CAS: 145013-05-4; N,N'-Bis-Tert-Butoxycarbonylthiourea

相似化合物

598-52-7 621-83-0 534-13-4

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CAS号24424-99-5 二碳酸二叔丁酯 | CAS号34619-03-9 碳酸二叔丁酯 | CAS号199536-01-1 3-氨基-5-氰基苯甲酸甲酯 | CAS号160677-41-8 mono-6-n-dib°C-... | CAS号884197-54-0 N-(3,4-二甲基异噁唑-5-基)胍 | CAS号46234-16-6 2-[(4-methoxyph... | CAS号41651-87-0 4-[(hydrazinylm...

二碳酸二叔丁酯置于碳酸氢钠,硫脲体系中,用 四氢呋喃 用作溶剂,以60%的收率获得n,N'-二-Boc-硫脲
参考文献:Derivatives Of Pyrimido[6.1-A]Isoquinolin-4-One
标题:Derivatives Of Pyrimido[6.1-A]Isoquinolin-4-One
摘要:该发明提供了通式(i)的化合物或其盐: 其中,R1和rx分别独立表示c1-6烷基或c2-7酰基;X表示och2或cr3R4基团;R3或r4分别独立表示氢原子或c1-3烷基;R5表示氢原子或c1-3烷基,C2-3烯基或c2-3炔基;R6表示氢原子或c1-6烷基,C2-6烯基,C2-6炔基,氨基,C1-6烷基氨基,二(c1-6)烷基氨基或c2-7酰氨基;R7和r8分别独立表示氢或卤素原子,羟基,三氟甲基,C1-6烷基,C2-6烯基,C2-6炔基,C2-7酰基,C1-6烷基硫基,C1-6烷氧基,C3-6环烷基;R9表示氢或卤素原子,羟基,三氟甲基,C1-6烷基,C2-6烯基,C2-6炔基,C2-7酰基,C1-6烷基硫基,C1-6烷氧基或c3-6环烷基.该化合物或其盐可用于治疗哮喘等呼吸系统疾病.该发明的化合物比已知的化合物特雷昆辛(9,10-二甲氧基-3-甲基-2-间二甲苯亚基-2,3,6,7-四氢-4H-嘧啶并[6,1-A]异喹啉-4-酮)具有更长的作用持续时间.

专利信息

专利号:WO-2008105759-A1
优先权日:2007-02-27
标 题:Methods for synthesis of modified peptides
发明人：BROWER JUSTIN O
权利人:ARGOLYN BIOSCIENCE INC; BROWER JUSTIN O
摘要:Methods for the synthesis of peptides and peptide analogs containing aminoacid residues bearing substituted amino- and guanido- sidechains, such as alkyl lysine and arginine residues, are provided.

专利号:US-7888337-B2
优先权日:2007-08-31
标 题 :Synthesis of oseltamivir containing phosphonate congeners with anti-influenza activity
发明人：WONG CHI-HUEY; FANG JIM-MIN; SHIE JIUN-JIE; CHENG YIH-SHYUN EDMOND; JAN JIA-TSRONG
权利人:ACADEMIA SINICA
摘要:Novel phosphonate compounds are described. The compounds have activity as neuraminidase inhibitors against wild-type and H274Y mutant of H1N1 and H5N1 viruses. The present disclosure also provides an enantioselective synthetic route to known neuraminidase inhibitors oseltamivir and the anti-flu drug Tamiflu®, as well as novel phosphonate compounds, via D-xylose. Another efficient and flexible synthesis of Tamiflu and the highly potent neuraminidase inhibitor Tamiphosphor was also achieved in 11 steps and >20% overall yields from the readily available fermentation product (1S-cis)-3-bromo-3,5 -cyclohexadiene-1,2-diol. Most of the reaction intermediates were obtained as crystals without tedious purification procedures. The key transformations include an initial regio- and stereoselective bromoamidation of a bromoarene cis-dihydrodiol, as well as the final palladium-catalyzed carbonylation and phosphonylation.

专利号:EP-1567195-B1
优先权日:2002-11-26
标题 :Dendrimer conjugates for selective solubilisation of protein aggregates
发明人：HEEGAARD PETER; BOAS ULRIK
权利人:UPFRONT CHROMATOGRAPHY AS
摘要:Dendrimer conjugates are presented, which are formed between a dendrimer and a protein solubilising substance. Such dendrimer conjugates ar effective in the treatment of protein aggregate-related diseases (e.g. prion-related diseases). The protein solubilising substance and the dendrimer together show a protein aggregate solubilising effect higher than a physical mixture of the dendrimer and the protein solubilising substance (i.e. a synergistic effect). Such dendrimer conjugates are useful in the treatment or prevention of protein aggregate-relates diseases, in disinfection/decontamination processes and in classifying or identifying protein aggregates. The synthesis of such dendrimer conjugates from readily-available starting materials is described.

专利号:US-2004053999-A1
优先权日:1997-09-17
标题 :Novel compounds and methods for synthesis and therapy
发明人：BISCHOFBERGER NORBERT W; DAHL TERRENCE C; HITCHCOCK MICHAEL J M; KIM CHOUNG U; LEW WILLARD; LIU HONGTAO; MILLS ROGER G; WILLIAMS MATTHEW A
摘要:Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.

专利号:US-6225341-B1
优先权日:1995-02-27
标 题:Compounds and methods for synthesis and therapy
发明人：BISCHOFBERGER NORBERT W; KIM CHOUNG U; LEW WILLARD; LIU HONGTAO; WILLIAMS MATTHEW A
权利人:GILEAD SCIENCES INC
摘要:Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.

专利号:WO-0009116-A1
优先权日:1998-08-14
标 题:Grp receptor ligands
发明人：XIANG JIA-NING; KARPINSKI JOSEPH M; CHRISTENSEN SIEGFRIED B IV
权利人:SMITHKLINE BEECHAM CORP; XIANG JIA NING; KARPINSKI JOSEPH M; CHRISTENSEN SIEGFRIED B IV
摘要:Novel GRP receptor antagonists are provided. Methods of using the present compounds to antagonize GRP receptors are also provided. The present invention further involves the synthesis of the present compounds.