CAS: 155-41-9; Scopolamine Methobromide

该化合物是一种来自二甲胺的四氨基化合物,该物质是一种从Henbane和Belladonna等植物获得的碱性碱性碱性物质,其特点是能够作为抗胆碱性激素剂,主要阻断肌肉受体的乙酰胆碱酯酶作用,在临床环境中经常使用该物质防止运动疾病,并控制过度唾液化和支气分泌的症状.该二甲胺形式提高了其溶性性和生物利用率,使其更有效地用于治疗用途.从化学角度讲,该物质以相对稳定的结构著称,有助于其药理特性.该化合物通常通过注射或口腔方式施用,其副作用可能包括口干燥,视力模糊,以及对抗胆碱性药物很常见的挥发性.

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CAS号74-83-9 溴甲烷

合成工艺路线路线简述

    溴甲烷,Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于苯体系中,化学反应生成甲溴东莨菪碱
    参考文献:Antispasmodics. Viii. Scopolamine Derivatives
    标题:Antispasmodics. Viii. Scopolamine Derivatives
    摘要:
    Doi:10.1021/ja01595A051

    海关参考信息

    专利信息


    专利号:US-6362009-B1
    优先权日:1997-11-21
    标 题 :Solid phase synthesis of heterocycles
    发明人:MUNOZ BENITO; CHEN CHIXU
    权利人:MERCK & CO INC
    摘要:Methods for solid phase and combinatorial synthesis using a resin activation/capture approach are provided. In particular, methods for the production of dihydropyridones, N-acyidihydropyridones, tetrahydropyridones, pyridines, aminopyridines, N-acyltetrahydropyridines and tetrahydropyridines compounds and libraries containing such compounds are provided. Methods for screening the libraries and compounds and pharmaceutical compositions containing compounds prepared by the methods are provided.

    专利号:US-9662318-B2
    优先权日:2012-07-16
    标题 :Bitopic muscarinic agonists and antagonists and methods of synthesis and use thereof
    发明人:BOULOS JOHN
    权利人:BARRY UNIV INC
    摘要:Compositions for treating a condition associated with activity of a muscarinic receptor (e.g., one or more of M 1 , M 2 , M 3 , M 4 , M 5 ) and for anesthetizing a subject include a bitopic muscarinic antagonist or agonist. A bitopic muscarinic antagonist named JB-D4 was discovered. Additional bitopic muscarinic antagonists discovered and described herein include BK-23, HD-42, HD153, HD-185, KH-5, JM-31 and JM-32. These bitopic ligands and their structural analogs, as well as bitopic muscarinic agonists, may be used as neuromuscular blocking agents (e.g., for use in compositions for anesthetizing a subject) and for the treatment of central nervous system disorders (e.g., Parkinson's disease, Schizophrenia, etc.), Overactive Bladder Syndrome, Chronic Obstructive Pulmonary Disease, asthma, and many other diseases associated with the activation or inhibition of M 1 -M 5 acetylcholine receptors.

    专利号:US-2023271983-A1
    优先权日:2020-07-29
    标题 :Functionalized isonitriles and products, preparation and uses thereof
    发明人:SOTELO PÉREZ EDDY; AZUAJE GUERRERO JHONNY ALBERTO; MAJELLARO MARIA
    权利人:UNIV SANTIAGO COMPOSTELA
    摘要:The present invention relates to functionalized isonitrile compounds, formed by means of multicomponent environmentally friendly reactions, suitable for coupling to functional molecules such as biomolecules, APIs, chromophore and fluorophore molecules. The invention also relates to conjugates between said isonitrile compounds and functional molecules, which are useful in the synthesis of pharmaceutic drugs or tools, fluorescent molecules and labels, polymeric smart materials. The invention furthermore provides a kit for the in-vitro preparation of the functionalized isontrile compounds and conjugates. The invention also contemplates the medical use of said compounds and conjugates.

    专利号:EP-2938595-A1
    优先权日:2012-12-27
    标题:Method for the synthesis of a hydrazine that can be used in the treatment of the papilloma virus

    专利号:WO-2014102313-A1
    优先权日:2012-12-27
    标题 :Method for the synthesis of a hydrazine that can be used in the treatment of the papilloma virus

    专利号:US-2014018366-A1
    优先权日:2012-07-16
    标题:Bitopic muscarinic agonists and antagonists and methods of synthesis and use thereof
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    主要参考文献


    1: Oki T, Takagi Y, Inagaki S, Taketo MM, Manabe T, Matsui M, Yamada S. Quantitative analysis of binding parameters of [3H]N-methylscopolamine in central nervous system of muscarinic acetylcholine receptor knockout mice. Brain Res Mol Brain Res. 2005 Jan 5;133(1):6-11. Epub 2003 Jan 24. Russian. Japanese.

    合成参考文献


    摘要:Possible Long-Term Health Effects of Short-Term Exposure to Chemical Agents, National Research Council, 3 vols., Washington, DC, National Academy Press, 1982-85, 1(L1), 1982
    摘要:Archives Internationales de Pharmacodynamie et de Therapie., 180(155), 1969 []
    摘要:Toho Igakkai Zasshi. Journal of Medical Society of Toho University., 17(60), 1970
    摘要:Schafer, E. W., Jr., and W. A. Bowles Jr. 2004. Toxicity, Repellency of Phytotoxicity of 979 Chemicals to Birds, Mammals and Plants. Research Report No. 04-01. National Wildlife Research Center, Fort Collins, Colorado. 118 pp. https://www.aphis.usda.gov/ws/nwrc/chem-effects-db/U_schafer041_2004.pdf
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