CAS: 59795-89-0; (2-Isocyanoethyl)Benzene

该化合物是一种有机化合物,其组成为附于苯乙基脚架上的活性异氰化物功能组,该结构使其成为合成有机化学中有价值的中间体,特别是用于诸如Ugi或Passerini反应等多成分反应,作为异氰化物的组成部分.其温和条件下的稳定性和反应性使得能够高效地建造复杂的异丙循环和消化器.芳香联苯组会提高有机溶剂的溶解性,便利各种合成议定书的处理.由于其多功能性,苯(2-Isocyano乙基)广泛用于医药化学和材料科学,以开发具有定制特性的新化合物.由于异氰化物的潜在乳液效应,需要妥善处理.

结构式图片

欧盟法规

ECHA物质C&L通报

上下游产品

2-Phenylethylis°Cyaniddichlorid N-(2-phenylethyl)formamide chloroform phenethylamine 2-Phenylethylis°Cyaniddichlorid (S)-2-[2-([1-Phenethylcarbamoyl-2-((2S,3R,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yl)-ethyl]-{3-[4-(4-phenoxy-phenoxy)-phenyl]-propionyl}-amino)-acetylamino]-pentanedioic acid dibenzyl ester (S)-2-{(1-Phenethylcarbamoyl-ethyl)-[2-((2R,3R,4R,5R,6R)-3,4,5-tris-benzyloxy-6-phenoxymethyl-tetrahydro-pyran-2-yl)-acetyl]-amino}-pentanedioic acid dibenzyl ester (S)-2-(2-{{1-Phenethylcarbamoyl-3-[4-(4-phenoxy-phenoxy)-phenyl]-propyl}-[2-((2S,3R,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yl)-acetyl]-amino}-acetylamino)-pentanedioic acid dibenzyl ester

合成工艺路线路线简述

    1-苄基-1-甲苯磺酰甲基异丁酯置于四丁基碘化铵体系中,用 乙腈 作为反应溶剂,以48%的收率获得产物苯乙基乙腈
    参考文献:Hess,Ulrich; Brosig; Komenda,Pharmazie,1999,Vol. 54,# 6,P. 412-417
    标题:Hess,Ulrich; Brosig; Komenda,Pharmazie,1999,Vol. 54,# 6,P. 412-417

    海关参考信息

    专利信息


    专利号:WO-2009115333-A1
    优先权日:2008-03-20
    标 题:Novel synthesis of praziquantel
    发明人:DOEMLING ALEXANDER
    权利人:DOEMLING ALEXANDER
    摘要:The present invention discloses a novel and efficient synthesis of praziquantel (I).

    专利号:US-9884316-B2
    优先权日:2014-03-10
    标题:Mononuclear ruthenium complex and organic synthesis reaction using same
    发明人:NAGASHIMA HIDEO; SUNADA YUSUKE; OGUSHI HAJIME; SAKUTA KOJI
    权利人:UNIV KYUSHU NAT UNIV CORP; SHINETSU CHEMICAL CO
    摘要:A neutral or cationic mononuclear ruthenium divalent complex represented by formula (1) can actualize exceptional catalytic activity in at least one reaction among a hydrosilylation reaction, hydrogenation reaction, and carbonyl compound reduction reaction. n n(In the formula, R 1 -R 6 each independently represent a hydrogen atom or an alkyl group, aryl group, aralkyl group, organooxy group, monoorganoamino group, diorganoamino group, monoorganophosphino group, diorganophosphino group, monoorganosilyl group, diorganosilyl group, triorganosilyl group, or organothio group optionally substituted by X; at least one pair comprising any of R 1 -R 3 and any of R 4 -R 6 together represents a crosslinkable substituent; X represents a halogen atom, organooxy group, monoorganoamino group, diorganoamino group, or organothio group; L each independently represent a two-electron ligand other than CO and thiourea ligands; two L may bond to each other; and m represents an integer of 3 or 4.)

    专利号:US-10363551-B2
    优先权日:2015-03-09
    标 题:Mononuclear iron complex and organic synthesis reaction using same
    发明人:NAGASHIMA HIDEO; SUNADA YUSUKE; SAWANO Mina; NODA DAISUKE; SAKUTA KOJI
    权利人:UNIV KYUSHU NAT UNIV CORP; SHINETSU CHEMICAL CO
    摘要:A mononuclear iron bivalent complex having iron-silicon bonds, which is represented by formula (1), can exhibit an excellent catalytic activity in at least one reaction selected from three reactions, i.e., a hydrosilylation reaction, a hydrogenation reaction and a reaction for reducing a carbonyl compound. n n n n n n n n n n (In the formula, R 1 to R 6 independently represent a hydrogen atom, an alkyl group which may be substituted by X, or the like; X represents a halogen atom, or the like; L 1 represents at least one two-electron ligand selected from an isonitrile ligand, an amine ligand, an imine ligand, a nitrogenated heterocyclic ring, a phosphine ligand, a phosphite ligand and a sulfide ligand, wherein, when multiple L 1 's are present, two L 1 's may be bonded to each other; L 2 represents a two-electron ligand that is different from a CO ligand or the above-mentioned L 1 , wherein, when multiple L 2 's are present, two L 2 's may be bonded to each other; and m 1 represents an integer of 1 to 4 and m 2 represents an integer of 0 to 3, wherein the sum total of m 1 and m 2 (i.e., m 1 +m 2 ) satisfies 3 or 4.)

    专利号:JP-H10245678-A
    优先权日:1990-12-31
    标 题 :Selective chemical vapor deposition of copper metal film and synthesis of Cu + 1 (β-diketonate) olefin composite

    专利号:JP-H0649942-B2
    优先权日:1990-12-31
    标题:Chemical vapor deposition method of copper metal film, selective etching method and synthesis method of Cu + 1 (β-diketonate) -olefin composite

    专利号:CN-107141295-A
    优先权日:2017-05-27
    标 题 :A simple synthesis method of uracil derivatives
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    合成参考文献


    摘要:Kroon, E.; Zarganes Tzitzikas, T.; Neochoritis, C. G.; Dömling, A., Science of Synthesis: Applications of Domino Transformations in Organic Synthesis, (2015) 2, 428.
    摘要:Kroon, E.; Zarganes Tzitzikas, T.; Neochoritis, C. G.; Dömling, A., Science of Synthesis: Applications of Domino Transformations in Organic Synthesis, (2015) 2, 422.
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