CAS: 773-99-9; 2-(Naphthalen-1-yl)Ethanol

相似化合物

2122-70-5 2876-78-0 86-87-3

上下游产品

CAS号86-87-3 1-萘乙酸 | CAS号2876-78-0 1-萘乙酸甲酯 | CAS号703-55-9 1-萘基溴化镁 | CAS号826-74-4 1-乙烯基萘 | CAS号119744-43-3 1-(2-methanesul... | CAS号2122-70-5 2-(1-萘基)乙酸乙酯 | CAS号273214-51-0 2-(benzylthio)-... | CAS号2876-73-5 Hexyl 1-naphthy... | CAS号51537-87-2 1-萘乙酸4-硝基苯酯 | CAS号68480-12-6 1,2,3,4-Tetrahy... | CAS号3243-42-3 3-(1-萘基)丙酸 | CAS号41332-02-9 1-(2-氯乙基)萘 | CAS号2086-62-6 2-(2-溴乙基)萘 | CAS号86-55-5 1-萘甲酸 | CAS号2876-53-1 1-Hexylnaphthalene | CAS号3099-62-5 1-(1-Naphthyl)-... | CAS号86-87-3 1-萘乙酸 | CAS号826-74-4 1-乙烯基萘 | CAS号72642-30-9 (1-Naphthyl)eth... | CAS号15727-65-8 1-乙炔基萘

1-萘乙酸置于lithium Aluminium Tetrahydride,水,氯化铵体系中,用 四氢呋喃 作为反应溶剂,化学反应 2.0H,反应生成 1-萘乙醇
参考文献:Fecl 3促进的炔基和萘乙醛与炔烃环化反应的区域选择性合成取代的萘和菲
标题:Fecl 3促进的炔基和萘乙醛与炔烃环化反应的区域选择性合成取代的萘和菲
摘要:已经建立了fecl 3促进的芳基乙醛与炔烃的环化反应,这为温和条件下单,双和多取代的萘的区域选择性合成提供了一种新的通用直接方法.有趣的是,本催化体系不仅在内部炔烃和末端炔烃之间进行区分,而且对甲硅烷基炔烃底物显示出前所未有的完全的me 3 Sioh消除选择性.此外,还首次以高收率和极好的区域选择性实现了通过萘乙乙醛与内部炔烃的反应合成一系列取代的菲.
DOI:10.1016/j.Tet.2012.07.007

专利信息

专利号:US-2004014168-A1
优先权日:1998-06-11
标题:Reagents and methods for library synthesis and screening
发明人：SCHREIBER STUART L; BLACKWELL HELEN E; PEREZ FERNANDEZ LUCY; TALLARICO JOHN A
权利人:HUGHES HOWARD MED INST
摘要:The invention provides novel solid supports for the synthesis of compound libraries. The solid supports have the physical capacity to deliver at least 50 nmol of compound and are functionalized with a silicon-containing linker. In one embodiment of the invention the solid support comprises a bead having a diameter of between approximately 400 and 600 μm functionalized with a silicon-containing linker. According to certain embodiments of the invention the bead is a polystyrene bead. According to certain embodiments of the invention the linker is a diisopropylalkyl-substituted silyl ether. The invention further provides grafted polymeric supports such as lanterns functionalized with a silicon-containing linker. n The invention provides methods for screening in which compounds are synthesized on solid supports in a quantity so that a single solid support such as a bead provides a stock solution sufficient to perform hundreds or thousands of biological or chemical assays. The methods include decoding the sequence of chemical reactions used to synthesize the compound by identifying tags incorporated into the compound during synthesis.

专利号:US-6906046-B2
优先权日:2000-12-22
标题 :Pharmaceutical uses and synthesis of benzobicyclooctanes
发明人：JACKSON RANDY W; DARWISH IHAB; BAUGHMAN TED A; HOWBERT J JEFFRY
权利人:CELLTECH R & D INC
摘要:Benzobicyclooctane compounds, their use in inhibiting cellular events involving TNF-α and IL-8, and in the treatment of inflammation events in general; a combinatorial library of diverse bicyclooctanes and process for their synthesis as a library and as individual compounds.

专利号:US-6147159-A
优先权日:1998-09-30
标 题 :Compositions for organic synthesis on solid phase and methods of using the same
发明人：HU YONGHAN; LABADIE JEFFREY W; PORCO JR JOHN ANTHONY; TROST BARRY MARTIN
权利人:ARGONAUT TECHNOLOGIES
摘要:A modified solid support for use in solid phase synthesis which comprises: a solid support having a linker group extending therefrom having the general formula: wherein R1 and R2 are each independently selected from the group consisting of alkyl, cycloalkyl, aryl, alkoxy, aryloxy, fluorine, chlorine, iodine and bromine.

专利号:US-2004053999-A1
优先权日:1997-09-17
标题 :Novel compounds and methods for synthesis and therapy
发明人：BISCHOFBERGER NORBERT W; DAHL TERRENCE C; HITCHCOCK MICHAEL J M; KIM CHOUNG U; LEW WILLARD; LIU HONGTAO; MILLS ROGER G; WILLIAMS MATTHEW A
摘要:Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.

专利号:US-7186709-B2
优先权日:2002-08-27
标 题:Dihydropyrancarboxamides and uses thereof
发明人：SCHREIBER STUART L; STAVENGER ROBERT A; MITCHISON TIMOTHY J; MALIGA ZOLTAN
权利人:HARVARD COLLEGE
摘要:The present invention provides novel dihydropyrancarboxamide compounds of formula (I): n nand collections of these compounds, and provides methods for the synthesis of these compounds; wherein R 1 –R 6 are as defined herein. Additionally, the present invention provides pharmaceutical compositions and methods for treating disorders such as proliferative diseases, and cancer, to name a few.

专利号:US-6225341-B1
优先权日:1995-02-27
标 题:Compounds and methods for synthesis and therapy
发明人：BISCHOFBERGER NORBERT W; KIM CHOUNG U; LEW WILLARD; LIU HONGTAO; WILLIAMS MATTHEW A
权利人:GILEAD SCIENCES INC
摘要:Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.