CAS: 675-14-9; 2,4,6-Trifluoro-1,3,5-Triazine

该化合物是一种高度活性三氟甲基乙基环环化合物,主要用作有机合成和制药制造中的一种多用途中间体,其三氟代三联苯核心具有很强的电益特性,能够产生有效的核生殖替代反应,该化合物因其能够将三氟甲基组引入目标分子,提高其代谢稳定性和亲脂性而特别受到重视,在合成农用化学品,染料和特殊聚合物中发现应用情况,氟原子有助于提高衍生产品的热和化学抗药性,处理需要适当的安全措施,因为它具有核分裂素和对湿度敏感的特性,建议在惰性条件下储存以保持稳定性.

结构式图片

相似化合物

7709-13-9 933-20-0 30894-74-7

欧盟法规

ECHA物质ECHA物质C&L通报REACH预注册

上下游产品

CAS号108-77-0 氰尿酰氯 | CAS号7783-56-4 三氟化锑 | CAS号7783-60-0 四氟化硫 | CAS号1495-50-7 cyanogen fluoride | CAS号696-85-5 2-chloro-4,6-di... | CAS号696-84-4 2,4-dichloro-6-... | CAS号506-78-5 碘化氰 | CAS号7276-63-3 bis{bis(trifluo... | CAS号506-77-4 氯化氰 | CAS号102-54-5 二茂铁 | CAS号1973-05-3 N2,N4,N6-三苯基-1,... | CAS号7783-54-2 三氟化氮 | CAS号75-73-0 四氟化碳 | CAS号666-95-5 Perfluor-(1,4-d... | CAS号1495-50-7 cyanogen fluoride | CAS号353-85-5 三氟乙腈 | CAS号371-71-1 1,1-difluoro-N-... | CAS号877-89-4 三聚氰酸三甲酯

合成工艺路线路线简述

    碘化氰置于mercury(II) Fluoride体系中,用 Neat (No Solvent) 作为反应溶剂,化学反应生成 三聚氟氰
    参考文献:Hueckel,W.,1946,P. 36-37
    标题:Hueckel,W.,1946,P. 36-37

    专利信息


    专利号:US-2021053913-A1
    优先权日:2019-08-22
    标题 :Process for the Synthesis of Fluorinated Conductive Salts for Lithium Ion Batteries
    发明人:ZHOU CHANGYUE; DU HONGJUN; WU WENTING
    权利人:FUJIAN YONGJING TECH CO LTD
    摘要:The invention relates to a new process for the synthesis of fluorinated conductive salts for lithium ion batteries (Li-ion batteries). The said fluorinated conductive lithium ion (Li-ion) battery salts of interest in the framework of the present inventions synthesis process, for example, are Li-ion salts such as LiFSI (lithium bis-(fluoromethanesulfonlyl) imide), LiTFSI (lithium bis-(trifluormethanesulfonlyl) imide), and LiTFSFI (lithium trifluoromethanesulfonylfluorosulfonyl imide), with the formulas as displayed in the Table I herein below. LiFSI, LiTFSI and LiFSTFSI are the most promising conducting salts for Lithium ion batteries and essential for future electromobility.

    专利号:US-2023286918-A1
    优先权日:2020-07-02
    标 题:Manufacturing process for 3,5-dichloropicolinonitrile for synthesis of vadadustat
    发明人:JURKAUSKAS VALDAS; JUNG YOUNG CHUN; KWON TAESOO; KANNAN ARUNACHALAM; GONDI VIJAYA BHASKER
    权利人:AKEBIA THERAPEUTICS INC
    摘要:Disclosed herein are methods and processes of preparing vadadustat or a pharmaceutically acceptable salts thereof, and intermediates (e.g., a compound of Formula (I), (I-F), (II), or (IV), or a pharmaceutically acceptable salts thereof) useful for the synthesis of vadadustat.

    专利号:US-3641020-A
    优先权日:1969-01-23
    标 题 :Synthesis of cyanuric fluoride
    发明人:ANDERSON RICHARD W; FRICK HUGHIE R
    权利人:DOW CHEMICAL CO
    摘要:A PROCESS FOR THE EFFICIENT SYNTHESIS OF CYANURIC FLUORIDE IS PROVIDED. THE PROCESS COMPRISES CONTACTING CERTAIN CYANURIC HALIDES WITH SELECTED ALKALI METAL FLUORIDES IN THE PRESENCE OF A PERHALOCARBONYL COMPOUND. THE PROCESS OF THE PRESENT INVENTION PROVIDES FOR THE PRODUCTION OF CYANURIC FLUORIDE AT CONSIDERABLY REDUCED TEMPERATURES, THAN THOSE USED IN KNOWN PROCESSES.

