CAS: 434-13-9; (R)-4-((3R,5R,8R,9S,10S,13R,14S,17R)-3-Hydroxy-10,13-Dimethylhexadecahydro-1H-Cyclopenta[a]Phenanthren-17-yl)Pentanoic Acid

上下游产品

CAS号1553-56-6 3-Oxo-5β-cholan... | CAS号86931-55-7 (R)-4-((3R,5R,8... | CAS号5130-29-0 12-Ketodeoxycho... | CAS号83-44-3 去氧胆酸 | CAS号4651-66-5 methyl 3α-aceto... | CAS号21059-42-7 methyl 3alpha-[... | CAS号3245-38-3 脱氧胆酸甲酯 | CAS号18207-68-6 3α-(3-carboxy-p... | CAS号83-44-3 去氧胆酸 | CAS号474-25-9 鹅去氧胆酸； 鹅脱氧胆酸 | CAS号4651-67-6 3α-羟基-7-氧代-5β-胆烷酸 | CAS号2955-27-3 熊果酸 | CAS号911-40-0 7-酮-3α,12-α-二羟基胆酸 | CAS号5130-29-0 12-Ketodeoxycho... | CAS号81873-91-8 12-Oxo-ursodeox... | CAS号81-25-4 胆酸 | CAS号434-13-9 石胆酸

胆酸置于吡啶,N-溴代丁二酰亚胺(Nbs),Hydrazine Hydrate,Lithium Hydroxide Monohydrate体系中,用 四氢呋喃,水,丙酮,二乙二醇 作为反应溶剂,化学反应 73.0H,反应生成 石胆酸
参考文献:一种以胆酸为原料合成石胆酸的方法
标题:一种以胆酸为原料合成石胆酸的方法
摘要:本发明公开了一种石胆酸的合成方法,采用胆酸为起始原料,经过3α‑oh选择性保护,7α‑oh,12α‑oh氧化成羰基,水解,黄鸣龙还原,共4步反应合成石胆酸.该方法起始原料易得,价廉,合成步骤简短,副反应少,后处理简单,总收率高,适用于工业化生产.

专利信息

专利号:US-11479577-B2
优先权日:2016-05-18
标题:Intermediates for the synthesis of bile acid derivatives, in particular of obeticholic acid
发明人：WEYMOUTH-WILSON ALEXANDER; KOMSTA ZOFIA; WALLIS LAURA; EVANS TIMOTHY; DAVIES IEUAN; OTTER CARL; BATCHELOR RHYS
权利人:NZP UK LTD
摘要:The present invention relates to compounds which are intermediates in the synthesis of bile acid derivatives with pharmacological activity. The invention relates to compounds of general formula (I):wherein:, R1, R2, R3, R4, R5, R6 and Y are as defined herein.The compounds are intermediates in the synthesis of synthetic bile acids which are useful in the treatment of conditions such as liver disease. In addition, the invention relates to a method of synthesizing these intermediates and a method of preparing obeticholic acid and obeticholic acid analogues from the compounds of the invention.

专利号:US-10751419-B2
优先权日:2014-05-01
标题:Method for synthesis of reactive conjugate clusters
发明人：MIGAWA MICHAEL T; YU JINGHUA; WAN W BRAD; PATEL SAYTEN P; VASQUEZ GUILLERMO; KINBERGER GARTH A; PRAKASH THAZHA P; SETH PUNIT P; SWAYZE ERIC E
权利人:IONIS PHARMACEUTICALS INC
摘要:Provided herein are improved methods for the synthesis of reactive conjugate clusters and intermediates used in such methods. In particular, improvements are provided that enhance the synthesis of reactive conjugate clusters by reducing the number of synthetic steps required. The reactive conjugate clusters prepared using the improved methods don't include any transacylation impurities that are formed using existing methods. The improved methods also provide an increase in overall yield and a cost benefit over existing methods.

专利号:US-4354972-A
优先权日:1981-06-29
标 题 :Synthesis of steroids
发明人：KAISER EMIL T
权利人:KAISER EMIL T
摘要:This invention relates to the synthesis of steroids which are useful for their biological activity or which may be converted to steroids which have such activity. These syntheses include the steroid compounds and processes for their preparation. n An object of the invention is to provide syntheses which are applicable to materials which are readily available in good supply for converting such materials to steroids which are useful and desirable in the manufacture of pharmaceutical products. n More particularly, I have sought to discover processes and intermediate compounds useful in the synthesis of 24, 25-dihydroxycholesterol from hyodeoxycholic acid or lithocholic acid which are constituents of, and readily available from, animal bile.

专利号:US-12146136-B2
优先权日:2020-03-26
标题:Synthesis of modified oligonucleotides with increased stability
发明人：KHVOROVA ANASTASIA; ROUX LOÃ?C MAURICE RENÉ JEAN; YAMADA KEN
权利人:UNIV MASSACHUSETTS
摘要:This disclosure relates to the synthesis of novel modified oligonucleotides. The synthesis of novel phosphoramidites are also provided.

专利号:US-9828445-B1
优先权日:2016-12-13
标题:Synthesis of modified chitosan particles for oral insulin delivery
发明人：ATTA AYMAN M; AL-LOHEDAN HAMAD A; EZZAT ABDELRAHMAN O
权利人:UNIV KING SAUD
摘要:Synthesis of modified chitosan particles for oral insulin delivery includes amidation of chitosan with a fatty acid, a modified fatty acid, and/or an amino acid. The amidated chitosan can be grafted with N-isopropylacrylamide (NIPAm) and cross-linked to provide the modified chitosan particles.

专利号:WO-2025217610-A1
优先权日:2024-04-12
标题:Systems and methods for enzymatic oligonucleotide synthesis
发明人：ENTWISTLE DAVID; GAUNTLETT DEREK; MILLER MICHAEL; REEVES RYAN; WATTS DAVID
权利人:CODEXIS INC
摘要:The present invention provides for methods and systems for template-free synthesis of an oligonucleotide, and methods of using the systems as disclosed herein for template-free synthesis of an oligonucleotide.