CAS: 88211-50-1; But-3-Yn-1-Amine Hydrochloride

该化合物是盐酸盐,但有3-y-yn-1-aminine, 其特点是终端的烷基化合物组和主要矿物质功能.该化合物在有机合成中很有价值, 特别是在点击化学应用中. 其碳基化合物组可产生高效的铜催化氮-烷-烷循环添加反应(CuAAC) . 盐化形式增强了稳定性和溶解性, 便利了处理和储存. 它的双功能再活动使它成为制药,农用化学和材料科学的多功能建筑块. 化合物的纯度和定义明确的结构确保了组合反应和衍生过程的一贯性. 它对于研究和工业应用来说,为构建复杂的分子结构提供了一个可靠的中间体.

英文名称But-3-Yn-1-Amine Hydrochloride
中文名称3-丁炔-1-胺盐酸盐
IUPAC名称but-3-yn-1-amine hydrochloride
其它别名丁-3-炔-1-基氯化铵
CAS编号88211-50-1
MFCD编号:MFCD06658391
EINECS号:817-418-1
分子式:C4H8ClN
分子量:105.57
产品CID: 1891524
产品分类有机原料→分子砌块→脂肪链类化合物

相似结构搜索
InChIKey: PQEPCBUBKRUREA-UHFFFAOYSA-N
InChI=1S/C4H7N.ClH/c1-2-3-4-5;/h1H,3-5H2;1H…
计算化学: 氢键受体数1.0氢键供体数1.0可旋转键数1.0

相似化合物

149990-27-2 149965-78-6 161040-05-7

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别急性毒性类别4(经口)
特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2
严重眼刺激类别2A
警示词Warning(警告)
危险描述H302 |吞咽有害.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
危险品标志Xi

欧盟法规

C&L通报

合成工艺路线路线简述

合成目标产物 3-Butyn-1-Amine Hydrochloride 主要起始原料 Tert-Butyl But-3-Yn-1-Ylcarbamate
10451-00-0 = 88211-50-1
反应条件:1.1 Reagents: Triphenylphosphine Solvents: Diethyl Ether; 2 H,0 °C1.2 Solvents: Water; 20 H,Rt
标题:Binding Of Calix[4]Pyrroles To Pyridine N-Oxides Probed With Surface Plasmon Resonance
作者:Adriaenssens,Louis; Et Al
参考文献:Chemical Science 日期:2014 卷标:5(11) 页码:4210-4215]

72486-09-0 = 88211-50-1
反应条件:1.1 Reagents: Sodium Azide Solvents: Dimethylformamide; 1 Min,Rt; Rt -> 70 °C; 4 H,70 °C1.2 Reagents: Triphenylphosphine Solvents: Diethyl Ether; 2 H,0 °C1.3 Solvents: Water; 20 H,Rt
标题:Binding Of Calix[4]Pyrroles To Pyridine N-Oxides Probed With Surface Plasmon Resonance
作者:Adriaenssens,Louis; Et Al
参考文献:Chemical Science 日期:2014 卷标:5(11) 页码:4210-4215]

88211-44-3 = 88211-50-1
反应条件:1.1 Solvents: Diethyl Ether1.2 Reagents: Hydrochloric Acid Solvents: Water
标题:Sodium Hexamethyldisilazide
作者:Watson,Brett T.; Et Al
参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2005 卷标:1 页码:1-10]

14396-90-8 = 88211-50-1
反应条件:1.1 Reagents: Hydrazine Hydrate (1:1) Solvents: Ethanol; 3 D,Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; 15 H,Rt
标题:Palladium-Catalyzed Cyclization Of N-Alkynyl Aminomalonates
作者:Hess,Wilfried; Et Al
参考文献:Chemistry - A European Journal 日期:2010 卷标:16(41) 页码:12303-12306]

1070-89-9 = 88211-50-1
反应条件:1.1 Solvents: Tetrahydrofuran2.1 Solvents: Diethyl Ether2.2 Reagents: Hydrochloric Acid Solvents: Water
标题:Sodium Hexamethyldisilazide
作者:Watson,Brett T.; Et Al
参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2005 卷标:1 页码:1-10]

927-74-2 = 88211-50-1
反应条件:1.1 Reagents: Triphenylphosphine,Diisopropyl Azodicarboxylate Solvents: Toluene; 10 Min,0 °C; 1 H,Rt1.2 Reagents: Methanol; 30 Min,Rt2.1 Reagents: Hydrazine Hydrate (1:1) Solvents: Ethanol; 2 H,Reflux
标题:Design,Synthesis And Structure-Activity Relationships Of Novel 15-Membered Macrolides: Quinolone/quinoline-Containing Side-Chains Tethered To The C-6 Position Of Azithromycin Acylides
作者:Fan,Bing-Zhi; Et Al
参考文献:European Journal Of Medicinal Chemistry 日期:2020 卷标:193]

