided. These methods allow for conversion of nucleoside intermediates of unchosen sense of P-chirality to nucleoside monomer synthons of chosen sense of P-chirality. Also provided are novel nucleoside intermediates useful in such methods.

专利号:US-2006287520-A1
优先权日:2005-05-16
标 题 :Synthesis of salinosporamide A and analogues thereof
发明人：DANISHEFSKY SAMUEL J; ENDO ATSUSHI
权利人:DANISHEFSKY SAMUEL J; ENDO ATSUSHI
摘要:A novel synthesis of salinosporamide A is provided. Salinospoamide A as well as structurally related natural products, omuralide and lactacystin, have been shown to be proteasome inhibitors. Therefore, these compounds as well as analogues of these natural products may be useful in the treatment of proliferative diseases such as cancer, autoimmune diseases, diabetic retinopathy, etc. The invention provides for the synthesis of salinosporamide A as well as analogs thereof using a convenient point for derivatization of the bicyclic core. Pharmaceutical compositions and method of using the inventive compounds are also provided.

专利号:US-7910623-B2
优先权日:2005-07-22
标 题 :Synthesis of scabronines and analogues thereof
发明人：DANISHEFSKY SAMUEL J; WATERS STEPHEN P
权利人:SLOAN KETTERING INST CANCER
摘要:A novel synthesis of scabronines, which are related to a broader class of angularly fused tricyclic diterpenoids known as cyathanes, is provided. Scabronine G, its methyl ester derivative, and other analogs have been shown to have neurotrophic activity. Therefore, these compounds are particularly useful in treating neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's diseases, etc. The invention provides for the synthesis of scabronines as well as analogs thereof. Pharmaceutical compositions and method of using the inventive compounds are also provided.

专利号:WO-2012047907-A9
优先权日:2010-10-04
标题 :Synthesis of c5-substituted tetracyclines, uses thereof, and intermediates thereto
发明人：MYERS ANDREW G; WRIGHT PETER M; HECKER EVAN
权利人:HARVARD COLLEGE; MYERS ANDREW G; WRIGHT PETER M; HECKER EVAN
摘要:The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The recent development of a modular synthesis of tetracycline analogs through a chiral enone intermediate has allowed for the efficient synthesis of novel tetracycline analogs never prepared before. The present invention provides more efficient routes for preparing the enone intermediate and allows for a wide variety of substituents at position 5 of the tetracycline ring system.

专利号:EP-0850248-B1
优先权日:1995-09-01
标 题 :Compositions and methods for the synthesis of organophosphorus derivatives
发明人：STEC WOJCIECH J; WOZNIAK LUCYNA
权利人:POLSKA AKAD NAUK CENTRUM
摘要:Methods for the stereospecific synthesis of chirally pure organophosphorus dinucleotide derivatives and nucleoside monomer synthons used in their synthesis are provided. These methods allow for conversion of nucleoside intermediates of unchosen sense of P-chirality to nucleoside monomer synthons of chosen sense of P-chirality. Also provided are novel nucleoside intermediates useful in such methods.