CAS: 1615-02-7; 3-(4-Chlorophenyl)Acrylic Acid

相似化合物

49678-02-6 24393-52-0 5676-62-0

上下游产品

CAS号637-87-6 对氯碘苯 | CAS号79-10-7 丙烯酸 | CAS号104-88-1 对氯苯甲醛 | CAS号64-19-7 冰醋酸 | CAS号141-82-2 丙二酸 | CAS号201230-82-2 carbon monoxide | CAS号66482-29-9 (E)-β-bromo-p-c... | CAS号106-39-8 对氯溴苯 | CAS号24393-52-0 对氯肉桂酸乙酯 | CAS号108-24-7 乙酸酐 | CAS号1028252-13-2 4-溴-7-氯异喹啉-1(2H)-酮 | CAS号606-83-7 3,3-二苯基丙酸 | CAS号103-25-3 3-苯丙酸甲酯 | CAS号2019-34-3 3-(4-氯苯基)丙酸 | CAS号501-52-0 3-苯丙酸 | CAS号99-91-2 对氯苯乙酮 | CAS号34576-85-7 3,6-二氯苯并[b]噻吩-2-甲酰氯 | CAS号29900-76-3 3-(4-chlorophen... | CAS号873-73-4 1-氯-4-乙炔基苯 | CAS号104-88-1 对氯苯甲醛

(4-氯苯基)-丙酸乙酯置于吡啶,氢气,Sodium Hydroxide体系中,用 四氢呋喃,甲醇,乙醇,水 用作溶剂,20.0 °C,101.33 Kpa 条件下,反应生成对氯肉桂酸
参考文献:脂肪族烯基酰胺的对映选择性钯催化的氧化级联环化
标题:脂肪族烯基酰胺的对映选择性钯催化的氧化级联环化
摘要:据报道,Pd(tfa)2 /(s,S)-Diph-Pyrox的催化剂体系可在温和的好氧条件下促进链烯键合的脂肪族丙烯酰胺的高效对映选择性氧化级联环化反应.已经以高收率和优异的对映选择性合成了一系列吡咯并咪唑衍生物.氘标记实验表明,该反应以高选择性通过反氨基palpalation(anti-Ap)途径进行.已计算出抗-Ap步骤的过渡态,以说明观测到的对映选择性.
Doi:10.1021/acs.Orglett.6B03410

专利信息

专利号:US-2005080260-A1
优先权日:2003-04-22
标 题 :Preparation of prodrugs for selective drug delivery
发明人：MILLS RANDELL L; WU GUO-ZHANG
摘要:Synthesis of a chemical compound having the formula A-B-C that may serve for applications such as drug delivery where A is a chemiluminescent, moiety, B is a photochromic moiety, and C is a biologically active moiety where A-B-C may serve as a prodrug. Novel synthetic methods of the present invention to form the prodrug comprised the steps of (1) forming a benzophenone, (2) forming a diaryl ethylene, (3) attaching a phthalimide moiety to at least one of the aryl groups of the ethylene to form a phthalimide-ethylene conjugate, (4) condensing two ethylene-phthalimide conjugates to form a phthalimide-pentadiene conjugate, (5) converting the phthalimide to the phthalhydrazide by reaction with hydrazine to form a carrier compound according to the present invention, and (6) reacting the carrier compound with an nucleophilic moiety of the drug to form the corresponding prodrug. Alternatively the carrier can be prepared by using the halo-substituted diaryl ethylene to make the corresponding cationic leuco dye-like compound with known methods. The cationic compound then is protected by reacting with a nucleophile and coupled with the aminophathalimide by palladium-catalyzed amination to form the protected phthalimide-pentadiene conjugate. The latter is refluxed with hydrazine to convert its phthalimide to the phthalhydrazide and acidified to give the carrier. An additional aspect of the present invention relates to the use of these compounds as antiviral agents for the treatment of viral infections such as HIV and as anticancer agents for the treatment of cancers such as bowel, lung, and breast cancer.

专利号:US-6664282-B2
优先权日:1999-09-17
标 题:Synthesis of [3,5,7]-1H-imidazo [1,5-a]imidazol-2 (3H)- one compounds
发明人：ELABDELLAOUI HASSAN M; OSTRESH JOHN M; HOUGHTEN RICHARD A
权利人:TORREY PINES INST
摘要:Individual substituted [3,5,7]-1H-imidazo[1,5-a]imidazol-2(3H)-one compounds and their pharmaceutically-acceptable salts are disclosed, as are libraries of such compounds. Methods of preparing and using the libraries of compounds as well as individual compounds of the libraries are also disclosed.

专利号:US-9085605-B2
优先权日:2010-05-27
标 题:Chemical synthesis and anti-tumor and anti-metastatic effects of dual functional conjugate
发明人：LIU GANG; ZHAO NAN; MA YAO
权利人:LIU GANG; ZHAO NAN; MA YAO; SHENZHEN SALUBRIS PHARM CO LTD
摘要:The present invention discloses chemical synthesis, anti-tumor and anti-metastatic effects of a dual functional conjugate as shown by formula I. Specifically, paclitaxel or docetaxol is linked with muramyl dipeptide derivative to form a conjugate, thus dual anti-tumor and anti-metastatic effects are achieved by combination of chemotherapy and immunotherapy. The present invention also discloses that paclitaxel or docetaxol and muramyl dipeptide derivative conjugate is synthesized by combination of solid-phase and solution-phase synthesis, and said conjugate can be used in manufacture of anti-tumor medicaments as proved by reliable bioassays.

专利号:US-5856107-A
优先权日:1997-02-04
标 题 :Combinatorial libraries of imidazol-pyrido-indole and imidazol-pyrido-benzothiophene derivatives, methods of making the libraries and compounds therein
发明人：OSTRESH JOHN M; HOUGHTEN RICHARD A
权利人:TREGA BIOSCIENCES INC
摘要:The invention provides a rapid approach for combinatorial synthesis and screening of libraries of imidazol-pyrido-indole and imidazol-pyrido-benzothiophene compounds. The present invention further provides methods of preparing the libraries and the individual compounds made by the combinatorial synthesis.

专利号:WO-9834113-A1
优先权日:1997-02-04
标题 :Combinatorial libraries of bicyclic guanidine derivatives and compounds therein
发明人：OSTRESH JOHN M; MEYER JEAN-PHILIPPE; DOOLEY COLETTE T; HOUGHTEN RICHARD A; BLONDELLE SYLVIE E; SCHONER CHRISTA C
权利人:TREGA BIOSCIENCES INC
摘要:The invention provides a rapid approach for combinatorial synthesis and screening of combinatorial libraries of bicyclic guanidine compounds. The present invention further provides the compounds made by the combinatorial synthesis and individually as well as methods of using the same.

专利号:US-6359144-B1
优先权日:1997-02-04
标 题 :Combinatorial libraries of bicyclic guanidine derivatives and compounds therein
发明人：OSTRESH JOHN M; MEYER JEAN-PHILIPPE; DOOLEY COLETTE T; BLONDELLE SYLVIE E; SCHONER CHRISTA C; HOUGHTEN RICHARD A
权利人:LION BIOSCIENCE AG
摘要:The invention provides a rapid approach for combinatorial synthesis and screening of combinatorial libraries of bicyclic guanidine compounds. The present invention further provides the compounds made by the combinatorial synthesis and individually as well as methods of using the same.