CAS: 36042-94-1; Di-O-Tolylchlorophosphine

上下游产品

2-methylchlorobenzene o-tolyl magnesium chloride di-o-tolylphosphine oxide N-ethyl-N-(di-o-tolylphosphino)ethanamineo-Anisyl-bis-(o-tolyl)-phosphin bis[2-(bis(2-methylphenyl)phosphino)phenyl]ether di(o-tolyl)phosphine o-tolyl-(2-trifluoromethyl-phenyl)-phosphanedi-o-tolyl-(2-trifluoromethyl-phenyl)-phosphane

2-氯甲苯置于magnesium,三氯化磷体系中,用 四氢呋喃 作为反应溶剂,化学反应 6.0H,以54%的收率获得产物二-O-二甲苯氯化磷
参考文献:Effect Of Fluorine And Trifluoromethyl Substitution On The Donor Properties And Stereodynamical Behaviour Of Triarylphosphines
标题:Effect Of Fluorine And Trifluoromethyl Substitution On The Donor Properties And Stereodynamical Behaviour Of Triarylphosphines
摘要:一系列含有2-,3-或4-三氟甲基取代的三芳基膦及其氧化物,硫属化物和fe(Co)4衍生物已被制备并通过光谱学和晶体学进行表征.cf3取代的电子效应是累积的,并且在2,3或4位上感受是相等的.由于空间原因,2位上的取代显著阻碍了其配位能力.通过变温NMR和分子力学计算分析了2-取代衍生物中相关p-c旋转.
DOI:10.1039/a903211H

专利信息

专利号:US-9518014-B2
优先权日:2012-07-20
标 题:Process for synthesis of ezetimibe and intermediates used in said process
发明人：DING KUILING; WANG XIAOMING; WANG ZHENG
权利人:SHANGHAI INST ORGANIC CHEMISTRY CAS
摘要:A process for the production of ezetimibe and intermediates used in said process are disclosed. A kind of Morita-Baylis-Hillman adduct can be altered to chiral carboxylic acid derivatives of β-arylamino α-methylene with high activity and selectivity by means of ally lamination reaction, and the above carboxylic acid derivatives of β-arylamino α-methylene can be altered to the chiral intermediates of ezetimibe by means of simple conversion and further synthesized into the chiral drug ezetimibe. The synthesis route introduces chirality through the use of a chiral catalysis method, thereby avoiding the use of the chiral auxiliary oxazolidinone; and the route is economical and eco-friendly.

专利号:US-2012309997-A1
优先权日:2010-02-12
标 题:Enantiomerically Enriched Aminodiphosphines as Ligands for the Preparation of Catalysts for Asymmetric Synthesis
发明人：ALONSO XALMA MONICA; VERDAGUER ESPAULELLA XAVIER; REVES VILAPLANA MARC; RIERA ESCALE ANTONI
权利人:ALONSO XALMA MONICA; VERDAGUER ESPAULELLA XAVIER; REVES VILAPLANA MARC; RIERA ESCALE ANTONI; ENANTIA S L
摘要:The present invention relates to enantiomerically enriched aminodiphosphine ligands where the chirality is located in the phosphorus atom and their preparation process, to catalysts containing them and their preparation process, as well as their use in asymmetric synthesis.

专利号:US-10093692-B2
优先权日:2013-09-18
标 题 :Phosphines, synthesis thereof and their use in catalysis
发明人：KWONG FUK YEE; WONG SHUN MAN; YEUNG CHUNG CHIU
权利人:UNIV HONG KONG POLYTECHNIC
摘要:The present invention relates to a novel class of benzimidazolyl/imidazolyl phosphine ligands, methods of preparing such ligands via a simple one-pot protocol, and applications of the ligands in catalytic reactions.

专利号:US-2015166479-A1
优先权日:2012-07-20
标 题 :Process for synthesis of ezetimibe and intermediates used in said process

专利号:EP-2876102-A1
优先权日:2012-07-20
标 题 :Process for synthesis of ezetimibe and intermediates used in said process

专利号:EP-2876102-B1
优先权日:2012-07-20
标 题:Process for synthesis of ezetimibe and intermediates used in said process