CAS: 69355-99-3; (2R,3S)-3-(Benzyloxy)-2-((Tert-Butoxycarbonyl)Amino)Butanoic Acid

相似化合物

117872-75-0 15260-10-3 2592-18-9

上下游产品

CAS号100-39-0 溴化苄 | CAS号2592-18-9 B°C-L-苏氨酸 | CAS号168034-31-9 B°C-O-苄基-D-苏氨醇

溴甲苯,N-α-叔丁氧羰基-D-苏氨酸 在 Sodium Hydride体系中,获得 BOC-O-Benzyl-D-Threonine
参考文献:脱氢寡肽.十七,从 L-和 D-苏氨酸衍生物实际合成 N,N-保护的 2,3-二氨基丁酸的所有非对映异构体
标题:脱氢寡肽.十七,从 L-和 D-苏氨酸衍生物实际合成 N,N-保护的 2,3-二氨基丁酸的所有非对映异构体
摘要:在某些肽抗生素和毒素中发现的所有 2,3-二氨基丁酸的非对映异构体的合成都已完成.这四种异构体主要通过两种途径衍生,包括 L-或 D-苏氨酸衍生物的 β-取代基的 Sn2 反转.检查了用于 Sn2 反转的各种保护基团和有效的亲核试剂.
Doi:10.1246/Bcsj.68.1369

专利信息

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:WO-2005095371-A1
优先权日:2004-03-31
标 题:Synthesis of chiral furan amino acids as novel peptide building blocks