CAS: 5197-62-6; 2-(2-(2-Chloroethoxy)Ethoxy)Ethanol

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CAS号75-21-8 环氧乙烷 | CAS号107-07-3 2-氯乙醇 | CAS号107-21-1 乙二醇 | CAS号7664-93-9 硫酸 | CAS号105891-50-7 2-[2-(2-chloroe... | CAS号108213-17-8 2-[2-(2-chloroe... | CAS号33941-15-0 1-氮杂-18-冠醚-6 | CAS号194425-46-2 Thiol-PEG6-alcohol | CAS号25743-12-8 NH-bis-PEG3 | CAS号26150-05-0 2-[2-(2-prop-2-... | CAS号2741-30-2 2-[2-[2-(二甲氨基)乙... | CAS号6338-55-2 2-[2-(2-氨基乙氧基)乙氧基]乙醇 | CAS号4437-01-8 七甘醇单甲醚 | CAS号134979-01-4 2-(2-(2-氨基乙氧基)乙...

三乙二醇置于氯化亚砜体系中,化学反应 6.0H,以84%的收率获得产物2-氯乙氧基-2-乙氧基二乙醇
参考文献:一种平滑受体配体
标题:一种平滑受体配体
摘要:本发明涉及生物技术领域,特别是涉及一种平滑受体配体.本发明提供一种平滑受体配体或其异构体前体药物,溶剂化物,药学上可接受的盐,所述平滑受体配体的结构式为:A--linker--b其中,A为胞外域配体结构,B为跨膜域配体结构;linker为线性的,对平滑受体无活性的亚基.本发明所提供的针对平滑受体的新型双头小分子配体,结合平滑受体的晶体结构数据,在胞外域配体和跨膜域配体的适当位点引入连接体,得到全新的双头配体小分子,增强了配体和受体之间的相互作用以及配体的生物活性.

专利信息

专利号:US-2004058888-A1
优先权日:2000-01-13
标题:Methods for synthesis of alpha-d-gal (1~>3) gal-containing oligosaccharides
发明人：BORNAGHI LAURENT; DEKANY GYULA; DRINNAN NICHOLAS BARRY; PAPAGEORGIOU JOHN; WEST MICHAEL LEO
摘要:This invention relates to reagents and methods for synthesis of biologically active di- and tri-saccharides comprising α-D-Gal(1→3)-D-Gal. In particular the invention provides novel reagents, intermediates and processes for the solution or solid phase synthesis of α-D-galactopyranosyl-(1→3)-D-galactose, and derivatives thereof. In one preferred embodiments the invention provides a protected monosaccharide building block of general formula (II): in which R 3 is methoxy or methyl; R 1 is H, benzoyl, pivaloyl, 4-chlorobenzoyl, acetyl, chloroacetyl, levulinoyl, 4-methylbenzoyl, benzyl, 3,4-methylenedioxybenzyl, 4-methoxybenzyl, 4-chlorobenzyl, 4-acetamidobenzyl, or 4-azidobenzyl; and R 2 is H, Fmoc, benzoyl, pivaloyl, 4-chlorobenzoyl, acetyl, chloroacetyl, levulinoyl, 4-methylbenzoyl, benzyl, 3,4-methylenedioxybenzyl, 4-methoxybenzyl, 4 -chlorobenzyl, 4-acetamidobenzyl, or 4-azidobenzyl.

专利号:US-8183355-B2
优先权日:2006-04-28
标题 :Method for the synthesis of oligonucleotide derivatives
发明人：MORVAN FRANCOIS; MEYER ALBERT; VASSEUR JEAN-JACQUES; VIDAL SEBASTIEN; CLOAREC JEAN-PIERRE; CHEVOLOT YANN; SOUTEYRAND ELIANE
权利人:MORVAN FRANCOIS; MEYER ALBERT; VASSEUR JEAN-JACQUES; VIDAL SEBASTIEN; CLOAREC JEAN-PIERRE; CHEVOLOT YANN; SOUTEYRAND ELIANE; CENTRE NAT RECH SCIENT
摘要:Method for the synthesis of nucleotide derivatives wherein molecules of interest are grafted on the oligonucleotide with the help of a “click chemistryâ€? reaction between an azide function on the molecule of interest and an alkyne function on the oligonucleotide, or between an alkyne function on the molecule of interest and an azide function on the oligonucleotide. n Intermediate molecules, notably alkyne functionalized oligonucleotides, grafted oligonucleotides, azide functionalized oligonucleotides, oligonucleotide micro arrays containing them and the use of those grafted oligonucleotides for biological investigation and for cell targeting.

专利号:US-2004171072-A1
优先权日:1998-03-31
标题:Solid support based on selenium useful in solid phase synthesis
发明人：RUHLAND THOMAS; ANDERSEN KIM; PEDERSEN HENRIK
权利人:LUNDBECK & CO AS H
摘要:This invention relates to novel solid support based on selenium and a method for the preparation thereof. The solid support is useful in solid phase synthesis of organic compounds including combinatorial libraries of compounds.

专利号:US-11718596-B2
优先权日:2014-03-19
标题 :Amyloid targeting agents and methods of using the same
发明人：YANG JERRY; THEODORAKIS EMMANUEL A; SARRAF STELLA
权利人:UNIV CALIFORNIA; AMYDIS INC
摘要:Provided herein is the design and synthesis of novel molecular rotor fluorophores useful for detection of amyloid or amyloid like proteins. The fluorophores are designed to exhibit enhanced fluorescence emission upon associating with amyloid or amyloid like proteins as compared to unbound compound. Also disclosed herein are methods for treating diseases associated with amyloid or amyloid like proteins.

专利号:US-7923584-B2
优先权日:2008-01-23
标题 :Synthesis of difunctional oxyethylene-based compounds
发明人：HOLMES BRIAN T; SNOW ARTHUR W
权利人:US NAVY
摘要:A method of reacting a toluenesulfonyl-terminated polyoxyethylene compound having the formula CH 3 —C 6 H 4 —SO 2 —(O—CH 2 —CH 2 ) n —O—R 1 with an ammonium salt having the formula NR 2 4 X to form a compound having the formula X—CH 2 —CH 2 —(O—CH 2 —CH 2 ) n-1 —R 3 . The value n is a positive integer. X is a halogen, cyanide, cyanate, thiocyanate, or azide. R 1 is a terminating group. Each R 2 is hydrogen or an alkyl group. —R 3 is —O—R 1 or —X.

专利号:RU-2118320-C1
优先权日:1993-03-15
标 题:Enantiomers of 1-[(4-chlorophenyl)phenylmethyl]-4-[(4-methylphenyl)sulfonyl]- -piperazine, method of their synthesis, method of synthesis of enantiomers of 1-[(4-chlorophenyl)phenylmethyl]-piperazine, enantiomers of 1-[(4-chlorophenyl)phenylmethyl]-piperazine, enantiomers of 1-[(4-chlorophenyl)phenylmethyl]-piperazine derivatives