CAS: 136310-93-5; Rel-(1R,2R,4S,5S,7S)-7-(2-Hydroxy-2,2-Di(Thiophen-2-yl)Acetoxy)-9,9-Dimethyl-3-Oxa-9-Azatricyclo[3.3.1.02,4]Nonan-9-Ium Bromide

专利信息

专利号:US-2006167025-A1
优先权日:2004-12-22
标 题:Tricyclic amino alcohols, processes for synthesis of same and use of same as anti-inflammatory drugs
发明人：BERGER MARKUS; SCHMEES NORBERT; SCHAECKE HEIKE; BAURLE STEFAN; REHWINKEL HARTMUT; MENGEL ANNE; KROLIKIEWICZ KONRAD; GROSSBACH DANJA; VOIGTLAENDER DAVID
权利人:BERGER MARKUS; SCHMEES NORBERT; SCHAECKE HEIKE; BAURLE STEFAN; REHWINKEL HARTMUT; MENGEL ANNE; KROLIKIEWICZ KONRAD; GROSSBACH DANJA; VOIGTLAENDER DAVID
摘要:The invention relates to tricyclic amino alcohols of general formula (I) n nmethod for synthesis of same and use of same as anti-inflammatory agents.

专利号:WO-2018154596-A1
优先权日:2017-02-22
标 题 :Process for synthesis of tiotropium bromide monohydrate
发明人：REDDY G NITHUN; REDDY G SAMHITHA; REDDY G MADAALASA; RAMANI M; REDDY G PRATAP
权利人:GBR LABORATORIES PVT LTD; RACHANA PHARMA TECH
摘要:Provided herein is a process for synthesis of tiotropium bromide wherein the coupling of scopine with 2, 2-dithienyl glycolate is achieved by a two step process under mild conditions.

专利号:US-2025206743-A1
优先权日:2022-03-25
标 题:Tyk2 inhibitor synthesis and intermediates thereof
发明人：MASSE CRAIG E; PHADKE AVINASH S; LAWSON JON P; LEVY STUART; YANG XIAOWEI; WU GUISHENG; FAN SHUFENG
权利人:TAKEDA PHARMACEUTICALS CO
摘要:Described herein are methods of synthesis of a tyrosine-protein kinase 2 (TYK2) inhibitor and to intermediate compounds of the synthesis and methods of making the intermediates. Also provided are pharmaceutically acceptable compositions including compounds prepared by the synthetic method and methods of treating disorders using the same.

专利号:WO-2013046138-A1
优先权日:2011-09-27
标 题:Process for the preparation of scopine esters
发明人：CIPOLLONE AMALIA; FATTORI DANIELA; FINCHAM CHRISTOFER INGO
权利人:LUSOCHIMICA SPA
摘要:The present invention relates to a process for the preparation of scopine esters, as intermediates in the synthesis of tiotropium bromide. In particular, it relates to a transesterification process between scopine alcohol and an ester of a carboxyl acid in high yields and under conditions suitable for industrial use.

专利号:WO-2021133280-A1
优先权日:2019-12-27
标 题 :An improved process for preparation of scopine hydrobromide
发明人：HAAS PHILIPP DANIEL; STECKEL HARTWIG ANDREAS; BELLUR ATICI ESEN; AYDIN FATMA GÖZDE
权利人:DEVA HOLDING
摘要:The present invention relates to an efficient and industrially advantageous process for the preparation of scopine free base or salts. Said compounds are important intermediates in the synthesis of tiotropium and pharmaceutically acceptable salts thereof. The method provided for preparing scopine free base or its salts has the advantages of a simple operation, high yield and low costs.

专利号:WO-2018055642-A1
优先权日:2016-09-23
标 题:A process for preparing tiotropium bromide and intermediates thereof
发明人：REDDY G NITHUN; REDDY G SAMHITHA; REDDY G MADAALASA; RAMANI M; REDDY G PRATAP
权利人:GBR LABORATORIES PVT LTD; RACHANA PHARMA TECH
摘要:Provided herein is a process for synthesis of tiotropium bromide and a process for synthesis of scopine starting from a dimethyl tartarate compound. The synthetic sequence comprises a double Mannich reaction (Robinson-Schopf reaction).