10451-00-0 = 88211-50-1
反应条件:1.1 Reagents: Hydrazine Hydrate (1:1) Catalysts: Ruthenium (Polystyrene Supported Nanoparticles) Solvents: Ethanol; Rt; 12 H,Rt1.2 Reagents: Hydrochloric Acid Solvents: Methanol
标题:Chemo- And Site-Selective Alkyl And Aryl Azide Reductions With Heterogeneous Nanoparticle Catalysts
作者:Udumula,Venkatareddy; Et Al
参考文献:Acs Catalysis 日期:2016 卷标:6(7) 页码:4423-4427]

10451-00-0 = 88211-50-1
反应条件:1.1 Reagents: 1,2-Bis(Diphenylphosphino)Ethane Solvents: Tetrahydrofuran,Water; 16 H,Rt1.2 Reagents: Hydrochloric Acid Solvents: Water
标题:Synthesis And Biological Evaluation Of A Triazole-Based Library Of Pyrido[2,3-D]Pyrimidines As Fgfr3 Tyrosine Kinase Inhibitors
作者:Le Corre,Laurent; Et Al
参考文献:Organic & Biomolecular Chemistry 日期:2010 卷标:8(9) 页码:2164-2173]

14044-63-4 = 88211-50-1
反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Water
标题:A Novel Bis-Triazole Scaffold Accessed Via Two Tandem [3 + 2] Cycloaddition Events Including An Uncatalyzed,Room Temperature Azide-Alkyne Click Reaction
作者:Malkova,Ksenia; Et Al
参考文献:Beilstein Journal Of Organic Chemistry 日期:2022 卷标:18 页码:1636-1641]

14396-90-8 = 88211-50-1
反应条件:1.1 Reagents: Hydrazine Hydrate (1:1) Solvents: Toluene; 1 H,Reflux; Reflux -> 0 °C1.2 Reagents: Hydrochloric Acid Solvents: Water
标题:Chromium(0)-Catalyzed Tandem Cyclization Of α,β-Unsaturated Thioimidates Containing An Enyne Moiety
作者:Karibe,Yusuke; Et Al
参考文献:Angewandte Chemie 日期:2012 卷标:51(25) 页码:6214-6218]

14396-90-8 = 88211-50-1
反应条件:1.1 Reagents: Hydrazine Hydrate (1:1) Solvents: Ethanol; 2 H,Reflux
标题:Design,Synthesis And Structure-Activity Relationships Of Novel 15-Membered Macrolides: Quinolone/quinoline-Containing Side-Chains Tethered To The C-6 Position Of Azithromycin Acylides
作者:Fan,Bing-Zhi; Et Al
参考文献:European Journal Of Medicinal Chemistry 日期:2020 卷标:193]

23418-85-1 = 88211-50-1
反应条件:1.1 Reagents: Sodium Azide Solvents: Dimethylformamide; 40 H,Rt1.2 Reagents: Triphenylphosphine Solvents: Diethyl Ether; 40 H,Rt1.3 Reagents: Hydrochloric Acid Solvents: Water; 2 H,Rt
标题:Palladium-Catalyzed Cyclization Of N-Alkynyl Aminomalonates
作者:Hess,Wilfried; Et Al
参考文献:Chemistry - A European Journal 日期:2010 卷标:16(41) 页码:12303-12306]

88211-47-6 = 88211-50-1
反应条件:1.1 Reagents: Hydrochloric Acid
标题:N,N-Bis(Trimethylsilyl)Aminomethylation Of Grignard Compounds - A Broad-Scope Amine Synthesis
作者:Bestmann,Hans Juergen; Et Al
参考文献:Angewandte Chemie 日期:1984 卷标:96(1)]

88211-44-3 + 106-96-7 = 88211-50-1
反应条件:1.1 -2.1 Reagents: Hydrochloric Acid
标题:N,N-Bis(Trimethylsilyl)Aminomethylation Of Grignard Compounds - A Broad-Scope Amine Synthesis
作者:Bestmann,Hans Juergen; Et Al
参考文献:Angewandte Chemie 日期:1984 卷标:96(1)]

1070-89-9 = 88211-50-1
反应条件:1.1 -2.1 -3.1 Reagents: Hydrochloric Acid
标题:N,N-Bis(Trimethylsilyl)Aminomethylation Of Grignard Compounds - A Broad-Scope Amine Synthesis
作者:Bestmann,Hans Juergen; Et Al
参考文献:Angewandte Chemie 日期:1984 卷标:96(1)]

72486-09-0 + 1074-82-4 = 88211-50-1
反应条件:1.1 Catalysts: Sodium Iodide Solvents: Dimethylformamide; 10 Min,Rt; Rt -> 100 °C; 4 H,100 °C; 100 °C -> Rt2.1 Reagents: Hydrazine Hydrate (1:1) Solvents: Ethanol; 3 D,Rt2.2 Reagents: Hydrochloric Acid Solvents: Water; 15 H,Rt
标题:Palladium-Catalyzed Cyclization Of N-Alkynyl Aminomalonates
作者:Hess,Wilfried; Et Al
参考文献:Chemistry - A European Journal 日期:2010 卷标:16(41) 页码:12303-12306]

