2-萘甲醚置于氢氧化钾,Hf,乙酸酐体系中,化学反应生成 6-甲氧基-2-乙酰萘 参考文献:Preparation Of 6-Substituted-2-Vinylnaphthalene 标题:Preparation Of 6-Substituted-2-Vinylnaphthalene 摘要:从2-取代萘化合物中形成6-取代-2-乙烯基萘的方法,其中2-位置的取代基是一个对位-邻位导向的电子给予基团,不与氢氟酸发生反应,包括将萘化合物和酰化剂与几乎无水氢氟酸接触,使萘化合物酰化为6-取代-2-酰基萘化合物,将6-取代-2-酰基萘化合物氢化以将2-酰基取代为醇基取代,将氢化产物在有自由基抑制剂存在的情况下脱水以将醇基取代为烯基取代,然后在脱水后分离形成的6-取代-2-乙烯基萘.
专利号:US-RE37813-E 优先权日:1996-02-21 标题 :Process for the synthesis of nabumetone 发明人:CANNATA VINCENZO; BERTONI AMILCARE; BIANCHI STEFANO 权利人:HONEYWELL INT INC 摘要:New process for the synthesis of the antiinflammatory drug known as nabumetone that consists in reacting 2-acetyl-5-bromo-6-methoxynaphthalene with an alkyl acetate in presence of an alkaline alcoholate to get 4-(5-bromo-6-methoxy-2-naphthyl)-4-hydroxybut-3-en-2-one that by catalytic hydrogenation in a polar solvent and in presence of a base gives 4-(6-methoxy-2-naphthyl)butan-2-one known as nabumetone.
专利号:US-11639326-B2 优先权日:2017-04-06 标 题 :Continuous flow synthesis of ibuprofen 发明人:COLLINS NATHAN; MALERICH JEREMIAH; SZETO JUDY; KOZOCAS JOSEPH A 权利人:STANFORD RES INST INT 摘要:This disclosure generally relates to methods of making ibuprofen, naproxen, and derivatives thereof. This disclosure also generally relates to compounds made by the disclosed methods. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
专利号:US-5286902-A 优先权日:1991-04-15 标题:Process for preparation of 2-(6-methoxy-2-naphthyl)propionic acid and intermediates therefor utilizing 2,6-diisopropylnaphthalene 发明人:JAMES DUSTIN K; KOMIN ANDREW P; SIEGMAN JOHN R 权利人:KOCH IND INC 摘要:A process is disclosed for the synthesis of 2-(6-methoxy-2-naphthyl)propionic acid that utilizes 2,6-diisopropylnaphthalene.
专利号:US-9795951-B2 优先权日:2013-05-31 标题 :Delamination of borosilicate layered zeolite 发明人:OUYANG XIAOYING; KATZ ALEXANDER; ZONES STACEY IAN 权利人:OUYANG XIAOYING; KATZ ALEXANDER; ZONES STACEY IAN; CHEVRON USA INC; UNIV CALIFORNIA 摘要:Provided is a surfactant-free, single-step synthesis of delaminated aluminosilicate zeolites. The process comprises the step of heating a borosilicate zeolite precursor in a metal salt solution, e.g., an aluminum nitrate solution, zinc nitrate solution or manganese nitrate solution. The delaminated aluminosilicate zeolite product is then recovered from the solution.
专利号:US-2023372912-A1 优先权日:2022-05-23 标题:One-pot synthesis for delaminated zeolites 发明人:KATZ ALEXANDER; MARTINEZ ABRAHAM; XU LE; ZONES STACEY I 权利人:CHEVRON USA INC; UNIV CALIFORNIA 摘要:Provided is a method of preparing a delaminated Al-SSZ-70 zeolite. The method combines direct hydrothermal synthesis with CTA+ cations and an imidazolium OSDA. A post-synthetic high shear mixing treatment is also preferred. In one embodiment, an Al-SSZ-70 zeolite seed is used, preferably with a Si/Al ratio of at least 50.
专利号:CN-114887656-A 优先权日:2022-06-06 标 题:A kind of preparation method of modified nanometer Hβ zeolite catalyst for selective synthesis of 6-acyl-2-methoxynaphthalene
[参考文献]: B List, Et Al. Aldol Sensors For The Rapid Generation Of Tunable Fluorescence By Antibody Catalysis. Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15351-5. [参考文献]: M Nobilis, Et Al. Comparative Biotransformation And Disposition Studies Of Nabumetone In Humans And Minipigs Using High-Performance Liquid Chromatography With Ultraviolet, Fluorescence And Mass Spectrometric Detection. J Pharm Biomed Anal. 2003 Aug 8;32(4-5):641-56.
合成参考文献
参考文献:10.1007/s10895-011-0923-2 摘要:Kaczmarek M. Chemiluminescence of the Reaction System Ce(IV) - Non-Steroidal Anti-Inflammatory Drugs Containing Europium(III) Ions and its Application to the Determination of Naproxen in Pharmaceutical Preparations and Urine. Journal of Fluorescence. 2011 Jul 13;21(6):2201. doi: 10.1007/s10895-011-0923-2.