CAS: 27876-94-4; (2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-Tetramethylhexadeca-2,4,6,8,10,12,14-Heptaenedioic Acid

上下游产品

西红花酸二甲酯 Crocetindimethylester 5892-54-6
Diethyl 2,7-Dimethylocta-2,4,6-Triene-1,8-Dioate 64768-01-0

栀子黄置于potassium Hydroxide体系中,化学反应生成藏红花酸
参考文献:Effects Of Intestinal Microbiota On Pharmacokinetics Of Crocin And Crocetin In Male Sprague-Dawley Rats
标题:Effects Of Intestinal Microbiota On Pharmacokinetics Of Crocin And Crocetin In Male Sprague-Dawley Rats
摘要:除了肝代谢外,肠道微生物在药物代谢中的作用被认为在异物生物转化中是重要的.藏红花素及其去糖苷基形式藏红花酸,从许多植物中分离出来,包括藏红花的干柱和栀子花果实,已被用于治疗炎症,癌症和代谢紊乱.在这项研究中,通过给予预先用头孢氨苄,土霉素和红霉素等抗生素混合物进行为期三天的连续处理的雄性大鼠单次口服600毫克/千克藏红花,研究了肠道微生物对藏红花药代动力学的影响.在藏红花处理后,通过lc-Ms收集血液,尿液和粪便,评估藏红花和藏红花酸的药代动力学特性.结果表明,与藏红花酸相比,藏红花的肠道吸收相对较少,而藏红花通过肠道微生物代谢为藏红花酸可能是吸收的关键步骤.目前的结果清楚地表明,藏红花的体内药理作用可能主要是由其去糖苷基形式藏红花酸产生的作用,而肠道微生物对糖苷类天然产物的代谢应被考虑以了解它们的药效作用.
Doi:10.3390/metabo10110424

专利信息

专利号:US-12071646-B2
优先权日:2014-09-11
标 题 :Cells comprising mogroside pathway enzymes and uses thereof
发明人：ITKIN MAXIM; DAVIDOVICH-RIKANATI RACHEL; COHEN SHAHAR; PORTNOY VITALY; DORON-FAIGENBOIM ADI; PETREIKOV MARINA; SHEN SHMUEL; TADMOR YAAKOV; BURGER YOSEF; LEWINSOHN EFRAIM; KATZIR NURIT; SCHAFFER ARTHUR A; OREN ELAD
权利人:THE STATE OF ISRAEL MINISTRY OF AGRICULTURE & RURAL DEVELOPMENT AGRICULTURAL RES ORGANIZATION ARO VO
摘要:Isolated mogroside and mogrol biosynthetic pathway enzyme polypeptides useful in mogroside biosynthesis are provided. Mogroside biosynthetic pathway enzymes of the invention include squalene epoxidase (SE), epoxy hydratase (EH), cytochrome p450 (Cyp), cucurbitadienol synthase (CDS) and udp-glucosyl-transferase (UGT), Also provided are methods of producing a mogroside using the isolated mogroside and mogrol biosynthetic enzyme polypeptides, the methods comprising contacting a mogrol and/or a glycosylated mogrol (mogroside) with at least one UDP glucose glucosyl transferase (UGT) enzyme polypeptide of the invention catalyzing glucosylation of the mogrol and/or the glucosylated mogrol to produce a mogroside with an additional glucosyl moietie(s), thereby producing the mogroside. Alternatively or additionally provided is a method of synthesizing a mogrol, the method comprising contacting a mogrol precursor substrate with one or more mogrol biosynthetic pathway enzyme polypeptides as described herein catalyzing mogrol synthesis from the mogrol precursor substrate, thereby synthesizing the mogrol.

专利号:WO-2006097348-A1
优先权日:2005-03-15
标 题:Use of agents such as nonpolymeric nitric oxide donors for making the lips full again and/or colouring the lips
发明人：CALS-GRIERSON MARIE-MADELEINE
权利人:OREAL; CALS-GRIERSON MARIE-MADELEINE
摘要:The invention relates in particular to the cosmetic use (i) of at least one agent for promoting the production of NO in and/or on the lips, chosen from nitric oxide NO donors or precursors; nonpolymeric NO releasers; and NO synthase synthesis and/or activity stimulators; or (ii) of other agents for promoting microcirculation in the skin, chosen from potassium channel openers; calcium channel blockers; phosphodiesterase inhibitors; flavonoids; vasodilator peptides that are not NO donors; temperature modulators; agents for promoting the stimulation and/or maintenance of angiogenesis; agents for promoting the stimulation of endothelial cell proliferation; agents for promoting endothelial cell migration; and mixtures thereof, in a makeup and/or care composition for the lips, as an agent for naturally making the lips full again and/or naturally coloring the lips. It also relates to specific care and/or makeup compositions for the lips containing said agent, and also to a cosmetic process aimed at making the lips naturally full and/or colored, using said compositions .

专利号:CN-114870428-A
优先权日:2022-04-08
标 题 :Production device and working method of preparation for promoting gardenia saffron synthesis