927-74-2 = 88211-50-1
反应条件:1.1 Reagents: Triethylamine Solvents: Diethyl Ether; 0 °C; 0 °C -> Rt; 4 H,Rt2.1 Reagents: Sodium Azide Solvents: Dimethylformamide; 1 Min,Rt; Rt -> 70 °C; 4 H,70 °C2.2 Reagents: Triphenylphosphine Solvents: Diethyl Ether; 2 H,0 °C2.3 Solvents: Water; 20 H,Rt
标题:Binding Of Calix[4]Pyrroles To Pyridine N-Oxides Probed With Surface Plasmon Resonance
作者:Adriaenssens,Louis; Et Al
参考文献:Chemical Science 日期:2014 卷标:5(11) 页码:4210-4215]

927-74-2 = 88211-50-1
反应条件:1.1 Reagents: Triphenylphosphine,Diethyl Azodicarboxylate Solvents: Tetrahydrofuran; Overnight,Rt2.1 Reagents: Hydrazine Hydrate (1:1) Solvents: Toluene; 6 H,Reflux3.1 Reagents: Hydrochloric Acid Solvents: Water
标题:A Novel Bis-Triazole Scaffold Accessed Via Two Tandem [3 + 2] Cycloaddition Events Including An Uncatalyzed,Room Temperature Azide-Alkyne Click Reaction
作者:Malkova,Ksenia; Et Al
参考文献:Beilstein Journal Of Organic Chemistry 日期:2022 卷标:18 页码:1636-1641

1-氨基-3-丁炔置于盐酸体系中,用水作为反应溶剂,化学反应生成 3-丁炔-1-胺盐酸盐
参考文献:Synthesis And Biological Evaluation Of A Triazole-Based Library Of Pyrido[2,3-D]Pyrimidines As Fgfr3 Tyrosine Kinase Inhibitors
标题:Synthesis And Biological Evaluation Of A Triazole-Based Library Of Pyrido[2,3-D]Pyrimidines As Fgfr3 Tyrosine Kinase Inhibitors
摘要:设计了一系列吡啶并[2,3-D]嘧啶类化合物作为fgfr3酪氨酸激酶的抑制剂,这些化合物可能与atp结合位点的一个未开发区域发生相互作用.该化合物库通过高效的点击化学步骤构建,便于合成含有多种取代基的三唑类化合物.在合成的27个类似物中,超过一半的化合物在2微摩尔浓度下对体外fgfr3激酶活性表现出55-89%的抑制作用,其中一个化合物(19G)能够抑制转染hek细胞中突变型fgfr3-K650M的自磷酸化.
DOI:10.1039/b923882D

海关参考信息

2901292000-乙炔
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专利信息

专利号:US-7259277-B2
优先权日:2003-07-25
标题 :Advanced route for the synthesis of cPLA2 inhibitors
发明人：WU YANZHONG; RAVEENDRATH PANOLIL
权利人:WYETH CORP
摘要:A process for making a compound of formula (I) n nin which process the compound HCâ‰¡Câ€”(CH 2 ) n â€”NH 2 is reacted with the compound R 1 â€”SO 2 Cl to produce an intermediate compound, which intermediate compound is then reacted with the compound of formulan n nto produce the compound of formula (I), and compounds produced by the process of this invention. The terms R 1 , R 2 , R 3 , R 4 and n have the definitions set forth in the specification.

专利号:US-8071718-B2
优先权日:2004-12-22
标题:Selective radiolabeling of biomolecules
发明人：PADILLA DE JESUS OMAYRA LIZ; KOVACS ERNEST WILLIAM; GLASER MATTHIAS EBERHARD; ARSTAD ERIK; SYUD FAISAL AHMED
权利人:PADILLA DE JESUS OMAYRA LIZ; KOVACS ERNEST WILLIAM; GLASER MATTHIAS EBERHARD; ARSTAD ERIK; SYUD FAISAL AHMED; GEN ELECTRIC
摘要:Provided herein are methods for introducing fluorine atom onto a biomolecule comprising: (i) providing a linker comprising a thiol-reactive terminus and an azido/alkyne-reactive terminus; (ii) reacting the thiol-reactive terminus of the linker with a biomolecule comprising at least one thiol group or a reactive derivative thereof; and (iii) subsequently reacting the azido/alkyne-reactive terminus of the linker with a fluorine-substituted azide or alkyne respectively. Also provided are compositions and method of synthesis of bifunctional linkers and bioconjugates as well as radio-diagnostic agents comprising fluorine-labeled biomolecules.

专利号:US-2005020858-A1
优先权日:2003-07-25
标题:Advanced route for the synthesis of cPLA2 inhibitors

专利号:US-2005159613-A1
优先权日:2003-07-25
标题:Advanced route for the synthesis of cPLA2 inhibitors

专利号:US-6891065-B2
优先权日:2003-07-25
标题:Advanced route for the synthesis of cPLA2 inhibitors