CAS: 104632-26-0; (S)-N6-Propyl-4,5,6,7-Tetrahydrobenzo[d]Thiazole-2,6-Diamine

相似化合物

104632-25-9 104617-86-9 104617-85-8

上下游产品

CAS号1001648-71-0 (6S,7S)-2-氨基-4,... | CAS号123-38-6 丙醛 | CAS号106092-09-5 (S)-2,6-二氨基-4,5... | CAS号106006-84-2 s-2-氨基-6-丙酰氨基-4... | CAS号104632-25-9 盐酸普拉克索 | CAS号106-94-5 溴代丙烷 | CAS号147-71-7 D-酒石酸 | CAS号104617-86-9 (±)-Pramipexole | CAS号106006-83-1 2,6-二氨基-4,5,6,7... | CAS号1373869-93-2 ka-3-7-1 | CAS号120-80-9 邻苯二酚 | CAS号104632-25-9 盐酸普拉克索

Pramipexole Dihydrochloride置于氢氧化钾体系中,用 水 用作溶剂,化学反应 2.0H,以86%的收率获得普拉克索
参考文献:Process For The Reduction Of (S)-2-Amino-6-Propionamido-4,5,6,7-Tetrahydrobenzo-Thiazole
标题:Process For The Reduction Of (S)-2-Amino-6-Propionamido-4,5,6,7-Tetrahydrobenzo-Thiazole
摘要:本公开了一种还原(S)-2-氨基-6-丙酰胺基-4,5,6,7-四氢苯并噻唑醇的方法,包括在适当的有机溶剂存在下,将(S)-2-氨基-6-丙酰胺基-4,5,6,7-四氢苯并噻唑醇与硼烷试剂反应,得到(S)-2-氨基-6-丙基氨基-4,5,6,7-四氢苯并噻唑醇碱,可转化为其酸盐.本文提供的方法可以轻松,方便,廉价地进行扩大规模.

专利信息

专利号:US-9353057-B2
优先权日:2003-12-30
标 题:Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
发明人：GALLOP MARK A; DAI XUEDONG; SCHEUERMAN RANDALL A; RAILLARD STEPHEN P; MANTHATI SURESH K; YAO FENMEI; PHAN THU; LUDWIKOW MARIA; PENG GE; BHAT SEEMA
权利人:XENOPORT INC
摘要:Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.

专利号:US-9512096-B2
优先权日:2011-12-22
标题 :Synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds
发明人：CHEN WEIRONG; HUMORA MICHAEL; KWOK DAW-LONG ALBERT; KIESMAN WILLIAM F; IRDAM ERWIN AYANDRA
权利人:KNOPP BIOSCIENCES LLC; KNOPP BIOSCIENCES LLP
摘要:The present invention is related to an improved process for the preparation of amino-substituted 4,5,6,7-tetrahydrobenzothiazole compounds of formula I, such as the compound 2-amino-4,5,6,7-tetrahydro-6-(n-propylamino)benzothiazole. The invention further relates to an improved synthesis of (R)-2-amino-4,5,6,7-tetrahydro-6-(n-propylamino)benzothiazole. The invention also relates to the methods and intermediates associated with the synthetic process.

专利号:US-9315483-B2
优先权日:2007-09-13
标题 :Synthesis of deuterated catechols and benzo[D][1,3]dioxoles and derivatives thereof
发明人：JONES ANDREW D; ZELLE ROBERT E; SILVERMAN I ROBERT
权利人:CONCERT PHARMACEUTICALS INC
摘要:The present invention provides a convenient and efficient process for the synthesis of d 2 -benzo[d][1,3]dioxoles.

专利号:US-2025206743-A1
优先权日:2022-03-25
标 题:Tyk2 inhibitor synthesis and intermediates thereof
发明人：MASSE CRAIG E; PHADKE AVINASH S; LAWSON JON P; LEVY STUART; YANG XIAOWEI; WU GUISHENG; FAN SHUFENG
权利人:TAKEDA PHARMACEUTICALS CO
摘要:Described herein are methods of synthesis of a tyrosine-protein kinase 2 (TYK2) inhibitor and to intermediate compounds of the synthesis and methods of making the intermediates. Also provided are pharmaceutically acceptable compositions including compounds prepared by the synthetic method and methods of treating disorders using the same.

专利号:US-2024082118-A1
优先权日:2021-05-19
标 题:Topical compositions and methods of preparing the same
发明人：ABRAMOVICH SAGI; AVIDOR GAL; LANDA BENZION
权利人:LANDA LABS 2012 LTD
摘要:There is disclosed a composition comprising a water-insoluble thermoplastic compound capable of stimulating collagen synthesis (CSSC), the CSSC having a molecular weight of more than 0.6 kDa and being dispersed in a polar carrier as nano-elements having an average diameter of 200 nm or less and a viscosity of 107 mPa·s or less. The nano-elements of CSSC can be capable of stimulating the synthesis of skin proteins and/or enabling the delivery of active agents upon their application to a surface to be treated therewith. Methods for preparing the compositions and uses thereof are also provided.

专利号:US-11958866-B1
优先权日:2023-04-07
标题:Synthesis of thiazole derivatives
发明人：NOOR AWAL; KHAN EZZAT; KHAN UMAR ALI
权利人:UNIV KING FAISAL
摘要:A synthetic protocol to use a thiourea or urea compound and auric chloride as starting materials to obtain thiazole and benzothiazole derivatives. The synthesis can be conducted at room temperature and the final compound can result from cyclization of the thiourea or urea compound in the presence of an Au salt from the auric chloride.