    专利号:US-2008221303-A1
    优先权日:2004-02-18
    标 题:Method for the Preparation of Peptide-Oligonucleotide Conjugates
    发明人:KATZHENDLER JEHOSHUA; KLAUZNER YAKIR; BEYLIS IRENA; MIZHIRITSKII MICHAEL; SHPERNAT YAACOV; ASHKENAZI BORIS; FRIDLAND DMITRI
    权利人:KATZHENDLER JEHOSHUA; KLAUZNER YAKIR; BEYLIS IRENA; MIZHIRITSKII MICHAEL; SHPERNAT YAACOV; ASHKENAZI BORIS; FRIDLAND DMITRI
    摘要:The present invention relates to the synthesis of peptide-oligonucleotide conjugates (POC). More specifically, the invention relates to a novel method for the preparation of peptide-oligonucleotide conjugates, which can be conducted under mild conditions on solid support, can be performed manually or by a synthesizer, can be used to synthesize alternating sequences of peptides and oligonucleotides, and is applicable to the synthesis of a wide variety of peptide-oligonucleotide conjugates constructed from alternate peptide and oligonucleotide blocks.

    专利号:US-2025188022-A1
    优先权日:2022-02-07
    标 题 :Process for the preparation of nafamostat, camostat and their derivatives
    发明人:AHMED RIYAZ; KUMAR GULSHAN; MAHAJAN SHEENA; Verma Praveen Kumar; CHAM PANKAJ SINGH; KUMAR AMIT; AHMED QAZI NAVEED; REDDY DUMBALA SRINIVASA; SHANKAR RAVI; SINGH PARVINDER PAL
    权利人:COUNCIL SCIENT IND RES
    摘要:The invention provides a novel, economical and practical route for the synthesis of an ester from acid and alcoholic functionalities using Trihalotriazine as coupling agent. Specifically, the invention provides a novel, economical and practical route for the preparation of Nafamostat and Camostat. Synthesis of p-guanidinobenzoic acid (Al) was also achieved from thiourea and p-aminobenzoic acid by using trihalotriazine as coupling reagent.

    专利号:US-2022233673-A1
    优先权日:2019-06-04
    标 题:METHODS OF PRODUCING SHIGA TOXIN B-SUBUNIT (STxB) MONOMERS AND OLIGOMERS, AND USES THEREOF
    发明人:BILLET ANNE; SCHMIDT FRÉDÉRIC; JOHANNES LUDGER; SERVENT DENIS; MOURIER GILLES; TARTOUR ÉRIC; KAY MICHAEL; FULCHER JAMES M
    权利人:INST CURIE; CENTRE NAT RECH SCIENT; INST NAT SANTE RECH MED; COMMISSARIAT A LENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES CEA; APHP ASSIST PUBLIQUE HOPITAUX DE PARIS; UNIV PARIS; UNIV OF UTAH RESEARCH FOUDATION; UNIV UTAH RES FOUND
    摘要:A method of producing a monomer of a Shiga toxin B-subunit (STxB) protein or of a variant thereof by peptide chemical synthesis, as well as to a method of producing a pentamer of the STxB protein or of the variant thereof. The methods are particularly advantageous as they overcome major issues typically observed in peptide chemical synthesis, including solubility and purity issues.
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    主要参考文献

    [参考文献]: G Coffe, Et Al. Chemical Reactivity Of The Tyrosyl Residues In Yeast Hexokinase. Properties Of The Nitroenzyme. Biochim Biophys Acta. 1977 Oct 13;484(2):322-35.
    [参考文献]: M J Gorbunoff, Et Al. [参考文献]: Young Shik Chi, Et Al. Reactivity Of Acid Fluoride-Terminated Self-Assembled Monolayers On Gold. Langmuir. 2007 Jan 30;23(3):1209-14.

    合成参考文献


    摘要:Beweries, T.; Rosenthal, U., Science of Synthesis Knowledge Updates, (2011) 4, 33.
    摘要:U.S. Environmental Protection Agency. 1998. Extremely Hazardous Substances (EHS) Chemical Profiles and Emergency First Aid Guides. Washington, D.C.: U.S. Government Printing Office.
    摘要:Lai, J.; Thomson, B. J.; Sammis, G. M., Science of Synthesis: Modern Strategies in Organofluorine Chemistry , (2024) 1, 19.
    参考文献:10.1007/bf01388172
    摘要:Constantinou-Kokotou V, Kokotos G. Synthesis of optically active lipidic alpha-amino acids and lipidic 2-amino alcohols. Amino Acids. 1999;16(3-4):273–85. doi: 10.1007/bf01388172.
    参考文献:10.1007/bf01388175
    摘要:Palomo C, Aizpurua JM, Ganboa I, Oiarbide M. From beta-lactams to alpha- and beta-amino acid derived peptides. Amino Acids. 1999;16(3-4):321–43. doi: 10.1007/bf01388175.
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