CAS: 65914-17-2; (2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-(4-Hydroxystyryl)Phenoxy)-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-3,4,5-Triol

上下游产品

cis-3,5-dihydroxy-4'-methoxystilbene 3-O-β-D-glucopyranoside (E)-5-hydroxy-4'-methoxy-3-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyloxy)stilbene (E)-3-(β-D-glucopyranosyloxy)-5-hydroxy-4'-methoxystilbene (E)-5-[2-4-(hydroxyphenyl)ethenyl]-1,3-benzenediol(E)-5-[2-4-(hydroxyphenyl)ethenyl]-1,3-benzenediol (E)-1-(3-methoxy-5-(β-D-glucopyranosyloxy)phenyl)-2-(4'-methoxyphenyl)ethene cis-piceid

(E)-5-Hydroxy-4'-Methoxy-3-(2,3,4,6-Tetra-O-Acetyl-β-D-Glucopyranosyloxy)Stilbene置于sodium Methylate,乙硫醇钠体系中,用 甲醇,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 12.0H,反应生成 虎杖甙
参考文献:Synthesis Of Biologically Active Polyphenolic Glycosides (Combretastatin And Resveratrol Series)
标题:Synthesis Of Biologically Active Polyphenolic Glycosides (Combretastatin And Resveratrol Series)
摘要:(E)−3−(葡萄糖-β−d−果糖氧基)−4',5-二羟基联苯(resveratrol 3−β−d− Glucoside,梦他tributes A−1),(2)− 2',3'-二羟基−3,4,4',5-四甲氧基−联苯(combretastatin A−1),(Z)−3'-羟基−3,4,4',5-四甲氧基−联苯 (Combretastatin A−4),(Z)−2'-羟基−3,4,4',5-四甲氧基−联苯 (Combretastatin Iso−a−4),α,β−双氢−2',3'-二羟基−3,4,4',5-四甲氧基−联苯(combretastatin B−1)及其相应的葡萄糖化物和相关物质通过 Wittig 反应和转移膜催化合成了.目前所合成的大部分化合物已经进行了生物活性测试(细胞抑制,细胞毒性,拟使之 Arrest,神经毒性和抗血小板聚集作用). (C) 1997 Elsevier Science Ltd.
DOI:10.1016/s0008-6215(97)00087-6

专利信息

专利号:US-7705188-B2
优先权日:2002-04-10
标 题:Structural modification of resveratrol: sodium resverastatin phosphate
发明人：PETTIT GEORGE R; GREALISH MATTHEW P
权利人:UNIV ARIZONA
摘要:Described herein are novel compounds having antineoplastic and antimicrobial activity, obtained via structural modifications of resveratrol and combretastatin A-4, methods for synthesis of these compounds, and their use in pharmaceutical composition and for use in the treatment of mammals having cancer. Examples of the novel compounds are: (Z)- and (E)-3,4′,5-trimethoxystilbene (4a, 4b); (Z)- and (E)-3,5-dimethoxy-4′-hydroxystilbene (14c, 14d); (Z)- and (E)-3-hydroxy-4′,5-dimethoxystilbene (14g, 14h); (Z)- and (E)-3,5-dihydroxy-4′-methoxy-stilbene (14k, 14l); sodium resverastatin dibenzyl phosphate ((Z)-3,5-dimethoxy-4-[O-bis(benzyl)phosphoryl]-stilbene) (14m); and sodium resverastatin phosphate (14n).

专利号:US-12227788-B2
优先权日:2014-11-12
标题 :Compositions, methods and treatments for inhibiting cell adhesion and virus binding and penetration
发明人：MATTA KHUSHI L
权利人:TUMOREND LLC
摘要:Disclosed herein are glyco-decoy acceptor compositions that sidetrack or inhibit the activity of biosynthetic enzymes participating in synthesis of ligands binding at selectin, galectin and siglecs receptors; methods of their preparation and uses in drug discovery and in treatments of diseases.

专利号:US-6479466-B1
优先权日:1999-08-13
标题:Compositions for treating viral infections, and methods therefor
发明人：REDFIELD ROBERT R; DAVIS JR CHARLES E; HEREDIA ALONSO
权利人:UNIV MARYLAND; UNIV MARYLAND BIOTECH INST
摘要:Methods and combinations of an agent that promotes DNA synthesis in a virally-targeted cell and a nucleoside analogue having antiviral activity are provided for treating a viral infection in a subject in need thereof. Such compositions are particularly effective where the subject has resistance to a nucleoside analogue, where the subject has resting cellular reservoirs of such a virus, or to induce a post-treatment period of replication incompetence of such a virus.

专利号:WO-2009105123-A1
优先权日:2008-02-22
标 题:Compounds, compositions and methods for treating or preventing diseases
发明人：DANISHEFSKY SAMUEL J; CHOU TING-CHAO; LEI XIAOGUANG
权利人:UNIV COLUMBIA; DANISHEFSKY SAMUEL J; CHOU TING-CHAO; LEI XIAOGUANG
摘要:The present invention provides compounds of Formula (I), compositions comprising an effective amount of a Compound of Formula (I), optionally with a tubulin-binding drug, methods of their use for treating or preventing cancer or a neurotrophic disorder, inducing a chemoprotective phase II enzyme, DNA, or protein synthesis, enhancing the immune system, and methods for making Compounds of the invention.